Nat Commun March 2023 PMID 36898988

The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and motile forms in Plasmodium berghei.

Ravish Rashpa, Natacha Klages, Domitille Schvartz, Carla Pasquarello, Mathieu Brochet

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Mentions

Peak: 6 in Mar 2023

across 2 sources since Mar 2023

Extended reach

15,219

potential audience

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Mentions per month

Mar 2023 – Jun 2023

Where it's discussed

X / Twitter6 posts
YouTube1 videos

AI synopsis

What people are saying

The discussions largely focus on the importance of the Skp1-Cullin1-FBXO1 complex for parasite development, with phrases like 'crucial for gamete formation' and 'motile forms,' signaling recognition of the research's significance. The tone is mostly factual and emphasizing the biological importance, reflecting curiosity and acknowledgment of potential impacts on malaria biology and treatment.

AgreementModerate agreement

Most posts recognize the importance of the Skp1-Cullin1-FBXO1 complex in malaria parasite biology, indicating general agreement with the significance of the findings.

InterestModerate interest

Discussions show moderate interest, with posts emphasizing the biological role of the complex but not delving deeply into technical details.

EngagementModerate engagement

Users interact by sharing the core message, suggesting a moderate level of engagement, such as retweeting or restating the main points.

ImpactHigh impact

Posts imply that understanding this complex could influence future malaria research and control strategies, highlighting a high perceived impact.

Abstract in brief

Plasmodium parasites, specifically Plasmodium berghei, go through different developmental phases in both humans and mosquitoes, with ubiquitination playing a crucial, yet under-researched, role in their biology.
The study identifies a conserved SCF complex (SKP1/Cullin1/FBXO1) that is vital for processes like cell division and the development of gametes, influencing how the parasites move from one host to another.
Through ubiquitinomic analysis, the research highlights a network of proteins regulated by FBXO1 that are key for the parasite's lifecycle, demonstrating a complex interaction between ubiquitination and phosphorylation that affects the parasite's survival and reproduction in its hosts.

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All mentions

Role of SCF Complex in Plasmodium berghei Lifecycle and Reproduction

The Skp1-Cullin1-FBXO1 complex is essential for gamete formation and motility in Plasmodium berghei. The study highlights the complex's role in parasite development, reproduction, and lifecycle progression, emphasizing…

STEM RTCL TV · Jun 18, 2023 29 views

micropapers

@micro_papers · X

The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and motile forms in Plasmodium berghei https://t.co/loOSUoOCfX

Mar 11, 2023 · 332 followers View post →

Bloodsucking Parasites

@bloodSparasites · X

RT @MalariaPapers: The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and motile forms in Plas…

Mar 11, 2023 · 1 share · 5,089 followers View post →

Malaria Papers

@MalariaPapers · X

The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and motile forms in Plasmodium berghei https://t.co/ZB6McwuE6y

Mar 11, 2023 · 1 like · 1 share · 1,546 followers View post →

Bloodsucking Parasites

@bloodSparasites · X

RT @mosquito_papers: The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and motile forms in Pl…

Mar 11, 2023 · 1 share · 5,089 followers View post →

Centrosome Papers

@CentrosomePub · X

The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and motile forms in Plasmodium berghei https://t.co/tP58ea2cFJ

Mar 11, 2023 · 662 followers View post →

MosquitoPapers

@mosquito_papers · X

The Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and motile forms in Plasmodium berghei https://t.co/vx7iSVlwlC

Mar 11, 2023 · 4 likes · 1 share · 2,465 followers View post →