Ann Intensive Care March 2023 PMID 36906875

Intravenously administered interleukin-7 to reverse lymphopenia in patients with septic shock: a double-blind, randomized, placebo-controlled trial.

Thomas Daix, Armelle Mathonnet, Scott Brakenridge, Pierre-François Dequin, Jean-Paul Mira, Frederique Berbille, Michel Morre, Robin Jeannet, Teresa Blood, Jacqueline Unsinger, Jane Blood, Andrew Walton, Lyle L Moldawer, Richard Hotchkiss, Bruno François

Mentions

5
Peak: 2 in Mar 2023
across 3 sources since Mar 2023

Extended reach

1,960
potential audience

Total likes

1

Video views

35

Mentions per month

Mar 2023 – Jul 2023

Where it's discussed

  • X / Twitter2 posts
  • Blogs2 articles
  • YouTube1 videos

AI synopsis

What people are saying

Discussions about the article are minimal, with some viewers showing mild curiosity regarding the trial's findings, as evidenced by neutral language and a lack of detailed critique or enthusiasm, which points to a moderate overall interest and engagement level without a clear consensus on the study's impact.

AgreementNeither agree nor disagree

The lack of detailed discussion suggests that viewers are neutral or undecided about the study’s findings, with minimal explicit support or disagreement.

InterestModerate interest

Interest appears modest as there are no strong emotional or enthusiastic responses, but some viewers show curiosity about the implications.

EngagementNeutral engagement

The absence of in-depth comments or critical analysis indicates an average level of engagement, possibly viewing the study as informative but not deeply impactful.

ImpactModerate impact

While the study raises important questions about treatment tolerability, the conversations do not strongly emphasize a major shift in clinical practice or public health.

Abstract in brief

  • The study aimed to evaluate the effects of intravenous CYT107, a recombinant human IL-7, in sepsis patients, focusing on its ability to reverse lymphopenia and improve immune function.
  • Twenty-one patients were enrolled, but the trial was halted early due to adverse reactions in some who received IV CYT107, despite observing increased lymphocyte counts similar to intramuscular administration.
  • Ultimately, while IV CYT107 showed effectiveness, it caused transient respiratory distress and is deemed less preferable than intramuscular administration due to better tolerability and pharmacokinetics.

Top posts

Most liked on X and Bluesky
Dataemia
@Dataemia · X

Intravenously administered interleukin-7 to reverse lymphopenia in patients with septic shock: a double-blind, randomized, placebo-controlled trial - https://t.co/e7JMvBwuC9 -

Mar 13, 2023 · 963 followers View post →
Dataemia
@Dataemia · X

Intravenously administered interleukin-7 to reverse lymphopenia in patients with septic shock: a double-blind, randomized, placebo-controlled trial - https://t.co/ji8L6VPcPI -

Mar 12, 2023 · 963 followers View post →

All mentions

Dataemia
@Dataemia · X

Intravenously administered interleukin-7 to reverse lymphopenia in patients with septic shock: a double-blind, randomized, placebo-controlled trial - https://t.co/e7JMvBwuC9 -

Mar 13, 2023 · 963 followers View post →
Dataemia
@Dataemia · X

Intravenously administered interleukin-7 to reverse lymphopenia in patients with septic shock: a double-blind, randomized, placebo-controlled trial - https://t.co/ji8L6VPcPI -

Mar 12, 2023 · 963 followers View post →