A research team at the University of Turin led by Dr. Ermes Candiello (@Ermes_Mercury) unveiled a previously unrecognized link between miRNA-483-3p, NDRG1, and ERBB3-AKT signaling
MicroRNA 483-3p overexpression unleashes invasive growth of metastatic colorectal cancer via NDRG1 downregulation and ensuing activation of the ERBB3/AKT axis.
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Mar 2023 – Oct 2023Where it's discussed
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X / Twitter8 posts
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Blogs2 articles
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YouTube1 videos
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What people are saying
Many comments praise the uncovering of new links between miRNA-483-3p and key signaling pathways, such as in the posts that mention 'unveiled a previously unrecognized link', and express pride in discovering potential therapies, using tone and words like 'unearth' and 'proud' which convey excitement and the importance of the findings.
Most discussions express support for the study’s findings, emphasizing its significance in potential therapies and cancer progression understanding.
Posts show high interest by highlighting new research connections and potential targeted treatments.
Participants reference specific mechanisms like NDRG1 and ERBB3-AKT, demonstrating moderate engagement and curiosity about the biological pathways.
The discussions suggest the research is deemed influential, with comments on therapeutic potential and advances in understanding metastatic colorectal cancer.
Abstract in brief
- MicroRNA 4833p overexpression promotes invasive and aggressive growth in metastatic colorectal cancer by downregulating NDRG1, a metastasis suppressor, which then activates the ERBB3-AKT signaling pathway.
- The study shows that targeting ERBB3 with specific antibodies can counteract the invasive effects caused by miRNA4833p, highlighting a potential therapeutic approach.
- In human tumors, high miRNA4833p levels are associated with low NDRG1, increased activation of EMT-related transcription factors, and poorer patient prognosis, linking this pathway to cancer progression.]
Top posts
Most liked on X and Blueskyso proud to unearth new potential targeted therapies against metastatic dissemination #Fights #cancer #therapy #microrna #metastaticcolorectalcancer #metastasis @MolOncology @FEBSnews @Intestinal_Cell @transcriptomes FEBS Press https://t.co/8jqSrSV4JQ https://t.co/eT4m3Mer7N
RRIDs were included in the Molecular Oncology paper "FEBS Press" (https://t.co/L8JZd84jNJ). Thank you for making your #methodsmatter. #reproducibility
RT @Ermes_Mercury: so proud to unearth new potential targeted therapies against metastatic dissemination #Fights #cancer #therapy #microrn…
MicroRNA 483-3p overexpression unleashes invasive growth of metastatic colorectal cancer via ... https://t.co/q5CbTVdP4M
RT @Ermes_Mercury: so proud to unearth new potential targeted therapies against metastatic dissemination #Fights #cancer #therapy #microrn…
All mentions
MicroRNA 483-3p Promotes Invasive Growth in Metastatic Colorectal Cancer
MicroRNA 483-3p overexpression promotes aggressive growth in metastatic colorectal cancer by downregulating NDRG1, activating the ERBB3-AKT pathway. Targeting ERBB3 may offer therapeutic benefits, especially in high…
RRIDs were included in the Molecular Oncology paper "FEBS Press" (https://t.co/L8JZd84jNJ). Thank you for making your #methodsmatter. #reproducibility
RT @Intestinal_Cell: A research team at the University of Turin led by Dr. Ermes Candiello (@Ermes_Mercury) unveiled a previously unrecogni…
A research team at the University of Turin led by Dr. Ermes Candiello (@Ermes_Mercury) unveiled a previously unrecognized link between miRNA-483-3p, NDRG1, and ERBB3-AKT signaling
RT @Ermes_Mercury: so proud to unearth new potential targeted therapies against metastatic dissemination #Fights #cancer #therapy #microrn…
RT @Ermes_Mercury: so proud to unearth new potential targeted therapies against metastatic dissemination #Fights #cancer #therapy #microrn…
RT @Ermes_Mercury: so proud to unearth new potential targeted therapies against metastatic dissemination #Fights #cancer #therapy #microrn…
so proud to unearth new potential targeted therapies against metastatic dissemination #Fights #cancer #therapy #microrna #metastaticcolorectalcancer #metastasis @MolOncology @FEBSnews @Intestinal_Cell @transcriptomes FEBS Press https://t.co/8jqSrSV4JQ https://t.co/eT4m3Mer7N
MicroRNA 483-3p overexpression unleashes invasive growth of metastatic colorectal cancer via ... https://t.co/q5CbTVdP4M