Cell Discov March 2023 PMID 36878933

CD36 cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor.

Gui-Qi Zhu, Zheng Tang, Run Huang, Wei-Feng Qu, Yuan Fang, Rui Yang, Chen-Yang Tao, Jun Gao, Xiao-Ling Wu, Hai-Xiang Sun, Yu-Fu Zhou, Shu-Shu Song, Zhen-Bin Ding, Zhi Dai, Jian Zhou

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Mentions

Peak: 8 in Mar 2023

across 2 sources since Mar 2023

Extended reach

7,797

potential audience

Total likes

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Mentions per month

Mar 2023 – Jul 2023

Where it's discussed

X / Twitter9 posts
YouTube1 videos

AI synopsis

What people are saying

The overall tone reflects strong interest and moderate agreement, with posts highlighting key findings such as the role of CD36+ fibroblasts in immune suppression and the potential for improved therapies, exemplified by phrases like 'targeting CD36 could enhance treatment' and discussions about combining therapies. The use of technical terms and focus on implications show engaged and invested commentary, though it remains cautious about immediate impact.

AgreementModerate agreement

Most discussions acknowledge the significance of the study, reflecting a general consensus on its importance for understanding tumor microenvironments.

InterestHigh interest

Posts demonstrate high curiosity, especially regarding potential therapeutic implications such as combining targeting CD36 with immunotherapy.

EngagementModerate engagement

Several comments delve into the mechanisms and future research directions, indicating moderate to deep engagement.

ImpactModerate impact

The discussions hint at an expectation that this research could influence future treatments and research, although not explicitly stating revolutionary impact.

Abstract in brief

This study focuses on a type of cancer called hepatocellular carcinoma (HCC), which is resistant to immunotherapy and involves many different cell types, including cancer-associated fibroblasts (CAFs).
Researchers identified a specific CAF subset marked by CD36 that has high lipid metabolism and produces a molecule called MIF, which promotes immune suppression by attracting immune cells that inhibit attack on the tumor.
Targeting CD36, especially in combination with immunotherapy like anti-PD1, can potentially improve treatment outcomes by reducing immune suppression and enhancing T cell responses against HCC.]

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All mentions

CD36+ Fibroblasts Create Immunosuppressive Environment in Hepatocellular Carcinoma

This study highlights the role of CD36-expressing cancer-associated fibroblasts in hepatocellular carcinoma by secreting MIF, which promotes immune suppression. Targeting CD36 could improve immunotherapy effectiveness.

Social RTCL TV · Jul 4, 2023 36 views

Cell Stress & Immunity (CSI) Lab

@AbhishekDGarg · X

CD36+ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor https://t.co/tpEjqCoIdV

Jul 25, 2023 · 2 likes · 671 followers View post →

Jaxon Christie

@ParabolSpirit · X

RT @PubTrend: Trending on PubMed: CD36+ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcin…

Mar 17, 2023 · 2 shares · 589 followers View post →

Fábio Fonseca

@FbioFon84085623 · X

RT @PubTrend: Trending on PubMed: CD36+ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcin…

Mar 17, 2023 · 2 shares · 580 followers View post →

PubMed Trending

@PubTrend · X

Mar 17, 2023 · 2 likes · 2 shares · 5,154 followers View post →

the paper link

@the_paper_link · X

Trend top+1: Zhu GQ, ..., Shi YH (Cell Discov) __CD36(+) cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor__ https://t.co/enkbNbBLlI

Mar 9, 2023 · 137 followers View post →

MD_PhD in Japan

@japan_phd · X

がん免疫療法（PD-1阻害剤）とCD36阻害剤を一緒に投与すると、肝癌（HCC）で治療効果増大か⁉️ https://t.co/zmnSnZpNEl

Mar 8, 2023 · 295 followers View post →

Endocryne Papers

@Endocryne_reads · X

CD36+ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhi... https://t.co/v9MBub1c2G

Mar 8, 2023 · 21 followers View post →

L2P Research Labs

@l2presearch · X

RT @l2presearch: CD36+ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion…

Mar 6, 2023 · 1 share · 149 followers View post →