Nat Commun March 2023 PMID 36871014

Loss of p53 activates thyroid hormone via type 2 deiodinase and enhances DNA damage.

Annarita Nappi, Caterina Miro, Antonio Pezone, Alfonso Tramontano, Emery Di Cicco, Serena Sagliocchi, Annunziata Gaetana Cicatiello, Melania Murolo, Sepehr Torabinejad, Elena Abbotto, Giuseppina Caiazzo, Maddalena Raia, Mariano Stornaiuolo, Dario Antonini, Gabriella Fabbrocini

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Peak: 5 in Mar 2023

across 2 sources since Mar 2023

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The discussions demonstrate interest in both the biological mechanisms, such as the role of p53 and D2, and the wider scientific implications, evidenced by comments highlighting reproducibility and open science, indicating an overall positive and engaged reception.

AgreementModerate agreement

Some discussions acknowledge the significance of the research and appreciate the emphasis on reproducibility, showing moderate support for the findings.

InterestModerate interest

Comments reflect curiosity about the biological mechanisms and potential therapeutic implications, indicating a moderate level of interest.

EngagementModerate engagement

Posts include references to scientific details like D2 and p53, and mention open science practices, suggesting active and meaningful engagement.

ImpactModerate impact

The discussion hints at potential impacts on cancer treatment strategies and research practices, implying a recognition of the study's importance.

Abstract in brief

Type 2 Deiodinase (D2) is crucial for increasing thyroid hormone (TH) levels during advanced cancer progression, but its regulation is not well understood.
The tumor suppressor p53 suppresses D2 expression, which reduces the availability of THs; loss of p53 leads to increased D2 and TH levels, enhancing tumor cell growth and survival.
Eliminating D2 in living organisms slows down cancer progression, indicating that targeting THs could be an effective strategy for treating cancers with p53 mutations.

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All mentions

p53 Loss Activates Thyroid Hormones and Promotes DNA Damage in Cancer

Loss of p53 activates thyroid hormone production via type 2 deiodinase, enhancing DNA damage and tumor progression, highlighting potential therapeutic targets for cancers with p53 mutations.

STEM RTCL TV · Jun 15, 2023 71 views

OpenSci Talk

@OpenSciTalk · X

RT @RobotRrid: RRIDs were included in the Nature Communications paper "Loss of p53 activates thyroid hormone via type 2 d…" (https://t.co/Z…

Mar 9, 2023 · 1 share · 4,095 followers View post →

RRID Robot

@RobotRrid · X

Mar 9, 2023 · 1 share · 161 followers View post →

LiteratureFeed

@LiteratureFeed · X

NER: Loss of p53 activates thyroid hormone via type 2 deiodinase and enhances DNA damage https://t.co/FHXfvR1Prk

Mar 7, 2023 · 156 followers View post →

DNA Repair Articles

@DNA_Repair_JC · X

Loss of p53 activates thyroid hormone via type 2 deiodinase and enhances DNA damage. https://t.co/2GkpqnNLIf

Mar 6, 2023 · 1,150 followers View post →

DTHSTR

@CDADeathStar · X

Loss of p53 activates thyroid hormone via type 2 deiodinase and enhances DNA damage null https://t.co/iSLH2my17m #DTHSTR

Mar 4, 2023 · 113 followers View post →