Neuropsychopharmacol Rep June 2023 PMID 36847164

Jitteriness/anxiety syndrome caused by coadministration of celecoxib, a selective COX-2 inhibitor, with escitalopram and trazodone in a patient with depression and spondylolisthesis.

Toshinori Shirata, Shinji Yano, Keisuke Noto, Muneaki Kanno, Akihito Suzuki

Mentions

2
Peak: 1 in Feb 2023
across 2 sources since Feb 2023

Extended reach

386
potential audience

Total likes

1

Video views

201

Mentions per month

Feb 2023 – Sep 2023

Where it's discussed

  • X / Twitter1 posts
  • YouTube1 videos

AI synopsis

What people are saying

The overall discussion reflects a moderate but attentive engagement with the case report, with examples like users noting the symptom onset after drug addition and emphasizing the importance of understanding drug interactions; words like 'important,' 'link,' and 'clinical implications' illustrate a responsible tone that underscores the relevance of the findings.

AgreementModerate agreement

Most discussion participants agree that the case report highlights an important drug interaction concern, as seen in comments supporting the link between celecoxib and jitteriness symptoms.

InterestModerate interest

The discussions show moderate interest, with users expressing curiosity about the clinical implications and potential side effects, but not deeply exploring mechanistic details.

EngagementModerate engagement

Participants are actively discussing the case, referencing the timeline of symptom resolution and possible mechanisms, indicating a moderate level of engagement.

ImpactModerate impact

The discussions suggest that this report could influence clinical awareness and prescribing practices, highlighting its potential significance for healthcare providers.

Abstract in brief

  • The text describes a case where a woman in her 60s experienced jitteriness-anxiety syndrome, characterized by symptoms like anxiety, agitation, and hypomania, after starting celecoxib alongside her existing antidepressants, escitalopram and trazodone.
  • The symptoms appeared immediately after the addition of celecoxib and resolved once the drug was discontinued, suggesting a link between the medication combination and the syndrome.
  • The case indicates that coadministering celecoxib with certain antidepressants may cause jitteriness-anxiety syndrome possibly due to pharmacokinetic interactions or effects on serotonin pathways.]

Top posts

Most liked on X and Bluesky
Neuropsychopharmacology Reports (NPPR)
@NPPR_JSNP · X

New Case report: Jitteriness/anxiety syndrome caused by coadministration of celecoxib, a selective COX-2 inhibitor, with escitalopram and trazodone in a patient with depression and spondylolisthesis https://t.co/MH6Bh41qod

Feb 27, 2023 · 185 followers View post →

All mentions

Neuropsychopharmacology Reports (NPPR)
@NPPR_JSNP · X

New Case report: Jitteriness/anxiety syndrome caused by coadministration of celecoxib, a selective COX-2 inhibitor, with escitalopram and trazodone in a patient with depression and spondylolisthesis https://t.co/MH6Bh41qod

Feb 27, 2023 · 185 followers View post →