PubHawk
PLoS Biol March 2023 PMID 36930682

TDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A.

Yuka Koike, Sarah Pickles, Virginia Estades Ayuso, Karen Jansen-West, Yue A Qi, Ziyi Li, Lillian M Daughrity, Mei Yue, Yong-Jie Zhang, Casey N Cook, Dennis W Dickson, Michael Ward, Leonard Petrucelli, Mercedes Prudencio

Full text PDF Download social card

Mentions

26
Peak: 19 in Mar 2023
across 3 sources since Mar 2023

Extended reach

452,145
potential audience

Total likes

39

Video views

144

Mentions per month

Mar 2023 – Aug 2023

Where it's discussed

  • X / Twitter22 posts
  • News3 articles
  • YouTube1 videos

AI synopsis

What people are saying

The discussions reflect a positive outlook towards the study, with phrases like 'excited for the upcoming manuscript' and mentions of 'potential disease modifiers,' which show curiosity and optimism. The tone and references to the biological mechanisms suggest an appreciation of the scientific significance and potential clinical impact of the findings.

AgreementModerate agreement

Most comments acknowledge the significance of the research, with some expressing enthusiasm about its potential impact on understanding ALS and FTD.

InterestHigh interest

Discussions demonstrate high curiosity, especially around the roles of TDP-43 and hnRNP proteins in disease mechanisms.

EngagementModerate engagement

Participants reference specific research findings and potential implications, indicating moderate to deep engagement.

ImpactModerate impact

The posts highlight the research's importance for disease understanding and future therapies, signifying moderate perceived impact.

Abstract in brief

  • TDP43 normally represses the inclusion of cryptic exons, including one in the UNC13A gene, which is linked to ALS and FTD, preventing harmful RNA changes.
  • The study found that the extreme N-terminus of TDP43 and other hnRNP proteins like hnRNP L, A1, and A2B1 independently help repress the cryptic exon in UNC13A, with hnRNP L levels being lower in diseased brains.
  • These results suggest that while TDP43 is the main regulator, other hnRNPs also play a role in controlling cryptic exon inclusion, potentially influencing disease progression in ALS and FTD.]
Read the full abstract

Top posts

Most liked on X and Bluesky
PrudencioLab
@PrudencioLab · X

https://t.co/tLOaDrMuWj so excited our next manuscript is coming out! @PLOSBiology Dr Koike (@Petrudelli lab) did a wonderful job from and Virginia Estades Ayuso from @PrudencioLab

Mar 19, 2023 · 20 likes · 8 shares · 133 followers View post →
ShorterLab
@ShorterLab · X

TDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A: https://t.co/Z6ni8QllO3

Aug 2, 2023 · 11 likes · 12,042 followers View post →
PLOS Biology
@PLOSBiology · X

TDP-43 represses cryptic exon splicing in #UNC13A, a risk factor for #AmyotrophicLateralSclerosis (#ALS) & #FrontotemporalDementia (#FTD). While #TDP43 is the main repressor, other hnRNPs may potentially act as disease modifiers @PrudencioLab #PLOSBiology https://t.co/QjRUd8Ji6K https://t.co/qYrI7C6lp5

Mar 20, 2023 · 2 likes · 1 share · 103,151 followers View post →
PrudencioLab
@PrudencioLab · X

https://t.co/tLOaDrMuWj

Jul 19, 2023 · 2 likes · 133 followers View post →
PLOS Biology
@PLOSBiology · X

TDP-43 represses cryptic exon splicing in #UNC13A, a risk factor for #AmyotrophicLateralSclerosis (#ALS) & #FrontotemporalDementia (#FTD). While #TDP43 is the main repressor, other hnRNPs may potentially act as disease modifiers @PrudencioLab #PLOSBiology https://t.co/QjRUd8Ji6K https://t.co/RVdqRL0gYY

Mar 20, 2023 · 1 like · 2 shares · 103,151 followers View post →
PLOS Biology
@PLOSBiology · X

TDP-43 represses cryptic exon splicing in #UNC13A, a risk factor for #AmyotrophicLateralSclerosis (#ALS) & #FrontotemporalDementia (#FTD). While #TDP43 is the main repressor, other hnRNPs may potentially act as disease modifiers @PrudencioLab #PLOSBiology https://t.co/QjRUd8Ji6K https://t.co/OBzgBP1KDo

Mar 20, 2023 · 1 like · 1 share · 103,151 followers View post →

All mentions

ShorterLab
@ShorterLab · X

TDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A: https://t.co/Z6ni8QllO3

Aug 2, 2023 · 11 likes · 12,042 followers View post →
PrudencioLab
@PrudencioLab · X

https://t.co/tLOaDrMuWj

Jul 19, 2023 · 2 likes · 133 followers View post →
My Neuropath News
@NeuropathClinic · X

TDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A #neuropath https://t.co/XYyKF5atTU

Apr 1, 2023 · 1,572 followers View post →
Sahba Seddighi
@SahbaSeddighi · X

RT @PrudencioLab: https://t.co/tLOaDrMuWj so excited our next manuscript is coming out! @PLOSBiology Dr Koike (@Petrudelli lab) did a wond…

Mar 23, 2023 · 8 shares · 71 followers View post →
Fergal Waldron
@FergalWaldron · X

RT @PrudencioLab: https://t.co/tLOaDrMuWj so excited our next manuscript is coming out! @PLOSBiology Dr Koike (@Petrudelli lab) did a wond…

Mar 21, 2023 · 8 shares · 388 followers View post →
PrudencioLab
@PrudencioLab · X

RT @PLOSBiology: TDP-43 represses cryptic exon splicing in #UNC13A, a risk factor for #AmyotrophicLateralSclerosis (#ALS) & #Frontotemporal…

Mar 20, 2023 · 1 share · 133 followers View post →
Oscar Wilkins
@OscarWilkins16 · X

RT @PrudencioLab: https://t.co/tLOaDrMuWj so excited our next manuscript is coming out! @PLOSBiology Dr Koike (@Petrudelli lab) did a wond…

Mar 20, 2023 · 8 shares · 248 followers View post →
AL Brown
@annaleighbrown2 · X

RT @PrudencioLab: https://t.co/tLOaDrMuWj so excited our next manuscript is coming out! @PLOSBiology Dr Koike (@Petrudelli lab) did a wond…

Mar 20, 2023 · 8 shares · 279 followers View post →
Celeste Karch
@karchlab · X

RT @PLOSBiology: TDP-43 represses cryptic exon splicing in #UNC13A, a risk factor for #AmyotrophicLateralSclerosis (#ALS) & #Frontotemporal…

Mar 20, 2023 · 2 shares · 4,279 followers View post →
PLOS Biology
@PLOSBiology · X

TDP-43 represses cryptic exon splicing in #UNC13A, a risk factor for #AmyotrophicLateralSclerosis (#ALS) & #FrontotemporalDementia (#FTD). While #TDP43 is the main repressor, other hnRNPs may potentially act as disease modifiers @PrudencioLab #PLOSBiology https://t.co/QjRUd8Ji6K https://t.co/OBzgBP1KDo

Mar 20, 2023 · 1 like · 1 share · 103,151 followers View post →
Ivan Alfaro
@alfobioq · X

RT @PLOSBiology: TDP-43 represses cryptic exon splicing in #UNC13A, a risk factor for #AmyotrophicLateralSclerosis (#ALS) & #Frontotemporal…

Mar 20, 2023 · 1 share · 821 followers View post →
PLOS Biology
@PLOSBiology · X

TDP-43 represses cryptic exon splicing in #UNC13A, a risk factor for #AmyotrophicLateralSclerosis (#ALS) & #FrontotemporalDementia (#FTD). While #TDP43 is the main repressor, other hnRNPs may potentially act as disease modifiers @PrudencioLab #PLOSBiology https://t.co/QjRUd8Ji6K https://t.co/qYrI7C6lp5

Mar 20, 2023 · 2 likes · 1 share · 103,151 followers View post →
PrudencioLab
@PrudencioLab · X

RT @PLOSBiology: TDP-43 represses cryptic exon splicing in #UNC13A, a risk factor for #AmyotrophicLateralSclerosis (#ALS) & #Frontotemporal…

Mar 20, 2023 · 2 shares · 133 followers View post →
PLOS Biology
@PLOSBiology · X

TDP-43 represses cryptic exon splicing in #UNC13A, a risk factor for #AmyotrophicLateralSclerosis (#ALS) & #FrontotemporalDementia (#FTD). While #TDP43 is the main repressor, other hnRNPs may potentially act as disease modifiers @PrudencioLab #PLOSBiology https://t.co/QjRUd8Ji6K https://t.co/RVdqRL0gYY

Mar 20, 2023 · 1 like · 2 shares · 103,151 followers View post →
My Neuropath News
@NeuropathClinic · X

TDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A #neuropath https://t.co/XYyKF5atTU

Mar 20, 2023 · 1,572 followers View post →
PLOS Biology
@PLOSBiology · X

RT @PrudencioLab: https://t.co/tLOaDrMuWj so excited our next manuscript is coming out! @PLOSBiology Dr Koike (@Petrudelli lab) did a wond…

Mar 20, 2023 · 8 shares · 103,151 followers View post →
ShorterLab
@ShorterLab · X

RT @PrudencioLab: https://t.co/tLOaDrMuWj so excited our next manuscript is coming out! @PLOSBiology Dr Koike (@Petrudelli lab) did a wond…

Mar 19, 2023 · 8 shares · 12,042 followers View post →
Belle Yu
@inBelleYuAble · X

RT @PrudencioLab: https://t.co/tLOaDrMuWj so excited our next manuscript is coming out! @PLOSBiology Dr Koike (@Petrudelli lab) did a wond…

Mar 19, 2023 · 8 shares · 120 followers View post →
Celeste Karch
@karchlab · X

RT @PrudencioLab: https://t.co/tLOaDrMuWj so excited our next manuscript is coming out! @PLOSBiology Dr Koike (@Petrudelli lab) did a wond…

Mar 19, 2023 · 8 shares · 4,279 followers View post →
PrudencioLab
@PrudencioLab · X

https://t.co/tLOaDrMuWj so excited our next manuscript is coming out! @PLOSBiology Dr Koike (@Petrudelli lab) did a wonderful job from and Virginia Estades Ayuso from @PrudencioLab

Mar 19, 2023 · 20 likes · 8 shares · 133 followers View post →
Yuka
@yukkoike14 · X

Released online! Author Info | PLOS Biology https://t.co/1L98ipevuK

Mar 18, 2023 · 19 followers View post →
Dataemia
@Dataemia · X

TDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A - https://t.co/QsOM22eMYG -

Mar 17, 2023 · 969 followers View post →