Am J Psychiatry April 2023 PMID 36856707

Polygenic Scores and Onset of Major Mood or Psychotic Disorders Among Offspring of Affected Parents.

Alyson Zwicker, Janice M Fullerton, Niamh Mullins, Frances Rice, Danella M Hafeman, Neeltje E M van Haren, Nikita Setiaman, John A Merranko, Benjamin I Goldstein, Alessandra G Ferrera, Emma K Stapp, Elena de la Serna, Dolores Moreno, Gisela Sugranyes, Sergio Mas Herrero

Mentions

68
Peak: 49 in Feb 2023
across 2 sources since Feb 2023

Extended reach

200,751
potential audience

Total likes

156

Video views

102

Mentions per month

Feb 2023 – Apr 2023

Where it's discussed

  • X / Twitter66 posts
  • YouTube2 videos

AI synopsis

What people are saying

The discussions predominantly reflect strong enthusiasm for the research, with comments praising the potential of neuroticism and subjective well-being polygenic scores in predicting mental disorders, exemplified by phrases like 'powerful predictor' and 'may aid early identification'. The tone is optimistic and engaged, with references to supplementary materials and the authors' contributions, showing a keen interest in the detailed scientific findings.

AgreementModerate agreement

Most discussions appear positive, emphasizing the importance and potential of polygenic scores in predicting mental health risks.

InterestHigh interest

Many posts express enthusiasm and curiosity about the research's implications, indicating high interest.

EngagementHigh engagement

Posts include detailed mentions of specific findings, methods, and future applications, reflecting deep engagement.

ImpactModerate impact

The discussions highlight the significance of the research for early detection and intervention, suggesting a noteworthy impact.

Abstract in brief

  • The study examined whether polygenic scores (PGSs), which measure genetic risk, can improve the prediction of major mood and psychotic disorders in people with a family history of such illnesses.
  • Results showed that PGSs for neuroticism and subjective wellbeing are linked to disorder onset independently of family history, with neuroticism increasing risk and subjective wellbeing decreasing it, while PGSs for other psychiatric conditions added limited predictive value when family history was known.
  • Overall, neuroticism and subjective wellbeing PGSs could help identify high-risk individuals earlier and better complement family history for mental health risk assessment.

Top posts

Most liked on X and Bluesky
Rudolf Uher
@RudolfUher · X

Which polygenic score is the best predictor of major mood and psychotic disorders in youth? #neuroticism is the unlikely winner. https://t.co/kVwig3zMaF https://t.co/tXp9TWVBwT

Feb 23, 2023 · 52 likes · 17 shares · 1,595 followers View post →
Rudolf Uher
@RudolfUher · X

Polygenic scores add to family history to better predict which young people are at risk for mental illness #depression #bipolar #psychosis https://t.co/kVwig3zMaF https://t.co/J4HTPVIZPX

Feb 22, 2023 · 35 likes · 11 shares · 1,595 followers View post →
Rudolf Uher
@RudolfUher · X

As with most good papers, the really interesting results are in the #SupplementaryMaterial Polygenic scores carry two thirds of the predictive power of family history in predicting mental illness https://t.co/kVwig3zMaF https://t.co/ECV5Nv6zaE

Feb 24, 2023 · 14 likes · 4 shares · 1,595 followers View post →
Alyson Zwicker
@AlysonZwicker · X

So excited to share our latest paper - it has been in the works since I was just a baby MSc student!

Feb 22, 2023 · 10 likes · 3 shares · 120 followers View post →
Genome Atlantic
@GenomeAtlantic · X

Congratulations (!!!) Drs. @RudolfUher & Martin Alda @Dal_Psychiatry whose paper on @GenomeAtlantic supported research in genetics & mental illness has been published in the American Journal of Psychiatry https://t.co/2pQPtOSWMx @GenomeCanada @HealthNS @DalMedSchool https://t.co/eeL63PkKNp

Feb 22, 2023 · 9 likes · 4 shares · 2,011 followers View post →
Jan Fullerton
@FullertonJan · X

Happy to share work of our team @neuraustralia @UNSWMedicine with @RudolfUher @AlysonZwicker showing neuroticism & wellbeing PGS capture risk of new onset psychiatric disorders independent of family history & may aid early identification - online today! https://t.co/iwIDD2oGO5 https://t.co/2Kmk2Jv8AY

Feb 22, 2023 · 9 likes · 3 shares · 106 followers View post →

All mentions

DR.GUILLERMO VALIENTE Rodríguez
@Drvaliente · X

RT @APAPubJournals: 4. “Polygenic Scores and Onset of Major Mood or Psychotic Disorders Among Offspring of Affected Parents,” by Alyson Zwi…

Apr 24, 2023 · 1 share · 1,465 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

4. “Polygenic Scores and Onset of Major Mood or Psychotic Disorders Among Offspring of Affected Parents,” by Alyson Zwicker, Ph.D., et al. 4/4 https://t.co/HdC2cSxBK3

Apr 24, 2023 · 1 like · 1 share · 11,606 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

Polygenic Scores and Onset of Major Mood or Psychotic Disorders Among Offspring of Affected Parents https://t.co/HdC2cSxBK3

Apr 14, 2023 · 11,606 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

AJP Deputy Editor Danny Pine highlights two articles from the March 2023 issue. https://t.co/Ua3jvjLzwE

Apr 14, 2023 · 11,606 followers View post →
Topher Hübel
@topherhuebel · X

RT @RudolfUher: Which polygenic score is the best predictor of major mood and psychotic disorders in youth? #neuroticism is the unlikely w…

Apr 1, 2023 · 17 shares · 1,665 followers View post →
Dr Emma
@embws · X

RT @neuraustralia: This #WorldBipolarDay we want to highlight our research lead Associate Professor @FullertonJan, who recently co-authored…

Mar 30, 2023 · 1 share · 3,044 followers View post →
NeuRA (Neuroscience Research Australia)
@neuraustralia · X

This #WorldBipolarDay we want to highlight our research lead Associate Professor @FullertonJan, who recently co-authored a paper on genetic indexes in predicting onset of major mental illness in young people.

Mar 30, 2023 · 1 like · 1 share · 5,455 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

RT @RudolfUher: Which polygenic score is the best predictor of major mood and psychotic disorders in youth? #neuroticism is the unlikely w…

Mar 7, 2023 · 17 shares · 11,606 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

RT @AlysonZwicker: So excited to share our latest paper - it has been in the works since I was just a baby MSc student!

Mar 7, 2023 · 3 shares · 11,606 followers View post →
CopperKettle
@Artyom_Yekat · X

RT @bogglerapture: Polygenic Scores and Onset of Major Mood or Psychotic Disorders Among Offspring of Affected Parents https://t.co/7jNlGPa…

Mar 4, 2023 · 1 share · 380 followers View post →
Armin Raznahan
@bogglerapture · X

Polygenic Scores and Onset of Major Mood or Psychotic Disorders Among Offspring of Affected Parents https://t.co/7jNlGPa4Xm

Mar 4, 2023 · 7 likes · 1 share · 2,206 followers View post →
Graham Murray (@gkmurray.bsky.social)
@gk_murray · X

RT @AlysonZwicker: So excited to share our latest paper - it has been in the works since I was just a baby MSc student!

Mar 1, 2023 · 3 shares · 1,432 followers View post →
Prof Helen L. Fisher
@HelenLFisher · X

RT @RudolfUher: On predicting mental illness from polygenic scores. The best summary is in this thread by the first author Dr @AlysonZwic…

Mar 1, 2023 · 3 shares · 3,683 followers View post →
Helena Lundbäck
@HLunsan · X

RT @RudolfUher: On predicting mental illness from polygenic scores. The best summary is in this thread by the first author Dr @AlysonZwic…

Mar 1, 2023 · 3 shares · 2,761 followers View post →
neuropsychgenpapers
@neuropsychgenp1 · X

Polygenic Scores and Onset of Major Mood or Psychotic Disorders Among Offspring of Affected Parents https://t.co/kAsclPefEi https://t.co/FtISCTVPcW

Mar 1, 2023 · 18 followers View post →
Amir Sariaslan
@AmirSariaslan · X

RT @RudolfUher: On predicting mental illness from polygenic scores. The best summary is in this thread by the first author Dr @AlysonZwic…

Mar 1, 2023 · 3 shares · 20,203 followers View post →
Rudolf Uher
@RudolfUher · X

On predicting mental illness from polygenic scores. The best summary is in this thread by the first author Dr @AlysonZwicker https://t.co/1s8RpgH4Kg https://t.co/n3drXGrT5D

Mar 1, 2023 · 6 likes · 3 shares · 1,595 followers View post →
Rudolf Uher
@RudolfUher · X

@OskarJefsen Well observed. There was a significant interaction between neuroticism and family history. Neuroticism PGS seems to accurately pick the onsets among those without known family history. It is in the Results section https://t.co/kVwig3zMaF

Feb 25, 2023 · 1 like · 1,595 followers View post →
Thomas Reilly
@Rational_Psych · X

RT @RudolfUher: As with most good papers, the really interesting results are in the #SupplementaryMaterial Polygenic scores carry two thir…

Feb 25, 2023 · 4 shares · 1,328 followers View post →
Julian Mutz
@julianmutz · X

RT @RudolfUher: As with most good papers, the really interesting results are in the #SupplementaryMaterial Polygenic scores carry two thir…

Feb 25, 2023 · 4 shares · 527 followers View post →
Woo-Young (Young) Ahn
@wooyoungahn · X

RT @RudolfUher: Which polygenic score is the best predictor of major mood and psychotic disorders in youth? #neuroticism is the unlikely w…

Feb 24, 2023 · 17 shares · 894 followers View post →
Adam Chekroud
@drchekkers · X

RT @RudolfUher: As with most good papers, the really interesting results are in the #SupplementaryMaterial Polygenic scores carry two thir…

Feb 24, 2023 · 4 shares · 3,353 followers View post →
Claudia_La
@ClLazarides · X

RT @RudolfUher: Which polygenic score is the best predictor of major mood and psychotic disorders in youth? #neuroticism is the unlikely w…

Feb 24, 2023 · 17 shares · 818 followers View post →
Esme Elsden
@ElsdenEsme · X

RT @RudolfUher: As with most good papers, the really interesting results are in the #SupplementaryMaterial Polygenic scores carry two thir…

Feb 24, 2023 · 4 shares · 415 followers View post →
Kathryn Freeman
@kat3fr33man · X

RT @RudolfUher: Which polygenic score is the best predictor of major mood and psychotic disorders in youth? #neuroticism is the unlikely w…

Feb 24, 2023 · 17 shares · 14 followers View post →
Rudolf Uher
@RudolfUher · X

As with most good papers, the really interesting results are in the #SupplementaryMaterial Polygenic scores carry two thirds of the predictive power of family history in predicting mental illness https://t.co/kVwig3zMaF https://t.co/ECV5Nv6zaE

Feb 24, 2023 · 14 likes · 4 shares · 1,595 followers View post →
Rudolf Uher
@RudolfUher · X

Polygenic score for #neuroticism had a large sample to draw on. This may be why it powerful in predicting even sever types of mental illness. https://t.co/kVwig3zMaF https://t.co/XcYDgNhn1q

Feb 24, 2023 · 4 likes · 1,595 followers View post →
Laurence Astill Wright
@laurence_aw · X

RT @RudolfUher: Which polygenic score is the best predictor of major mood and psychotic disorders in youth? #neuroticism is the unlikely w…

Feb 24, 2023 · 17 shares · 303 followers View post →
Ryuhei So
@RyuheiSo · X

RT @RudolfUher: Which polygenic score is the best predictor of major mood and psychotic disorders in youth? #neuroticism is the unlikely w…

Feb 23, 2023 · 17 shares · 993 followers View post →
Eric Phillips
@eric_m_phillips · X

RT @RudolfUher: Which polygenic score is the best predictor of major mood and psychotic disorders in youth? #neuroticism is the unlikely w…

Feb 23, 2023 · 17 shares · 601 followers View post →
NeuRA (Neuroscience Research Australia)
@neuraustralia · X

RT @RudolfUher: Which polygenic score is the best predictor of major mood and psychotic disorders in youth? #neuroticism is the unlikely w…

Feb 23, 2023 · 17 shares · 5,455 followers View post →
Dr Giorgia Michelini (she/her) (inactive account)
@GiorgiaMiche · X

RT @RudolfUher: Which polygenic score is the best predictor of major mood and psychotic disorders in youth? #neuroticism is the unlikely w…

Feb 23, 2023 · 17 shares · 1,521 followers View post →
Laurence Astill Wright
@laurence_aw · X

RT @RudolfUher: Polygenic scores add to family history to better predict which young people are at risk for mental illness #depression #bip…

Feb 23, 2023 · 11 shares · 303 followers View post →
Alyson Zwicker
@AlysonZwicker · X

RT @RudolfUher: Which polygenic score is the best predictor of major mood and psychotic disorders in youth? #neuroticism is the unlikely w…

Feb 23, 2023 · 17 shares · 120 followers View post →
Peter Hitchcock
@PF_Hitchcock · X

RT @RudolfUher: Which polygenic score is the best predictor of major mood and psychotic disorders in youth? #neuroticism is the unlikely w…

Feb 23, 2023 · 17 shares · 1,330 followers View post →
Esme Elsden
@ElsdenEsme · X

RT @RudolfUher: Which polygenic score is the best predictor of major mood and psychotic disorders in youth? #neuroticism is the unlikely w…

Feb 23, 2023 · 17 shares · 415 followers View post →
priya joseph
@ayirpelle · X

RT @RudolfUher: Which polygenic score is the best predictor of major mood and psychotic disorders in youth? #neuroticism is the unlikely w…

Feb 23, 2023 · 17 shares · 4,986 followers View post →
Traitwell
@traitwell · X

RT @RudolfUher: Which polygenic score is the best predictor of major mood and psychotic disorders in youth? #neuroticism is the unlikely w…

Feb 23, 2023 · 17 shares · 603 followers View post →
Dr Vicky Powell
@VickyPowellPhD · X

RT @RudolfUher: Which polygenic score is the best predictor of major mood and psychotic disorders in youth? #neuroticism is the unlikely w…

Feb 23, 2023 · 17 shares · 330 followers View post →
Dr Cathryn Lewis
@cathrynlewis · X

RT @RudolfUher: Which polygenic score is the best predictor of major mood and psychotic disorders in youth? #neuroticism is the unlikely w…

Feb 23, 2023 · 17 shares · 7,987 followers View post →
Rudolf Uher
@RudolfUher · X

Which polygenic score is the best predictor of major mood and psychotic disorders in youth? #neuroticism is the unlikely winner. https://t.co/kVwig3zMaF https://t.co/tXp9TWVBwT

Feb 23, 2023 · 52 likes · 17 shares · 1,595 followers View post →
Mirko
@MirkoManchia · X

RT @RudolfUher: Polygenic scores add to family history to better predict which young people are at risk for mental illness #depression #bip…

Feb 23, 2023 · 11 shares · 203 followers View post →
Dr Vicky Powell
@VickyPowellPhD · X

RT @RudolfUher: Polygenic scores add to family history to better predict which young people are at risk for mental illness #depression #bip…

Feb 23, 2023 · 11 shares · 330 followers View post →
Austin Lam
@austinaldenlam · X

Polygenic Scores and Onset of Major Mood or Psychotic Disorders Among Offspring of Affected Parents https://t.co/n8W0goymuA

Feb 23, 2023 · 1,084 followers View post →
UNSW Medicine & Health
@UNSWMedicine · X

RT @FullertonJan: Happy to share work of our team @neuraustralia @UNSWMedicine with @RudolfUher @AlysonZwicker showing neuroticism & wellbe…

Feb 22, 2023 · 3 shares · 5,414 followers View post →
Emma K Stapp
@emmakstapp · X

RT @FullertonJan: Happy to share work of our team @neuraustralia @UNSWMedicine with @RudolfUher @AlysonZwicker showing neuroticism & wellbe…

Feb 22, 2023 · 3 shares · 183 followers View post →
Wei Cheng
@WeiFDU · X

RT @RudolfUher: Polygenic scores add to family history to better predict which young people are at risk for mental illness #depression #bip…

Feb 22, 2023 · 11 shares · 442 followers View post →
NeuRA (Neuroscience Research Australia)
@neuraustralia · X

RT @FullertonJan: Happy to share work of our team @neuraustralia @UNSWMedicine with @RudolfUher @AlysonZwicker showing neuroticism & wellbe…

Feb 22, 2023 · 3 shares · 5,455 followers View post →
Benjamin Goldstein
@bengoldstein73 · X

RT @RudolfUher: Polygenic scores add to family history to better predict which young people are at risk for mental illness #depression #bip…

Feb 22, 2023 · 11 shares · 708 followers View post →
Jan Fullerton
@FullertonJan · X

Happy to share work of our team @neuraustralia @UNSWMedicine with @RudolfUher @AlysonZwicker showing neuroticism & wellbeing PGS capture risk of new onset psychiatric disorders independent of family history & may aid early identification - online today! https://t.co/iwIDD2oGO5 https://t.co/2Kmk2Jv8AY

Feb 22, 2023 · 9 likes · 3 shares · 106 followers View post →
Jan Fullerton
@FullertonJan · X

RT @RudolfUher: Polygenic scores add to family history to better predict which young people are at risk for mental illness #depression #bip…

Feb 22, 2023 · 11 shares · 106 followers View post →
M Herrera-Rivero
@HerreraR_biomed · X

RT @RudolfUher: Polygenic scores add to family history to better predict which young people are at risk for mental illness #depression #bip…

Feb 22, 2023 · 11 shares · 177 followers View post →
M Herrera-Rivero
@HerreraR_biomed · X

RT @APAPubJournals: Polygenic scores for neuroticism and subjective well-being predict the risk of major mental illness independently of fa…

Feb 22, 2023 · 3 shares · 177 followers View post →
Genome Canada
@GenomeCanada · X

RT @GenomeAtlantic: Congratulations (!!!) Drs. @RudolfUher & Martin Alda @Dal_Psychiatry whose paper on @GenomeAtlantic supported research…

Feb 22, 2023 · 4 shares · 11,295 followers View post →
Alyson Zwicker
@AlysonZwicker · X

RT @APAPubJournals: Polygenic scores for neuroticism and subjective well-being predict the risk of major mental illness independently of fa…

Feb 22, 2023 · 3 shares · 120 followers View post →
Dal_Psychiatry
@Dal_Psychiatry · X

RT @GenomeAtlantic: Congratulations (!!!) Drs. @RudolfUher & Martin Alda @Dal_Psychiatry whose paper on @GenomeAtlantic supported research…

Feb 22, 2023 · 4 shares · 443 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

Polygenic scores for neuroticism and subjective well-being predict the risk of major mental illness independently of family history. https://t.co/tiCsZvv8pc https://t.co/rKNt4cGCsP

Feb 22, 2023 · 5 likes · 3 shares · 11,606 followers View post →
DalMedSchool
@DalMedSchool · X

RT @GenomeAtlantic: Congratulations (!!!) Drs. @RudolfUher & Martin Alda @Dal_Psychiatry whose paper on @GenomeAtlantic supported research…

Feb 22, 2023 · 4 shares · 5,674 followers View post →
Genome Atlantic
@GenomeAtlantic · X

Congratulations (!!!) Drs. @RudolfUher & Martin Alda @Dal_Psychiatry whose paper on @GenomeAtlantic supported research in genetics & mental illness has been published in the American Journal of Psychiatry https://t.co/2pQPtOSWMx @GenomeCanada @HealthNS @DalMedSchool https://t.co/eeL63PkKNp

Feb 22, 2023 · 9 likes · 4 shares · 2,011 followers View post →
Katerina Dikaios
@kdikaios · X

RT @AlysonZwicker: So excited to share our latest paper - it has been in the works since I was just a baby MSc student!

Feb 22, 2023 · 3 shares · 121 followers View post →
Emily Howes Vallis
@E_HowesVallis · X

RT @RudolfUher: Polygenic scores add to family history to better predict which young people are at risk for mental illness #depression #bip…

Feb 22, 2023 · 11 shares · 121 followers View post →
Jibran Khokhar
@DrJKhokhar · X

RT @RudolfUher: Polygenic scores add to family history to better predict which young people are at risk for mental illness #depression #bip…

Feb 22, 2023 · 11 shares · 10,955 followers View post →
Alyson Zwicker
@AlysonZwicker · X

Feb 22, 2023 · 2 likes · 120 followers View post →
Dal_Psychiatry
@Dal_Psychiatry · X

RT @RudolfUher: Polygenic scores add to family history to better predict which young people are at risk for mental illness #depression #bip…

Feb 22, 2023 · 11 shares · 443 followers View post →
Alyson Zwicker
@AlysonZwicker · X

So excited to share our latest paper - it has been in the works since I was just a baby MSc student!

Feb 22, 2023 · 10 likes · 3 shares · 120 followers View post →
Rudolf Uher
@RudolfUher · X

Polygenic scores add to family history to better predict which young people are at risk for mental illness #depression #bipolar #psychosis https://t.co/kVwig3zMaF https://t.co/J4HTPVIZPX

Feb 22, 2023 · 35 likes · 11 shares · 1,595 followers View post →