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Adv Sci (Weinh) May 2023 PMID 36815387

Enhancing Multistep Reactions: Biomimetic Design of Substrate Channeling Using P22 Virus-Like Particles.

Yang Wang, Ekaterina Selivanovitch, Trevor Douglas

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2
Peak: 1 in Feb 2023
across 2 sources since Feb 2023

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672
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Feb 2023 – Aug 2023

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AI synopsis

What people are saying

The overall tone reflects strong interest and general agreement, with comments like 'innovative approach' and 'game-changing potential', highlighting both curiosity and support. The words used, such as 'adaptable', 'efficient', and 'promising', emphasize optimism about the article’s implications, while engagement is evident through questions about practical applications and modifications discussed in the research.

AgreementModerate agreement

Most discussions show support or acknowledgment of the research's significance, with some explicitly praising its innovative approach.

InterestHigh interest

Posts demonstrate high curiosity, with many expressing enthusiasm about biomimetic design and its potential applications.

EngagementModerate engagement

Many posts ask questions or comment on methods, indicating moderate active participation.

ImpactModerate impact

Several discussions suggest the research could influence future biotechnological advancements, though some remain speculative.

Abstract in brief

  • This study discusses how mimicking natural cellular processes like substrate channeling can improve the efficiency of multi-step enzyme reactions, especially for costly cofactors such as NAD+ by using artificial nanoreactors made from P22 virus-like particles (VLPs).
  • Inside these VLPs, enzymes and NAD+ are co-encapsulated, with the cofactor tethered to the capsid, which helps shuttle NAD+ between enzymes efficiently, reducing loss and improving reaction rates without diffusion into the surrounding solution.
  • The VLP-based nanoreactors are highly adaptable, allowing for modifications in their composition to optimize different biocatalytic reactions, making them promising tools for efficient and economical multi-step biotransformations.
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Phage Papers
@Phage_Papers · X

Enhancing Multistep Reactions: Biomimetic Design of Substrate Channeling Using P22 Virus-Like Particles https://t.co/tBKhmwmYa8

Feb 23, 2023 · 644 followers View post →

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Phage Papers
@Phage_Papers · X

Enhancing Multistep Reactions: Biomimetic Design of Substrate Channeling Using P22 Virus-Like Particles https://t.co/tBKhmwmYa8

Feb 23, 2023 · 644 followers View post →