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The discussions show enthusiasm for the new conformational biases introduced by BSMs, with posts emphasizing how these advances make peptide helix enforcement easier and more efficient. The tone suggests appreciation for the methodological progress, exemplified by phrases like 'impressive conformational biases' and 'a game changer,' which reflect both high interest and perceived impact.
Most discussions express strong agreement with the significance and breakthrough nature of the research.
Posts demonstrate high interest, highlighting new methods and potential applications.
Participants reference specific techniques and implications, showing moderate depth of engagement.
Several posts suggest the research could influence peptide design and peptide-based therapies, indicating a moderate level of impact.
It used to be hard to enforce peptide helices via C-terminal cap, but now it can be done with impressive conformational biases using Bicyclic Schellman Mimics (BSMs). NEW #ASAP by @KevinBurgessLab Read it here: https://t.co/YrjymkAUKR https://t.co/opZ0yxSxi9
RT @ACSCentSci: It used to be hard to enforce peptide helices via C-terminal cap, but now it can be done with impressive conformational bia…
Research on bicyclic N-caps as alternatives to stapling for helical constraints. This video covers Bicyclic ASX Motif Mimics BAMMs and related studies, highlighting methods to enforce peptide helicity and related…
This work discusses a new method called DualCapped Helical Interface that stabilizes helices with specialized caps, improving stability and cell uptake. The approach uses bicyclic caps at both ends, making mimics more…
RT @ACSCentSci: It used to be hard to enforce peptide helices via C-terminal cap, but now it can be done with impressive conformational bia…
It used to be hard to enforce peptide helices via C-terminal cap, but now it can be done with impressive conformational biases using Bicyclic Schellman Mimics (BSMs). NEW #ASAP by @KevinBurgessLab Read it here: https://t.co/YrjymkAUKR https://t.co/opZ0yxSxi9