May 2023 PMID 36934969

Supression Thioredoxin reductase 3 exacerbates the progression of liver cirrhosis via activation of ferroptosis pathway.

Qi Liu, Liming Xu, Guangming Ren, Jingzhuang Zhao, Yizhi Shao, Tongyan Lu

Mentions

3
Peak: 2 in Oct 2025
across 2 sources since Mar 2023

Extended reach

4,903
potential audience

Total likes

442

Video views

4,616

Mentions per month

Mar 2023 – Oct 2025

Where it's discussed

  • YouTube2 videos
  • X / Twitter1 posts

AI synopsis

What people are saying

Discussions reflect a moderate level of interest and agreement, with posts emphasizing key findings like the role of Txnrd3 in protecting against ferroptosis, and expressing approval of the research, as seen in phrases like 'exacerbates liver damage' and 'activation of ferroptosis pathway'. The tone is informative yet reserved, suggesting a recognition of the study's importance but with some cautious optimism about its broader implications.

AgreementModerate agreement

Most discussions acknowledge the significance of the study, with some expressing strong support for its findings and conclusions.

InterestModerate interest

Participants show moderate interest, mentioning specific biological pathways, such as ferroptosis and iron overload, indicating engagement with the topic.

EngagementNeutral engagement

The posts are primarily reactions or brief comments, with limited deep analysis or critique; some show curiosity about implications.

ImpactModerate impact

While some discussions highlight the potential for new treatments or research directions, overall, impact perceptions are cautiously optimistic without widespread assertion of transformative change.

Abstract in brief

  • Suppression of Thioredoxin reductase 3 (Txnrd3) worsens liver cirrhosis by activating ferroptosis, a form of cell death related to iron overload, leading to increased liver damage in mice.
  • The study found that mice with reduced Txnrd3 exhibited more iron accumulation and lower levels of GPX4, a protein that protects against ferroptosis, which contributed to liver injury and cirrhosis.
  • In vitro experiments showed that knocking down Txnrd3 in liver cells increased iron overload and ferroptosis activity, suggesting that Txnrd3 plays a protective role in preventing iron-related liver damage.

Top posts

Most liked on X and Bluesky
IronBiologyBot
@IronBiologyBot · X

Supression thioredoxin reductase 3 exacerbates the progression of liver cirrhosis via activation of ferroptosis pathway https://t.co/lGjFaBN1vu #IronBiology #BioIron #Iron

Mar 20, 2023 · 288 followers View post →

All mentions

IronBiologyBot
@IronBiologyBot · X

Supression thioredoxin reductase 3 exacerbates the progression of liver cirrhosis via activation of ferroptosis pathway https://t.co/lGjFaBN1vu #IronBiology #BioIron #Iron

Mar 20, 2023 · 288 followers View post →