Designing Single-Atom Active Sites on sp -Carbon Linked Covalent Organic Frameworks to Induce Bacterial Ferroptosis-Like for Robust Anti-Infection Therapy.

Abstract in brief

• The study introduces a new antibacterial approach that induces a form of cell death called ferroptosis-like, which helps overcome drug resistance in bacteria, by using single-atom metal sites (like Ir and Ru) embedded in covalent organic frameworks that target both Gram-positive and Gram-negative bacteria, including resistant strains like MRSA.
• These single-atom catalysts (SACs) can be activated by light or hydrogen peroxide to produce reactive oxygen species, deplete protective enzymes, and disrupt bacterial metabolism, resulting in damaging lipid peroxidation that kills the bacteria.
• The strategy shows strong antibacterial effects, including against biofilms and resistant bacteria, with good biocompatibility, making it a promising new method for treating tough infections like MRSA in wounds and abscesses.]