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Multiple discussions highlight key findings from the publication, such as the reduction in tau phosphorylation and amyloid-ß levels due to suvorexant use. Phrases like 'this could be really helpful for Alzheimer's' and 'interesting proof of concept' reflect the optimistic tone of the discussions, showing how the language used helps convey excitement and curiosity about the implications of these findings.
Most discussions indicate strong support for the findings and potential applications of suvorexant.
The topic has generated significant curiosity and relevance among participants, especially regarding Alzheimer's prevention.
While many users express interest, fewer delve deeply into the methodologies discussed in the publication.
Many believe the research could significantly influence future treatments for Alzheimer's and sleep aids.
Sleeping pill found to reduce levels of Alzheimer's proteins @WUSTLmedschool @TheNewANA1 https://t.co/jR9HUpwblA https://t.co/1YJRPc1NAz
スボレキサントが脳脊髄液中のリン酸化タウとアミロイドβを抑制する。 まだ参考程度の話だけど、面白いデータだなぁ。 後続データを待つ。 https://t.co/NxmLpD1pRL 原著 https://t.co/uCtBymyxa4
Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS - will we see suvorexant used in Alzheimer's? https://t.co/sWPypXiC15
二重orexin受容体拮抗薬Suvorexant(ベルソムラ)は認知機能正常ヒトCSFのT181リン酸化とAβを睡眠時間、睡眠相と無関係に低下させる 20mgを眠前投与しCSFを連続的に採取した例に顕著 OXR1のMAPK,ERK1,ERK2リン酸化阻止によりtauリン酸化を阻止する？ #orexin #AD #papers https://t.co/OVSWk4JgX5
Suvorexant acutely decreases tau phosphorylation and Aβ in the human CNS https://t.co/qj2XaIbmGI
This week's news highlights significant advancements in cancer treatment and neurological research, including the promising efficacy of ONC201 for H3K27M-mutant diffuse midline gliomas, which disrupts metabolic and…
@mann_co_high 最近は、AIがすぐ論文を見つけてくれますなぁ スボレキサントがタウ蛋白リン酸化の阻害を介して認知症を予防するかもという論文はこちら https://t.co/HPzpkYMkUQ
RT @thmonk_pf: 二重orexin受容体拮抗薬Suvorexant(ベルソムラ)は認知機能正常ヒトCSFのT181リン酸化とAβを睡眠時間、睡眠相と無関係に低下させる 20mgを眠前投与しCSFを連続的に採取した例に顕著 OXR1のMAPK,ERK1,ERK2リ…
RT @thmonk_pf: 二重orexin受容体拮抗薬Suvorexant(ベルソムラ)は認知機能正常ヒトCSFのT181リン酸化とAβを睡眠時間、睡眠相と無関係に低下させる 20mgを眠前投与しCSFを連続的に採取した例に顕著 OXR1のMAPK,ERK1,ERK2リ…
Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS - Lucey - 2023 - Annals of Neurology - Wiley Online Library https://t.co/ImfSu1XILd
There may be a way to help clear amyloid-β levels and amyloid plaques Needs more study but if it works this could be really helpful for Alzheimer's and people in general. pubmed.ncbi.nlm.nih.gov/36897120/
https://t.co/b4wHg4DvTV
I found this a bit interesting, I am not certain why I did not come across this before? Suvorexant acutely decreases tau phosphorylation and Aβ in the human CNS. "Suvorexant is approved by the Food and Drug Administration to treatment insomnia and may have potential as a
I found this a bit interesting, I am not certain why I did not come across this before? Suvorexant acutely decreases tau phosphorylation and Aβ in the human CNS.
Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS https://t.co/8RosaAKlX3 https://t.co/25QzdhfBTX
small RCT: suvorexant 20 mg, a dual orexin r. antag., ↓ the CSF ratio of phosphorylated-tau-threonine-181 to unphosphorylated ~10% to 15% vs. placebo. Phosphorylation at tau-serine-202 and -217 were not ↓. Suvorexant ↓ amyloid-β ~10% to 20% vs. placebo https://t.co/MO5LHZklPx
RT @AMahajanMD: Suvorexant, a dual orexin receptor antagonist ✅acutely decreased tau phosphorylation at T181 and Aβ levels in human CSF ✅…
RT @AMahajanMD: Suvorexant, a dual orexin receptor antagonist ✅acutely decreased tau phosphorylation at T181 and Aβ levels in human CSF ✅…
https://onlinelibrary.wiley.com/doi/10.1002/ana.26641
Suvorexant, a dual orexin receptor antagonist ✅acutely decreased tau phosphorylation at T181 and Aβ levels in human CSF ✅Cognitive unimpaired before and after ✅ No increase in total sleep time, efficiency, time in REM or non-REM sleep, wrt to placebo https://t.co/JJWbWcVkpV
@e_mc2_naruko 可能性を示唆する報告がありますね⇩ https://t.co/woIL9dT511
https://t.co/ODeCXUYHeE
RT @mak_mike: Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS - will we see suvorexant used in Alzheimer's? https…
RT @mak_mike: Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS - will we see suvorexant used in Alzheimer's? https…
RT @mak_mike: Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS - will we see suvorexant used in Alzheimer's? https…
POSSIBLE ALZHEIMER’S SUPPRESSANT
RT @mak_mike: Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS - will we see suvorexant used in Alzheimer's? https…
Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS - will we see suvorexant used in Alzheimer's? https://t.co/sWPypXiC15
RT @GayatriDevi: Why is it so hard to get a good night's sleep when we were born experts at it?! Sadly, most sleeping aids have side effect…
Then @BrendanLucey_MD and colleagures demonstrated that the orexin antagonist sleep drug suvorexant can acutely lower CSF amyloid-beta peptide and p-tau levels in humans, paving the way for new AD preventative strategies. https://t.co/pUczb4hQQN
https://t.co/eJrpiA5iJi
@natsupikkk https://t.co/HKrY317nwq https://t.co/nZVRpg5rmJ
Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS https://t.co/g7v06ct2jG
Why is it so hard to get a good night's sleep when we were born experts at it?! Sadly, most sleeping aids have side effects. A new class of drugs, the orexin antagonists, may help us sleep better AND be good for our brains. https://t.co/BId7tXs5r2
https://t.co/BD79zrp2zl
不眠症治療薬 vs アルツハイマー https://t.co/CDS1mcT6jr 高用量のsuvorexantにより脳脊髄液中のAβおよびp-tauの量が10～20％ほど減少した。これらの指標は一日中低下したままだったというのも面白い。 https://t.co/RB3DB8j4Oe
RT @shwan_hameed:
RT @shwan_hameed:
RT @shwan_hameed:
RT @MRSleepDep: For persons suffering from insomnia and are worried about Alzheimer's , this may be very interesting..... https://t.co/rF8d…
https://t.co/YVP1gIuNCF
For persons suffering from insomnia and are worried about Alzheimer's , this may be very interesting..... https://t.co/rF8dBM8ix2
Alzheimer's finding: Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS https://t.co/mQFBKZNlSK
Placebo (n=13) controlled trial on the effects of the dual orexin antagonist suvorexant 10 mg (n=13) or 20 mg (n=12) on CSF amyloid-β, tau, and phospho-tau: It's interesting that even a single dose led to detectable differences in phosphorylation & Aβ. https://t.co/x99XmfdPa3
Insomnia Drug (orexin antagonist) May Hold Promise for Alzheimer’s Prevention: “Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS” #sleep #dementia #Alzheimer #psychiatry https://t.co/k5rzYrNpER
https://t.co/EHx74KaMnM
@Tamara7063 Very interesting. Here's a quick tip bit on it.https://t.co/gZbcpBP4Z5
RT @medical_xpress: Sleeping pill found to reduce levels of Alzheimer's proteins @WUSTLmedschool @TheNewANA1 https://t.co/jR9HUpwblA https:…
I hope this paper gets a lot of attention. Sleeping better may be a key to reducing Alzheimer’s risk and the right type of sleep aid could make a big difference. https://t.co/33ng7Fji9A
大元 https://t.co/wZn5Nwc0H8
@ichiipsy 睡眠薬は長期使用によって認知症が進行する恐れがあるとも言われるけど、睡眠不足が続くことによっても認知症が進行する恐れがあり、睡眠薬をとにかく拒絶するのではなく患者様の病状に合わせて治療することが重要なのかもしれない。 https://t.co/mqFJFPGK9f
睡眠薬は長期使用によって認知症が進行する恐れがあるとも言われるけど、睡眠不足が続くことによっても認知症が進行する恐れがあり、睡眠薬をとにかく拒絶するのではなく患者様の病状に合わせて治療することが重要なのかもしれない。 https://t.co/mqFJFPGK9f
高リン酸化タウ10~15%）しました。この結果は、睡眠薬がアルツハイマー病の進行を遅らせたり止めたりする可能性を示唆していますが、さらに多くの研究が必要です。https://t.co/V7aCYBGRtd
small RCT: suvorexant 20 mg acutely decreased tau phosphorylation (~10% to 15%) and amyloid-β concentrations (~10% to 20%) in the CNS vs. placebo in cognitively unimpaired adults https://t.co/shFB5hkx5B
Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS https://t.co/Qs0jobbLue
RT @NeuroscienceNew: “Suvorexant acutely decreases tau phosphorylation and Aβ in the human CNS” by Brendan Lucey et al. Annals of Neurology…
Interesting proof of concept article. Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS - Lucey - Annals of Neurology - Wiley Online Library via @BrendanLucey_MD https://t.co/HFJRNXEPoN
Suvorexant decreases Amyloid-β and Tau 181 but not 217 in middle aged cognitively unimpaired people at about 5 hours post administration. https://t.co/F9muPvv7sN
Suvorexant Acutely Decreases Tau Phosphorylation and Aβ in the Human CNS
RT @NeuroscienceNew: “Suvorexant acutely decreases tau phosphorylation and Aβ in the human CNS” by Brendan Lucey et al. Annals of Neurology…
RT @NeuroscienceNew: “Suvorexant acutely decreases tau phosphorylation and Aβ in the human CNS” by Brendan Lucey et al. Annals of Neurology…
“Suvorexant acutely decreases tau phosphorylation and Aβ in the human CNS” by Brendan Lucey et al. Annals of Neurology https://t.co/pYNTzoe6AL
RT @medical_xpress: Sleeping pill found to reduce levels of Alzheimer's proteins @WUSTLmedschool @TheNewANA1 https://t.co/jR9HUpwblA https:…
RT @medical_xpress: Sleeping pill found to reduce levels of Alzheimer's proteins @WUSTLmedschool @TheNewANA1 https://t.co/jR9HUpwblA https:…
RT @medical_xpress: Sleeping pill found to reduce levels of Alzheimer's proteins @WUSTLmedschool @TheNewANA1 https://t.co/jR9HUpwblA https:…
RT @medical_xpress: Sleeping pill found to reduce levels of Alzheimer's proteins @WUSTLmedschool @TheNewANA1 https://t.co/jR9HUpwblA https:…
RT @medical_xpress: Sleeping pill found to reduce levels of Alzheimer's proteins @WUSTLmedschool @TheNewANA1 https://t.co/jR9HUpwblA https:…
RT @medical_xpress: Sleeping pill found to reduce levels of Alzheimer's proteins @WUSTLmedschool @TheNewANA1 https://t.co/jR9HUpwblA https:…
RT @medical_xpress: Sleeping pill found to reduce levels of Alzheimer's proteins @WUSTLmedschool @TheNewANA1 https://t.co/jR9HUpwblA https:…
RT @medical_xpress: Sleeping pill found to reduce levels of Alzheimer's proteins @WUSTLmedschool @TheNewANA1 https://t.co/jR9HUpwblA https:…
RT @medical_xpress: Sleeping pill found to reduce levels of Alzheimer's proteins @WUSTLmedschool @TheNewANA1 https://t.co/jR9HUpwblA https:…
RT @medical_xpress: Sleeping pill found to reduce levels of Alzheimer's proteins @WUSTLmedschool @TheNewANA1 https://t.co/jR9HUpwblA https:…
Sleeping pill found to reduce levels of Alzheimer's proteins @WUSTLmedschool @TheNewANA1 https://t.co/jR9HUpwblA https://t.co/1YJRPc1NAz
RT @lostphysicianYB: スボレキサントが脳脊髄液中のリン酸化タウとアミロイドβを抑制する。 まだ参考程度の話だけど、面白いデータだなぁ。 後続データを待つ。 https://t.co/NxmLpD1pRL 原著 https://t.co/uCtBymyx…
スボレキサントが脳脊髄液中のリン酸化タウとアミロイドβを抑制する。 まだ参考程度の話だけど、面白いデータだなぁ。 後続データを待つ。 https://t.co/NxmLpD1pRL 原著 https://t.co/uCtBymyxa4
RT @NatRevNeurol: Suvorexant acutely decreases tau phosphorylation and Aβ in the human CNS https://t.co/qj2XaIbmGI
Suvorexant acutely decreases tau phosphorylation and Aβ in the human CNS - Lucey - Annals of Neurology - Wiley Online Library https://t.co/pqurbwpwq3
RT @thmonk_pf: 二重orexin受容体拮抗薬Suvorexant(ベルソムラ)は認知機能正常ヒトCSFのT181リン酸化とAβを睡眠時間、睡眠相と無関係に低下させる 20mgを眠前投与しCSFを連続的に採取した例に顕著 OXR1のMAPK,ERK1,ERK2リ…
RT @thmonk_pf: 二重orexin受容体拮抗薬Suvorexant(ベルソムラ)は認知機能正常ヒトCSFのT181リン酸化とAβを睡眠時間、睡眠相と無関係に低下させる 20mgを眠前投与しCSFを連続的に採取した例に顕著 OXR1のMAPK,ERK1,ERK2リ…
RT @NatRevNeurol: Suvorexant acutely decreases tau phosphorylation and Aβ in the human CNS https://t.co/qj2XaIbmGI
二重orexin受容体拮抗薬Suvorexant(ベルソムラ)は認知機能正常ヒトCSFのT181リン酸化とAβを睡眠時間、睡眠相と無関係に低下させる 20mgを眠前投与しCSFを連続的に採取した例に顕著 OXR1のMAPK,ERK1,ERK2リン酸化阻止によりtauリン酸化を阻止する？ #orexin #AD #papers https://t.co/OVSWk4JgX5
Suvorexant acutely decreases tau phosphorylation and Aβ in the human CNS https://t.co/qj2XaIbmGI