In situ wet pharmaceutical granulation captured using synchrotron radiation based dynamic micro-CT.

Abstract in brief

• Synchrotron radiation based dynamic microCT is a powerful, nondestructive imaging technique that captures real-time changes in the microstructure of wet pharmaceutical granulation, which occurs very rapidly (within seconds).
• The study used lactose monohydrate (LMH) as an example to demonstrate how dynamic CT can analyze the internal microstructure during wet granulation, revealing details like granule consolidation, porosity changes, and the effects of aggregates.
• This advanced imaging approach overcomes limitations of traditional lab-based CT, enabling detailed, quantitative insights into early stages of wet granulation, which previously could only be studied with less detailed 2D or ex situ methods.]