Cardiovasc Diabetol March 2023 PMID 36870961

Maternal obesity and gestational diabetes reprogram the methylome of offspring beyond birth by inducing epigenetic signatures in metabolic and developmental pathways.

Juan José Alba-Linares, Raúl F Pérez, Juan Ramón Tejedor, David Bastante-Rodríguez, Francisco Ponce, Nuria García Carbonell, Rafael Gómez Zafra, Agustín F Fernández, Mario F Fraga, Empar Lurbe

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Peak: 19 in Mar 2023

across 5 sources since Mar 2023

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126,111

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Mar 2023 – Jul 2024

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What people are saying

The social discussions about the publication highlight a strong recognition of its relevance, especially through phrases like 'epigenetic changes' and 'impact on metabolism,' demonstrating both scientific interest and concern for health outcomes. The tone varies from technical references to broader implications, showing a balanced engagement with the study's significance.

AgreementModerate agreement

The discussions mostly acknowledge the significance of the findings, with many posts emphasizing the potential health implications for offspring due to maternal obesity and gestational diabetes.

InterestHigh interest

The discussions demonstrate high interest, especially with mentions of epigenetic changes, developmental pathways, and potential health consequences, indicating a curiosity about both the biological mechanisms and societal relevance.

EngagementModerate engagement

Posts reflect some degree of deep engagement by referencing specific biological processes such as DNA methylation and metabolic pathways, though some are more general in tone.

ImpactModerate impact

While some discussions suggest the findings could influence future research or public health policies, many posts focus on the biological and health aspects, indicating perceived moderate impact.

Abstract in brief

Obesity and gestational diabetes in mothers significantly increase the risk of cardiometabolic diseases in their children, potentially explained by epigenetic changes in DNA methylation.
This study analyzed DNA methylation patterns in blood samples from 26 children born to mothers with obesity or gestational diabetes, compared to 13 healthy controls, over their first year of life.
Findings revealed notable DNA methylation changes during early development, with specific biomarkers identifying children at risk, indicating impacts on genes linked to fatty acid metabolism and energy production.

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All mentions

Impact of Maternal Obesity and Gestational Diabetes on Offspring Methylation

Maternal obesity and gestational diabetes significantly influence DNA methylation patterns in offspring, potentially affecting their metabolic and developmental health beyond birth. This study analyzes early epigenetic…

Social RTCL TV · Jun 17, 2023 8 views

Epigenetics Lab Asturias

@EpilabAsturias · X

Jul 16, 2024 · 1 like · 359 followers View post →

LRL2017

@lrl2017_rl · X

RT @fundiabetes: #Datos

Sep 6, 2023 · 1 share · 101 followers View post →

Fundación para la Salud Novo Nordisk España

@funsaludnn · X

#Datos

Sep 4, 2023 · 1 like · 1 share · 20,973 followers View post →

Pere Joan Sala

@Fradbius · X

Els fills de dones amb obesitat o diabetis durant l'embaràs poden desenvolupar alteracions epigenètiques q els predisposarien a patir malalties com la diabetis, l'obesitat i problemes cardiovasculars. https://t.co/OVOXlVdyzU

May 26, 2023 · 249 followers View post →

Sophie Duméry Vive l'école !

@SophDum · X

#Diabète de la #grossesse et #obésité maternelle ne sont pas favorables au bébé. Des modifications épigénétiques subséquentes affectent son métabolisme énergétique mitochondrial, celui des acides gras et son développement post-natal. Ollé !

May 15, 2023 · 1,295 followers View post →

Bertrand Neveux

@NeveuxBertrand · X

#Obésité et #diabète pendant la #grossesse... des conséquences deramatiques sur la santé de nos enfants https://t.co/j6GNvcmPTR https://t.co/ZY8mizIP0N

May 15, 2023 · 233 followers View post →

Medical Xpress

@physorg_health · X

#Obesity and diabetes in pregnancy: Consequences in offspring https://t.co/ut7fe2EO0E https://t.co/K9r1NpmCBc

May 12, 2023 · 7,106 followers View post →

CINN

@NanoCINN · X

RT @EpilabAsturias: 1/9

Mar 22, 2023 · 3 shares · 1,247 followers View post →

Victoria Alvarez Martinez

@VIctori25068952 · X

RT @EpilabAsturias: 1/9

Mar 20, 2023 · 3 shares · 172 followers View post →

FINBA

@FINBAsturias · X

RT @EpilabAsturias: 1/9

Mar 20, 2023 · 3 shares · 2,216 followers View post →

Epigenetics Lab Asturias

@EpilabAsturias · X

1/9

Mar 20, 2023 · 8 likes · 3 shares · 359 followers View post →

Jose Hernandez

@Pharma_Mty · X

RT @BioMedCentral: A study published in Cardiovascular Diabetology discusses how maternal obesity and gestational diabetes can impact DNA m…

Mar 10, 2023 · 1 share · 195 followers View post →

BMC

@BioMedCentral · X

Mar 10, 2023 · 3 likes · 1 share · 75,405 followers View post →

Real Academia de Medicina y Cirugía de Valladolid

@RealCirugia · X