Nat Commun February 2023 PMID 36813769

The Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments.

Wenyan Wan, Hui Dong, De-Hua Lai, Jiong Yang, Kai He, Xiaoyan Tang, Qun Liu, Geoff Hide, Xing-Quan Zhu, L David Sibley, Zhao-Rong Lun, Shaojun Long

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Mentions

Peak: 1 in Feb 2023

across 3 sources since Feb 2023

Extended reach

351

potential audience

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Mentions per month

Feb 2023 – Jun 2023

Where it's discussed

News2 articles
X / Twitter1 posts
YouTube1 videos

AI synopsis

What people are saying

Discussions frequently mention the significance of the micropore in nutrient salvage, using terms like 'crucial' and 'new target,' which reflect strong support. The tone includes detailed references to specific proteins and pathways, suggesting deep engagement and recognition of the research's potential impact on medical advancements.

AgreementModerate agreement

Most discussions agree that the research provides valuable insights into Toxoplasma's nutrient acquisition mechanisms, with some expressing enthusiasm for its implications.

InterestHigh interest

Posts display high interest, often highlighting the novelty of the micropore’s role and the potential for new therapeutic targets.

EngagementModerate engagement

Several discussions delve into the details of the study, such as the importance of Kelch13 and ceramide pathways, indicating active engagement.

ImpactModerate impact

Participants generally believe this research could significantly influence future studies and strategies to combat parasitic infections.

Abstract in brief

The study focuses on how the Apicomplexan parasite Toxoplasma gondii acquires nutrients from host cells through a specialized structure called the micropore.
Researchers found that the micropore is crucial for endocytosis, allowing the parasite to take in nutrients from the host's cytoplasm and Golgi apparatus.
They identified a protein called Kelch13, which plays a key role at the micropore, and discovered that optimal function of this structure depends on a specific pathway for ceramide synthesis within the parasite.

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All mentions

Toxoplasma Micropore's Role in Nutrient Endocytosis from Host Cells

This video explores how Toxoplasma gondii acquires nutrients via the micropore, a specialized structure essential for endocytosis from host cell compartments. It highlights the role of Kelch13 protein and ceramide…

STEM RTCL TV · Jun 18, 2023 20 views

micropapers

@micro_papers · X

The Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments https://t.co/OADDNKGbKz

Feb 23, 2023 · 332 followers View post →