Nat Commun February 2023 PMID 36828807

Citrullination modulates antigen processing and presentation by revealing cryptic epitopes in rheumatoid arthritis.

Ashley M Curran, Alexander A Girgis, Yura Jang, Jonathan D Crawford, Mekha A Thomas, Ryan Kawalerski, Jeff Coller, Clifton O Bingham, Chan Hyun Na, Erika Darrah

Full text PDF Download social card

Mentions

Peak: 9 in Feb 2023

across 2 sources since Feb 2023

Extended reach

35,406

potential audience

Total likes

Video views

117

Mentions per month

Feb 2023 – Nov 2023

Where it's discussed

X / Twitter10 posts
YouTube1 videos

AI synopsis

What people are saying

The overall tone reflects curiosity and recognition of the research's importance, exemplified by phrases like 'Citrullination modulates antigen processing' and references to labs and conferences, demonstrating active interest without deep critique or debate.

AgreementModerate agreement

Most discussions acknowledge the significance of the study and its focus on citrullination's role in RA, indicating general agreement with the publication's findings.

InterestHigh interest

Posts exhibit high interest by highlighting the novelty and implications of the research, such as 'fave topic' and referencing specific labs and studies.

EngagementModerate engagement

There is moderate engagement, with references to related laboratories and ongoing research, but limited in-depth analysis or critique.

ImpactModerate impact

While the discussions recognize the importance of understanding autoimmune mechanisms, there is cautious optimism about potential clinical impact rather than definitive conclusions.

Abstract in brief

Citrullination, a process where arginine residues are converted to citrullines, changes how proteins are broken down and presented by immune cells, revealing hidden cryptic peptides that may trigger autoimmune responses in rheumatoid arthritis (RA).
This modification mainly causes alterations in protein structure and cleavage, leading to a unique set of peptides that stimulate T cells from RA patients more effectively than those from healthy individuals, contributing to the loss of immune tolerance.
The study suggests that citrullination does not directly present citrulline-containing epitopes but instead destabilizes proteins and changes protease activity, uncovering cryptic peptides that may drive autoimmunity in RA.]

Read the full abstract

All mentions

Citrullination and its Role in Autoimmune Response in Rheumatoid Arthritis

Citrullination modifies protein processing and presentation by immune cells, revealing hidden peptides that may trigger autoimmunity in rheumatoid arthritis. This process alters protein stability and cleavage…

STEM RTCL TV · Jun 14, 2023 117 views

Rheum Cat

@rheum_cat · X

@UWRheum Next section, Dr Mustelin’s fave topic: citrullination in RA Work from the Darrah lab: https://t.co/I1TnhVpKQc #ACR23 https://t.co/Az8if1yTYL

Nov 13, 2023 · 8,920 followers View post →

Jen Li

@DrJenLi_Renal · X