Int J Mol Sci February 2023 PMID 36835540

Spermidine-Eugenol Supplement Preserved Inflammation-Challenged Intestinal Cells by Stimulating Autophagy.

Francesca Truzzi, Anne Whittaker, Eros D'Amen, Maria Chiara Valerii, Veronika Abduazizova, Enzo Spisni, Giovanni Dinelli

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Mentions

Peak: 6 in Apr 2023

across 2 sources since Feb 2023

Extended reach

173,015

potential audience

Total likes

Video views

357

Mentions per month

Feb 2023 – Jan 2026

Where it's discussed

X / Twitter14 posts
YouTube2 videos

AI synopsis

What people are saying

The discussions mainly revolve around the scientific findings, with posts emphasizing the role of spermidine and eugenol in autophagy and inflammation reduction, using words like 'preserved' and 'rejuvenate' to express both interest and curiosity. The tone fluctuates from supportive to inquisitive, reflecting a mix of scientific appreciation and ongoing questions about practical applications.

AgreementModerate agreement

Most discussions recognize the potential benefits of the supplement, with some questions about its rejuvenating effects, indicating broad support but some skepticism.

InterestHigh interest

The posts display high curiosity about the supplement's mechanisms and implications, especially with questions like 'Can our bodies be rejuvenated with spermidine?'

EngagementModerate engagement

Participants reference the study's details, such as autophagy stimulation and reproducibility features, showing thoughtful engagement.

ImpactModerate impact

While the discussions highlight interest in potential applications and scientific rigor, they do not indicate widespread recognition of immediate or transformative impact.

Abstract in brief

The study investigates how a supplement containing spermidine (SPD) from wheatgerm and eugenol (EUG) from cloves can reduce inflammation and promote autophagy in intestinal cells, especially after exposure to inflammatory triggers like LPS.
The supplement was found to lower harmful reactive oxygen species (ROS), reduce inflammation markers like midkine, and increase beneficial functions such as mucus production and cell barrier integrity. It also stimulated different forms of autophagy, which helps cells clear damaged components and maintain health.
Even when autophagy was blocked, the supplement still reduced inflammation, indicating it might work through multiple pathways to support gut health and could be useful in treating chronic inflammatory diseases.

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All mentions

Spermidine and Dendrobium Officinale for Anti-Aging Benefits

This video explores the role of spermidine in autophagy and longevity, highlighting the importance of optimal spermidine levels for health. It covers fasting, autophagy, dietary sources, supplements, and relevant tests…

Minuto Naturologia · Jan 3, 2026 180 views

The Role of Spermidine and Natural Sources in Autophagy and Longevity

Intermittent fasting benefits health, but maintaining healthy spermidine levels is key. Learn about natural sources of spermidine and its crucial role in autophagy and lifespan extension, supported by scientific…

Minuto Naturologia · Jan 5, 2026 177 views

AntiAgify - Science will set you free

@AntiAgify · X

RT @DrPalmquist: Spermidine-Eugenol Supplement Preserved Inflammation-Challenged Intestinal Cells by Stimulating Autophagy https://t.co/CY2…

Jun 15, 2023 · 1 share · 1,338 followers View post →

DrRPalmquist

@DrPalmquist · X

Spermidine-Eugenol Supplement Preserved Inflammation-Challenged Intestinal Cells by Stimulating Autophagy https://t.co/CY2fl9pdt6

Jun 15, 2023 · 2 likes · 1 share · 3,151 followers View post →

Reiner 

@erlesen · X