Adv Sci (Weinh) May 2023 PMID 36876644

Raddeanin A Enhances Mitochondrial DNA-cGAS/STING Axis-Mediated Antitumor Immunity by Targeting Transactive Responsive DNA-Binding Protein 43.

Mingxiao Yin, Jingwen Dong, Cuicui Sun, Xiaojia Liu, Zhirui Liu, Lu Liu, Zean Kuang, Na Zhang, Dian Xiao, Xinbo Zhou, Hongbin Deng

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What people are saying

The discussions show strong support and curiosity about how Raddeanin A modulates immune responses, with mentions of its targeting of TDP43 and activation of the cGAS-STING pathway, emphasizing its potential to boost cancer therapies. Users use technical terms and optimistic language like 'breakthrough' and 'promising,' reflecting both engagement and perceived impact.

AgreementModerate agreement

Most discussions recognize the significance of Raddeanin A in enhancing tumor immunity through the cGAS-STING pathway, showing general support for the paper's findings.

InterestHigh interest

Comments reflect high interest, with users eager to explore how Raddeanin A could be used in cancer treatments and its mechanism involving TDP43 and mitochondrial DNA leakage.

EngagementModerate engagement

Participants actively analyze the implications and mechanisms, referencing specific molecular pathways and potential combined therapies, indicating thoughtful engagement.

ImpactModerate impact

The social discussions suggest that the publication could influence future research directions in cancer immunotherapy and drug development, highlighting its potential impact.

Abstract in brief

Raddeanin A (RA), a compound from Anemone raddeana, acts as an inducer of immunogenic cell death (ICD) by promoting the release of tumor-damaging signals like high-mobility group box 1, which enhances immune responses against tumors.
RA targets the protein TDP43, causing it to relocate to the mitochondria, which leads to mitochondrial DNA leakage and activation of the cGAS-STING pathway, crucial for stimulating immune signaling and T cell activation.
When combined with immune checkpoint therapy (anti-PD-1), RA significantly improves the immune system's ability to fight tumors in animal models, suggesting its potential to boost cancer immunotherapy effectiveness.]

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Raddeanin A Boosts Mitochondrial DNA cGAS/STING Antitumor Immunity

Raddeanin A induces immunogenic cell death by promoting mitochondrial DNA leakage, activating the cGAS-STING pathway, and enhancing immune responses against tumors. It targets TDP43, improving the efficacy of immune…

STEM RTCL TV · Aug 24, 2023 44 views

DNA-binding drugs

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Raddeanin A Enhances Mitochondrial DNA-cGAS/STING Axis-Mediated Antitumor Immunity by Targeting Transactive Responsive DNA-Binding Protein 43 https://t.co/XhtHxNr4au

Mar 6, 2023 · 670 followers View post →