Detection of Streptococcus pyogenes M1 in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA.

Mark R Davies, Nadia Keller, Stephan Brouwer, Magnus G Jespersen, Amanda J Cork, Andrew J Hayes, Miranda E Pitt, David M P De Oliveira, Nichaela Harbison-Price, Olivia M Bertolla, Daniel G Mediati, Bodie F Curren, George Taiaroa, Jake A Lacey, Helen V Smith

February 2023 Nat Commun

Synopsis of Social media discussions

Discussants generally recognize the importance of the identified mutation driving increased SpeA expression, noting its potential to influence infection severity and disease spread. Words like 'significant', 'mutation', and 'monitoring' highlight a serious tone, emphasizing both scientific curiosity and public health concern, while the level of detailed analysis shows active engagement.

A
Agreement
 Moderate agreement

Most discussions acknowledge the significance of identifying the new M1UK variant and its implications for public health.

I
Interest
 Moderate level of interest

Participants show moderate curiosity, focusing on the mutation details and potential future risks, which indicates some engagement with the scientific findings.

E
Engagement
 High engagement

Several social discussions delve into the genetic mechanisms and public health responses, suggesting a relatively deep level of engagement.

I
Impact
 Moderate level of impact

The conversations reflect awareness of the broader implications for disease monitoring and outbreak prevention, although some see it as an incremental advance rather than transformative.

Social Mentions

YouTube

1 Videos

Twitter

2 Posts

News

21 Articles

Reddit

2 Posts

Metrics

Video Views

548

Total Likes

1

Extended Reach

714

Social Features

26

Timeline: Posts about article

Top Social Media Posts

Posts referencing the article

Detection and Characterization of Streptococcus pyogenes M1UK Variant in Australia

Detection and Characterization of Streptococcus pyogenes M1UK Variant in Australia

This video discusses the identification of the Streptococcus pyogenes M1UK variant in Australia and a mutation associated with increased superantigen SpeA expression, highlighting the importance of monitoring emerging bacterial strains globally.

STEM RTCL TV

June 16, 2023

548 views

  • GCH papers
    @GCHpapers (Twitter)

    Detection of Streptococcus pyogenes M1UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA https://t.co/8pknH0FMJx
    view full post

    February 25, 2023

  • gchlthpapers
    @gchlthpapers (Twitter)

    Detection of Streptococcus pyogenes M1UK in Australia and characterization of the mutation driving enhanced expression of superantigen SpeA https://t.co/lJj1lyVhKd
    view full post

    February 25, 2023

Abstract Synopsis

  • A new variant of Streptococcus pyogenes serotype M1 has been identified in the UK, linked to increases in scarlet fever cases and invasive infections due to its enhanced SpeA superantigen expression.
  • This M1 variant can be distinguished from its predecessor by specific genetic mutations but the reason for the increased SpeA expression remains unclear.
  • Researchers found that a single genetic change in the ssrA gene leads to higher SpeA expression in the M1 lineage in Australia, signaling a need for better global monitoring of such variants.