Nat Commun March 2023 PMID 36914620

TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport.

John T Canty, Andrew Hensley, Merve Aslan, Amanda Jack, Ahmet Yildiz

Full text PDF Download social card

Mentions

Peak: 14 in Mar 2023

across 2 sources since Mar 2023

Extended reach

37,460

potential audience

Total likes

Video views

Mentions per month

Mar 2023 – Jul 2024

Where it's discussed

X / Twitter18 posts
YouTube1 videos

AI synopsis

What people are saying

The overall tone indicates a balanced interest with recognition of the study’s significance, as seen in posts mentioning how TRAK adaptors control motor recruitment and facilitate transport without causing damage, demonstrating curiosity and appreciation for the findings. Phrases like 'regulate' and 'activate' reflect technical discussions that align with the importance of the research without overly dramatic language.

AgreementModerate agreement

Most discussions acknowledge the importance of the research, indicating general support for its findings, though some remain neutral or analytical rather than strongly supportive.

InterestModerate interest

Participants show moderate curiosity, often highlighting the biological mechanisms without deep technical engagement, but some express enthusiasm about potential implications.

EngagementModerate engagement

Comments reference core concepts like motor regulation and mitochondrial transport, suggesting a decent level of engagement, though few delve into detailed critiques or broader implications.

ImpactModerate impact

The discussions suggest this research is seen as potentially influential in understanding cellular processes, though the tone remains cautiously optimistic rather than revolutionary.

Abstract in brief

The study investigates how mitochondria are transported along microtubules using two motors, kinesin1 and dynein, with Miro1 and TRAK adaptors coordinating their activity.
TRAK adaptors activate dynein-dynactin and enhance kinesin1 movement, with each adaptor guiding mitochondria to move in the direction of kinesin1 and avoiding motor tug-of-war.
The research shows that mitochondrial transport can be halted by calcium-dependent recruitment of the protein syntaphilin, which creates resistive forces, rather than by breaking down the transport machinery itself.]

Read the full abstract

All mentions

TRAK Adaptors Regulate Mitochondrial Transport via Dynein and Kinesin Activation

This study explores how mitochondria are transported along microtubules, focusing on the role of TRAK adaptors in activating dynein and kinesin motors. It highlights the mechanisms guiding mitochondrial movement and the…

STEM RTCL TV · Jun 16, 2023 15 views

AngryPhDstudent❗️❗️❗️

@ONNESHA092 · X

RT @Madam_Mito: TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport | Nature Communicati…

Jul 4, 2024 · 5 shares · 182 followers View post →

Manoj Mayogi Mishra

@mayogisense · X

RT @Madam_Mito: TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport | Nature Communicati…

Jul 3, 2024 · 5 shares · 572 followers View post →

T-MaX84

@max_ev_84 · X

RT @Madam_Mito: TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport | Nature Communicati…

Jul 3, 2024 · 5 shares · 1,462 followers View post →

Madam Mitochondria

@Madam_Mito · X

RT @Madam_Mito: TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport | Nature Communicati…

Jul 3, 2024 · 5 shares · 10,309 followers View post →

fengfengfeng666

@fengfeng667 · X

RT @cell_club: TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport https://t.co/gp9LKVT3…

Mar 15, 2023 · 11 shares · 20 followers View post →

ACT88FG4

@Act88F · X

RT @cell_club: TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport https://t.co/gp9LKVT3…

Mar 14, 2023 · 11 shares · 15 followers View post →

J. Fernando Bazan @jfernandobazan.bsky.social

@jfernandobazan · X

RT @cell_club: TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport https://t.co/gp9LKVT3…

Mar 14, 2023 · 11 shares · 706 followers View post →

Anastasia Shebanova

@StasyaS · X

RT @cell_club: TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport https://t.co/gp9LKVT3…

Mar 14, 2023 · 11 shares · 65 followers View post →

Keizo Nishikawa

@ihaveapenpai · X

RT @philosophising4: TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport | Nature Commun…

Mar 14, 2023 · 5 shares · 52 followers View post →

Gilles Gouspillou

@GGouspillou · X

RT @cell_club: TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport https://t.co/gp9LKVT3…

Mar 14, 2023 · 11 shares · 1,820 followers View post →

Madam Mitochondria

@Madam_Mito · X

TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport | Nature Communications https://t.co/rds3rbtvqr

Mar 13, 2023 · 14 likes · 5 shares · 10,309 followers View post →

Ruben QC

@RubenQC_Lab · X

RT @cell_club: TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport https://t.co/gp9LKVT3…

Mar 13, 2023 · 11 shares · 2,551 followers View post →

jebus christoff

@codo_nabu · X

RT @cell_club: TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport https://t.co/gp9LKVT3…

Mar 13, 2023 · 11 shares · 131 followers View post →

myosin actin crazy

@myosinactncrazy · X

RT @cell_club: TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport https://t.co/gp9LKVT3…

Mar 13, 2023 · 11 shares · 1,407 followers View post →

J Xrp

@shibrider · X

RT @cell_club: TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport https://t.co/gp9LKVT3…

Mar 13, 2023 · 11 shares · 657 followers View post →

Zu-Hang Sheng

@zuhangsheng · X

RT @cell_club: TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport https://t.co/gp9LKVT3…

Mar 13, 2023 · 11 shares · 472 followers View post →

Takuya Norizuki

@T_Norizuki · X

RT @cell_club: TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport https://t.co/gp9LKVT3…

Mar 13, 2023 · 11 shares · 281 followers View post →

Cell Biology J-Club

@cell_club · X

TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport https://t.co/gp9LKVT3LK

Mar 13, 2023 · 38 likes · 11 shares · 6,110 followers View post →

TRAK adaptors regulate the recruitment and activation of dynein and kinesin in mitochondrial transport.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

TRAK Adaptors Regulate Mitochondrial Transport via Dynein and Kinesin Activation