Mol Oncol July 2023 PMID 36862005

MicroRNA 483-3p overexpression unleashes invasive growth of metastatic colorectal cancer via NDRG1 downregulation and ensuing activation of the ERBB3/AKT axis.

Ermes Candiello, Gigliola Reato, Federica Verginelli, Gennaro Gambardella, Antonio D Ambrosio, Noemi Calandra, Francesca Orzan, Antonella Iuliano, Raffaella Albano, Francesco Sassi, Paolo Luraghi, Paolo M Comoglio, Andrea Bertotti, Livio Trusolino, Carla Boccaccio

Mentions

11
Peak: 7 in Apr 2023
across 3 sources since Mar 2023

Extended reach

12,818
potential audience

Total likes

13

Video views

14

Mentions per month

Mar 2023 – Oct 2023

Where it's discussed

  • X / Twitter8 posts
  • Blogs2 articles
  • YouTube1 videos

AI synopsis

What people are saying

Many comments praise the uncovering of new links between miRNA-483-3p and key signaling pathways, such as in the posts that mention 'unveiled a previously unrecognized link', and express pride in discovering potential therapies, using tone and words like 'unearth' and 'proud' which convey excitement and the importance of the findings.

AgreementModerate agreement

Most discussions express support for the study’s findings, emphasizing its significance in potential therapies and cancer progression understanding.

InterestHigh interest

Posts show high interest by highlighting new research connections and potential targeted treatments.

EngagementModerate engagement

Participants reference specific mechanisms like NDRG1 and ERBB3-AKT, demonstrating moderate engagement and curiosity about the biological pathways.

ImpactModerate impact

The discussions suggest the research is deemed influential, with comments on therapeutic potential and advances in understanding metastatic colorectal cancer.

Abstract in brief

  • MicroRNA 4833p overexpression promotes invasive and aggressive growth in metastatic colorectal cancer by downregulating NDRG1, a metastasis suppressor, which then activates the ERBB3-AKT signaling pathway.
  • The study shows that targeting ERBB3 with specific antibodies can counteract the invasive effects caused by miRNA4833p, highlighting a potential therapeutic approach.
  • In human tumors, high miRNA4833p levels are associated with low NDRG1, increased activation of EMT-related transcription factors, and poorer patient prognosis, linking this pathway to cancer progression.]

Top posts

Most liked on X and Bluesky
Intestinal Cell News
@Intestinal_Cell · X

A research team at the University of Turin led by Dr. Ermes Candiello (@Ermes_Mercury) unveiled a previously unrecognized link between miRNA-483-3p, NDRG1, and ERBB3-AKT signaling

Apr 11, 2023 · 7 likes · 1 share · 1,778 followers View post →
Ermes Candiello
@Ermes_Candiello · X

so proud to unearth new potential targeted therapies against metastatic dissemination #Fights #cancer #therapy #microrna #metastaticcolorectalcancer #metastasis @MolOncology @FEBSnews @Intestinal_Cell @transcriptomes FEBS Press https://t.co/8jqSrSV4JQ https://t.co/eT4m3Mer7N

Apr 7, 2023 · 5 likes · 3 shares · 5 followers View post →
RRID Robot
@RobotRrid · X

RRIDs were included in the Molecular Oncology paper "FEBS Press" (https://t.co/L8JZd84jNJ). Thank you for making your #methodsmatter. #reproducibility

Apr 14, 2023 · 1 like · 161 followers View post →
Bioinformatics Trends 
@BinfoTrends · X

RT @Ermes_Mercury: so proud to unearth new potential targeted therapies against metastatic dissemination #Fights #cancer #therapy #microrn…

Apr 7, 2023 · 3 shares · 8,163 followers View post →
Transcriptomes
@transcriptomes · X

MicroRNA 483-3p overexpression unleashes invasive growth of metastatic colorectal cancer via ... https://t.co/q5CbTVdP4M

Mar 3, 2023 · 1,809 followers View post →
Emanuele Franzoso
@EFranzoso · X

RT @Ermes_Mercury: so proud to unearth new potential targeted therapies against metastatic dissemination #Fights #cancer #therapy #microrn…

Apr 10, 2023 · 3 shares · 832 followers View post →

All mentions

RRID Robot
@RobotRrid · X

RRIDs were included in the Molecular Oncology paper "FEBS Press" (https://t.co/L8JZd84jNJ). Thank you for making your #methodsmatter. #reproducibility

Apr 14, 2023 · 1 like · 161 followers View post →
Ermes Candiello
@Ermes_Candiello · X

RT @Intestinal_Cell: A research team at the University of Turin led by Dr. Ermes Candiello (@Ermes_Mercury) unveiled a previously unrecogni…

Apr 11, 2023 · 1 share · 5 followers View post →
Intestinal Cell News
@Intestinal_Cell · X

A research team at the University of Turin led by Dr. Ermes Candiello (@Ermes_Mercury) unveiled a previously unrecognized link between miRNA-483-3p, NDRG1, and ERBB3-AKT signaling

Apr 11, 2023 · 7 likes · 1 share · 1,778 followers View post →
Emanuele Franzoso
@EFranzoso · X

RT @Ermes_Mercury: so proud to unearth new potential targeted therapies against metastatic dissemination #Fights #cancer #therapy #microrn…

Apr 10, 2023 · 3 shares · 832 followers View post →
Alessandro Scagliotti
@alescagliotti94 · X

RT @Ermes_Mercury: so proud to unearth new potential targeted therapies against metastatic dissemination #Fights #cancer #therapy #microrn…

Apr 7, 2023 · 3 shares · 24 followers View post →
Bioinformatics Trends 
@BinfoTrends · X

RT @Ermes_Mercury: so proud to unearth new potential targeted therapies against metastatic dissemination #Fights #cancer #therapy #microrn…

Apr 7, 2023 · 3 shares · 8,163 followers View post →
Ermes Candiello
@Ermes_Candiello · X

so proud to unearth new potential targeted therapies against metastatic dissemination #Fights #cancer #therapy #microrna #metastaticcolorectalcancer #metastasis @MolOncology @FEBSnews @Intestinal_Cell @transcriptomes FEBS Press https://t.co/8jqSrSV4JQ https://t.co/eT4m3Mer7N

Apr 7, 2023 · 5 likes · 3 shares · 5 followers View post →
Transcriptomes
@transcriptomes · X

MicroRNA 483-3p overexpression unleashes invasive growth of metastatic colorectal cancer via ... https://t.co/q5CbTVdP4M

Mar 3, 2023 · 1,809 followers View post →