PubHawk
Vet Med Sci May 2023 PMID 36920334

Evaluation of the in vitro and in vivo effect of liposomal doxorubicin along with oncolytic Newcastle disease virus on 4T1 cell line: Animal preclinical research.

Pooya Faranoush, Alireza Jahandideh, Reza Nekouian, Pejman Mortazavi

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12
Peak: 1 in Mar 2023
across 4 sources since Mar 2023

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808
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Mar 2023 – Jun 2025

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  • News9 articles
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AI synopsis

What people are saying

The discussions generally recognize the promising therapeutic effects, such as increased tumor-suppressor gene expression and apoptosis, using words like 'potential' and 'promising,' but also reflect cautious optimism with mentions of 'further research needed,' indicating a moderate level of impact and engagement.

AgreementModerate agreement

Most posts acknowledge the promising findings about NDV and liposomal doxorubicin, showing overall support.

InterestModerate interest

Discussions reflect moderate interest, with some posts highlighting the potential therapeutic benefits but few expressing strong enthusiasm.

EngagementModerate engagement

The comments involve some technical details about apoptosis and gene expression, indicating a moderate level of engagement.

ImpactNeutral impact

While some posts recognize the potential impact of combining these treatments, concerns about safety and further research dampen enthusiasm for immediate application.

Abstract in brief

  • The study explores the combined effects of liposomal doxorubicin and the oncolytic Newcastle disease virus (NDV) on breast cancer cells (specifically the 4T1 cell line) in both cell cultures and animal models, showing potential for targeted cancer therapy.
  • Results indicate that NDV treatment increases the expression of tumor-suppressor genes (P21, P27, P53), promotes apoptosis, and reduces tumor growth without harming normal tissues, suggesting a promising role for NDV in cancer treatment.
  • The findings suggest that combining NDV with chemotherapy may improve cancer prognosis, but further research is needed to understand all conditions and safety aspects of this approach.]
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Phage Papers
@Phage_Papers · X

Evaluation of the in vitro and in vivo effect of liposomal doxorubicin along with oncolytic Newcastle disease virus on 4T1 cell line: Animal preclinical research https://t.co/MOTd9AdGVW

Mar 15, 2023 · 644 followers View post →

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Phage Papers
@Phage_Papers · X

Evaluation of the in vitro and in vivo effect of liposomal doxorubicin along with oncolytic Newcastle disease virus on 4T1 cell line: Animal preclinical research https://t.co/MOTd9AdGVW

Mar 15, 2023 · 644 followers View post →
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