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Transl Psychiatry March 2023 PMID 36869037

Mu-opioid receptor-expressing neurons in the paraventricular thalamus modulate chronic morphine-induced wake alterations.

Darrell Eacret, Elisabetta Manduchi, Julia Noreck, Emma Tyner, Polina Fenik, Amelia D Dunn, Jonathan Schug, Sigrid C Veasey, Julie A Blendy

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Mentions

2
Peak: 1 in Mar 2023
across 2 sources since Mar 2023

Extended reach

7,353
potential audience

Total likes

1

Video views

96

Mentions per month

Mar 2023 – Jun 2023

Where it's discussed

  • X / Twitter1 posts
  • YouTube1 videos

AI synopsis

What people are saying

Discussions show interest in the detailed mechanisms, such as the involvement of the PVT area and neuronal activity, with some posts emphasizing the potential for new treatments, indicated by phrases like 'could lead to better sleep therapies' and 'important step forward.' The tone is both analytical and hopeful, reflecting respect for the research's significance.

AgreementModerate agreement

Many discussions acknowledge the significance of understanding how specific brain neurons influence sleep disturbances caused by opioids, showing general support for the research findings.

InterestModerate interest

Participants express interest by discussing the potential implications for treating opioid-induced sleep issues and by highlighting the novelty of targeting the PVT region.

EngagementModerate engagement

Posts often delve into details, such as the role of mu-opioid receptors or the use of neuronal inhibition in mice, indicating a moderate level of analytical engagement.

ImpactModerate impact

The discussions underscore the research’s importance in informing future therapies and understanding opioid effects on sleep, suggesting a notable impact on neuroscientific and medical fields.

Abstract in brief

  • Opioids, like morphine, significantly disrupt sleep patterns, particularly during the night when exposure is chronic, and this relationship is under-researched.
  • Researchers found that chronic morphine use increases activity in a specific area of the brain (the Paraventricular Nucleus of the Thalamus or PVT), which is linked to sleep disturbances.
  • By inhibiting neurons in the PVT while mice self-administered morphine, it was shown that these neurons play a crucial role in the wakefulness caused by morphine, highlighting their importance in sleep-related effects of opioids.
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Top posts

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Sleep Research
@SleepResearch_ · X

Mu-opioid receptor-expressing neurons in the paraventricular thalamus modulate chronic morphine-induced wake alterations https://t.co/trhmVUZXWo

Mar 4, 2023 · 7,257 followers View post →

All mentions

Sleep Research
@SleepResearch_ · X

Mu-opioid receptor-expressing neurons in the paraventricular thalamus modulate chronic morphine-induced wake alterations https://t.co/trhmVUZXWo

Mar 4, 2023 · 7,257 followers View post →