April 2023 PMID 36813729

Association Between Regular Laxative Use and Incident Dementia in UK Biobank Participants.

Zhirong Yang, Chang Wei, Xiaojuan Li, Jinqiu Yuan, Xuefeng Gao, Bingyu Li, Ziyi Zhao, Sengwee Toh, Xin Yu, Carol Brayne, Zuyao Yang, Feng Sha, Jinling Tang

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Mentions

356

Peak: 15 in Mar 2023

across 6 sources since Feb 2023

Extended reach

525,887

potential audience

Total likes

108

Video views

3,932

Mentions per month

Feb 2023 – May 2025

Where it's discussed

News304 articles
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Blogs8 articles
Facebook5 posts
Reddit3 posts
YouTube2 videos

AI synopsis

What people are saying

Several discussions highlight the potential link between regular laxative use and dementia risk, with phrases like 'gut-brain connection' and 'correlation is fascinating,' illustrating interest beyond mere acknowledgment. The tone combines cautious curiosity with critical considerations of causality, reflecting moderate engagement and recognition of the study’s possible implications in understanding brain health and gut microbiome interactions.

AgreementModerate agreement

Most discussions acknowledge the study, with some expressing cautious curiosity, indicating a mild agreement or recognition of the research's significance.

InterestHigh interest

Posts show high interest through references to specific details like the gut-brain connection and mentions of the large sample size, suggesting curiosity about the findings and implications.

EngagementModerate engagement

Some discussions evaluate the methodology or raise concerns such as causation versus correlation, pointing to moderate to deep engagement with the content.

ImpactModerate impact

There is a perception that the study could influence future research and medical practices, but the overall tone suggests recognition of its preliminary or associative nature rather than definitive impact.

Abstract in brief

Regular use of laxatives, especially osmotic types, was linked to a higher risk of developing all-cause dementia and vascular dementia (VD) in UK Biobank participants, but not significantly associated with Alzheimer's disease.
The study found that the risk increased with the number of different laxative types used regularly, suggesting a dose-response relationship.
Overall, the findings imply that consistent laxative use might be a factor related to dementia risk, highlighting the need for further research into how gut health and medications impact brain health.

Read the full abstract

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ねこやん

@nekoyann123 · X

RT @neurology2025: 講演会用メモ。下剤を常用している人は認知症リスクが高いという報告。下剤の種類が増えるほどリスクが高かった。https://t.co/HpOxpFhoBv

Oct 6, 2024 · 1 share · 222 followers View post →

集患に苦労する内科医

@neurology2025 · X

講演会用メモ。下剤を常用している人は認知症リスクが高いという報告。下剤の種類が増えるほどリスクが高かった。https://t.co/HpOxpFhoBv

Sep 6, 2024 · 9 likes · 1 share · 1,013 followers View post →

Crazy Magpie

@magpie_crazy · X

If you knew that MiraLAX is PROPOLYENE GLYCOL - aka antifreeze - PLS REFUSE TO TAKE IT https://t.co/e5fEG7OXog

Apr 16, 2024 · 287 followers View post →

the paper link

@the_paper_link · X

Trend up+11: Yang Z, ..., Tang J (Neurology) __Association Between Regular Laxative Use and Incident Dementia in UK Biobank Participants__ https://t.co/ACLIcbWRkm

Apr 20, 2023 · 138 followers View post →

Shiva Gopal Vasishta

@ShivaVasishta · X

Association Between Regular Laxative Use and Incident Dementia in UK Biobank Participants https://t.co/skIm52LS7z #neurology #doctors #medtwitter #medical #medicinenews #healthcare

Apr 17, 2023 · 336 followers View post →

the paper link

@the_paper_link · X

Trend up+9: Yang Z, ..., Tang J (Neurology) __Association Between Regular Laxative Use and Incident Dementia in UK Biobank Participants__ https://t.co/ACLIcbWRkm

Apr 15, 2023 · 138 followers View post →

the paper link

@the_paper_link · X

Trend up+5: Yang Z, ..., Tang J (Neurology) __Association Between Regular Laxative Use and Incident Dementia in UK Biobank Participants__ https://t.co/ACLIcbWRkm

Apr 12, 2023 · 138 followers View post →

the paper link

@the_paper_link · X

Trend up+13: Yang Z, ..., Tang J (Neurology) __Association Between Regular Laxative Use and Incident Dementia in UK Biobank Participants__ https://t.co/ACLIcbWRkm

Mar 31, 2023 · 138 followers View post →

山本陵平

@yamamotoryohei_ · X

RT @syuichiao89: Association Between Regular Laxative Use and Incident Dementia in UK Biobank Participants https://t.co/XOw6tyKFEm

Mar 30, 2023 · 1 share · 219 followers View post →

青島周一@【書籍】「生成AIと学ぶ医学論文の読み方・考え方」発売中！

@syuichiao89 · X

Association Between Regular Laxative Use and Incident Dementia in UK Biobank Participants https://t.co/XOw6tyKFEm

Mar 29, 2023 · 2 likes · 1 share · 8,604 followers View post →

たけちゃん

@nitrotake · X

全文よめなぁぁい！！下剤の使用と認知症の関係性交絡要因気になりますね…(´・ω・`) https://t.co/rKAaorePM5

Mar 23, 2023 · 3 likes · 1,441 followers View post →

Get the Brain

@get_brain · X

RT @ecalixto: Referencia: Yan et al., Neurology 2023 doi: 10.1212/WNL.0000000000207081.

Mar 22, 2023 · 3 shares · 26 followers View post →

ttyosida

@ApoTatsu · X

定期的な下剤使用と認知症発生との関連 Association Between Regular Laxative Use and Incident Dementia in UK Biobank Participants https://t.co/QMkxse8cKQ

Mar 22, 2023 · 66 followers View post →

Miguel Angel Ruiz

@Mars_777 · X

RT @ecalixto: Referencia: Yan et al., Neurology 2023 doi: 10.1212/WNL.0000000000207081.

Mar 21, 2023 · 3 shares · 2,614 followers View post →

Miguel Angel Ruiz

@Mars_777 · X

RT @ecalixto: Referencia: Yan et al., Neurology 2023 doi: 10.1212/WNL.0000000000207081.

Mar 21, 2023 · 2 shares · 2,614 followers View post →

PsicoterapiayAcupunt

@psiyacu · X

RT @ecalixto: Referencia: Yan et al., Neurology 2023 doi: 10.1212/WNL.0000000000207081.

Mar 19, 2023 · 3 shares · 22 followers View post →

carmen

@Cami45pp · X

RT @ecalixto: Referencia: Yan et al., Neurology 2023 doi: 10.1212/WNL.0000000000207081.

Mar 18, 2023 · 2 shares · 539 followers View post →

Eduardo Calixto

@ecalixto · X

Referencia: Yan et al., Neurology 2023 doi: 10.1212/WNL.0000000000207081.

Mar 18, 2023 · 10 likes · 3 shares · 186,686 followers View post →

Eduardo Calixto

@ecalixto · X

Referencia: Yan et al., Neurology 2023 doi: 10.1212/WNL.0000000000207081.

Mar 18, 2023 · 13 likes · 2 shares · 186,686 followers View post →

Cipatli Ayuzo

@cipatlimd · X

▶️A pesar de ser una gran cantidad de información para fines de investigación, no es representativa de otros países. Association Between Regular Laxative Use and Incident Dementia in UK Biobank. American Academy of Neurology 2023, https://t.co/KGPkg0vbps>

Mar 3, 2023 · 2 likes · 1,531 followers View post →

DrRPalmquist

@DrPalmquist · X

Association Between Regular Laxative Use and Incident Dementia in UK Biobank Participants https://t.co/HLTdfE4Km2

Mar 1, 2023 · 3,166 followers View post →

katie wright

@katiewr31413491 · X

RT @PaulWhiteleyPhD: Association Between Regular Laxative Use and Incident Dementia in UK Biobank Participants https://t.co/u4xbqPM5Hx N=+5…

Mar 1, 2023 · 1 share · 13,023 followers View post →

Wei Lee

@WeiLeePC · X

Association Between Regular Laxative Use and Incident Dementia in UK Biobank Participants https://t.co/vZb8prRKmM

Feb 27, 2023 · 32 followers View post →

Paul Whiteley

@PaulWhiteleyPhD · X

@kemminnick PubMed version of abstract is here: https://t.co/gYUSN9AkHO Depletion of gut bacteria would probably also follow chronic laxative use...

Feb 27, 2023 · 4,955 followers View post →

Paul Whiteley

@PaulWhiteleyPhD · X

Association Between Regular Laxative Use and Incident Dementia in UK Biobank Participants https://t.co/u4xbqPM5Hx N=+500K & ~10 year follow-up. Causation not proven but gut-brain *correlation* is mighty interesting. Important too for some vulnerable groups with bowel conditions?

Feb 27, 2023 · 1 like · 1 share · 4,955 followers View post →

いっちー@バーチャル精神科医

@ichiipsy · X

Association Between Regular Laxative Use and Incident Dementia in UK Biobank Participants https://t.co/S7gRr1uFYd

Feb 25, 2023 · 3 likes · 79,168 followers View post →

سرباز دل

@Kn4veOfHe4rts · X

Feb 25, 2023 · 8 likes · 50 followers View post →

David Ramos

@Davidr1049 · X

Association Between Regular Laxative Use and Incident Dementia in UK Biobank Participants https://t.co/popFsIsX0F

Feb 23, 2023 · 62 followers View post →

Global Health Observ

@GlobalPHObserv · X

Association Between Regular Laxative Use and Incident Dementia in UK Biobank Participants | Neurology https://t.co/1Z2Wo3bbzP

Feb 23, 2023 · 6,554 followers View post →

Indranil Sinha

@Sinhaind · X

Association Between Regular Laxative Use and Incident Dementia in UK Biobank Participants https://t.co/Uo1D1zGgV3

Feb 23, 2023 · 271 followers View post →

小嶋慎二＠community pharmacist

@kojima_aponet · X

【Neurology Feb 22,2023】 Association Between Regular Laxative Use and Incident Dementia in UK Biobank Participants https://t.co/8EnguYFnrq

Feb 23, 2023 · 8,123 followers View post →

サイエンスあれこれ

@sarekore · X

発症するリスクが、下剤を使用しない人よりも50%以上高くなる可能性があることがわかりました。また、1 種類の下剤を使用している人ではリスクが 28% 増加し、2 種類以上の下剤を使用している人ではリスクが 90% 増加しました。1種類のみを使用している人の中で、浸透圧性下剤https://t.co/2gxpjIWqDM

Feb 23, 2023 · 2 likes · 923 followers View post →

RADIOLOGY_papers

@BtzPapers · X

Association Between Regular Laxative Use and Incident Dementia in UK Biobank Participants https://t.co/WCA5w9rR5D

Feb 23, 2023 · 12 followers View post →

Microbiome Articles

@microbe_article · X

Association between regular laxative use and incident dementia in uk biobank participants. - Yang Z et al. - https://t.co/BfIhvDF2Fe #microbiome

Feb 23, 2023 · 7,156 followers View post →

Association Between Regular Laxative Use and Incident Dementia in UK Biobank Participants.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Medications Linked to Increased Dementia Risk: Key Findings

Proton Pump Inhibitors and Increased Dementia Risk: A Study Review