Am J Psychiatry May 2023 PMID 36891640

Risk of Experiencing an Overdose Event for Patients Undergoing Treatment With Medication for Opioid Use Disorder.

Laura Brandt, Mei-Chen Hu, Ying Liu, Felipe Castillo, Gabriel J Odom, Raymond R Balise, Daniel J Feaster, Edward V Nunes, Sean X Luo

Mentions

15
Peak: 6 in May 2023
across 3 sources since Mar 2023

Extended reach

96,901
potential audience

Total likes

11

Video views

99

Mentions per month

Mar 2023 – May 2023

Where it's discussed

  • X / Twitter11 posts
  • YouTube2 videos
  • Reddit2 posts

AI synopsis

What people are saying

Discussions focus on key aspects such as higher overdose risks associated with medication discontinuation and benzodiazepine use, with posts emphasizing the importance of medication adherence and informing treatment strategies; the tone and detailed references to hazard ratios indicate a serious and analytical engagement with the research's implications.

AgreementModerate agreement

Most discussions agree that medication adherence and baseline benzodiazepine use are significant factors influencing overdose risk, reflected in statements like 'risk is elevated among those who fail to initiate or discontinue medication.'

InterestHigh interest

The posts demonstrate high interest, with detailed mentions of clinical trial data, hazard ratios, and specific factors affecting overdose risk, indicating active engagement with the research.

EngagementHigh engagement

Several discussions reference specific statistics, such as hazard ratios and trial sources, showing deep engagement with the methodological and clinical implications.

ImpactModerate impact

The findings are seen as impactful, highlighting issues like early overdose risks and medication management, though there’s less emphasis on policy change or broader societal implications.

Abstract in brief

  • The study investigates the risk of overdose among patients undergoing medication for opioid use disorder (MOUD), finding that the overall risk over 24 weeks varies depending on medication adherence and patient characteristics.
  • Patients who never started their assigned medication or discontinued early had higher overdose risks, especially if they used benzodiazepines at baseline.
  • Using survival analysis, the researchers found no significant difference in overdose risk based solely on medication type (methadone, naltrexone, buprenorphine), but adherence and baseline substance use played crucial roles in overdose likelihood.]

Top posts

Most liked on X and Bluesky
NIDAnews
@NIDAnews · X

Apr 17, 2023 · 6 likes · 5 shares · 53,197 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

Data from Laura Brandt @CityCollegeNY and colleagues drawn from three clinical trials indicate that patients undergoing medication treatment for #opioid use disorder have a non-negligible risk of overdose events in the first 24 weeks. https://t.co/yG4fVKgaED https://t.co/Q8VIS2rAKV

Mar 9, 2023 · 3 likes · 2 shares · 11,606 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

Risk of Experiencing an Overdose Event for Patients Undergoing Treatment With Medication for Opioid Use Disorder https://t.co/dnDdzUl24q

May 24, 2023 · 1 like · 11,606 followers View post →
Xavier Castells
@xccastells · X

Among patients with opioid use disorder under treatment, the risk of overdose events is elevated among those who: 1) fail to initiate or discontinue medication, 2) report benzodiazepine use and 2) receive naltrexone instead of opiod maintenance. https://t.co/MwLzP6IGu4

May 2, 2023 · 1 like · 418 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

AJP Deputy Editor Danny Pine highlights two articles from the May 2023 issue. https://t.co/yvjReUkvBV

May 24, 2023 · 11,606 followers View post →
The College on Problems of Drug Dependence
@CPDDorg · X

RT @NIDAnews:

Apr 17, 2023 · 5 shares · 2,380 followers View post →

All mentions

Journals of The American Psychiatric Association
@APAPubJournals · X

AJP Deputy Editor Danny Pine highlights two articles from the May 2023 issue. https://t.co/yvjReUkvBV

May 24, 2023 · 11,606 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

Risk of Experiencing an Overdose Event for Patients Undergoing Treatment With Medication for Opioid Use Disorder https://t.co/dnDdzUl24q

May 24, 2023 · 1 like · 11,606 followers View post →
P
@psychopharmacol · X

Among patients with OUD seeking treatment, the risk of overdose over the next 24 weeks is elevated among those who fail to initiate (HR=6.64; 2.12-19.54) or discontinue medication (4.04; 1.54-10.65) and those who use BZDs at baseline (3.36; 1.76-6.42) https://t.co/tUBcdEYBSm

May 4, 2023 · 569 followers View post →
Xavier Castells
@xccastells · X

Among patients with opioid use disorder under treatment, the risk of overdose events is elevated among those who: 1) fail to initiate or discontinue medication, 2) report benzodiazepine use and 2) receive naltrexone instead of opiod maintenance. https://t.co/MwLzP6IGu4

May 2, 2023 · 1 like · 418 followers View post →
Shahrdad Lotfipour, Ph.D.
@shlotfipour · X

RT @NIDAnews:

Apr 17, 2023 · 5 shares · 2,069 followers View post →
UCI BTC
@BtcUci · X

RT @NIDAnews:

Apr 17, 2023 · 5 shares · 378 followers View post →
The College on Problems of Drug Dependence
@CPDDorg · X

RT @NIDAnews:

Apr 17, 2023 · 5 shares · 2,380 followers View post →
Pub Health Monitor
@monitor_PH · X

RT @NIDAnews:

Apr 17, 2023 · 5 shares · 1,816 followers View post →
NIDAnews
@NIDAnews · X

Apr 17, 2023 · 6 likes · 5 shares · 53,197 followers View post →
Austin Lam
@austinaldenlam · X

"Among patients with opioid use disorder seeking medication treatment, the risk of overdose events over the next 24 weeks is elevated among those who fail to initiate or discontinue medication and those who report benzodiazepine use at baseline." https://t.co/nAm2IvmP6w

Mar 16, 2023 · 1,084 followers View post →
Journals of The American Psychiatric Association
@APAPubJournals · X

Data from Laura Brandt @CityCollegeNY and colleagues drawn from three clinical trials indicate that patients undergoing medication treatment for #opioid use disorder have a non-negligible risk of overdose events in the first 24 weeks. https://t.co/yG4fVKgaED https://t.co/Q8VIS2rAKV

Mar 9, 2023 · 3 likes · 2 shares · 11,606 followers View post →
[Article] Risk of Experiencing an Overdose Event for Patients ...
Reddit

AJP **Published Online:**9 Mar 2023 DOI: https://doi.org/10.1176/appi.ajp.20220312 URL…

Mar 13, 2023 View →
[Artículo] Riesgo de experimentar una sobredosis para pacientes en ...
Reddit

AJP Publicado en línea: 9 de marzo de 2023 DOI: https://doi.org/10.1176/appi.ajp.20220312 URL…

Mar 13, 2023 View →