Nat Commun March 2023 PMID 36941260

Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in systemic lupus erythematosus.

Eduardo Gomez-Bañuelos, Yikai Yu, Jessica Li, Kevin S Cashman, Merlin Paz, Maria Isabel Trejo-Zambrano, Regina Bugrovsky, Youliang Wang, Asiya Seema Chida, Cheryl A Sherman-Baust, Dylan P Ferris, Daniel W Goldman, Erika Darrah, Michelle Petri, Iñaki Sanz

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Mentions

9
Peak: 3 in Mar 2023
across 4 sources since Mar 2023

Extended reach

11,888
potential audience

Total likes

24

Video views

102

Mentions per month

Mar 2023 – Jun 2023

Where it's discussed

  • X / Twitter3 posts
  • Facebook3 posts
  • News2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The discussions consistently recognize the importance of the study, using phrases like 'affinity maturation' and 'pathogenic antibodies,' which convey technical interest, while the tone remains analytical rather than emotional. The emphasis on specific immune mechanisms illustrates engagement, but the brevity implies a moderate level of depth without extensive elaboration.

AgreementNeither agree nor disagree

The posts acknowledge the study's findings but do not express strong support or disagreement, indicating moderate agreement.

InterestHigh interest

Posts show high interest, referencing specific details like the dual reactivity of antibodies and mentioning the publication explicitly.

EngagementModerate engagement

Some discussions suggest engagement through sharing summaries or implications, but limited depth is evident.

ImpactModerate impact

While the posts highlight the significance of understanding pathogenic antibodies in SLE, they suggest a moderate impact rather than revolutionary influence.

Abstract in brief

  • The study finds that certain autoantibodies in Systemic Lupus Erythematosus (SLE) patients target both the enzyme DNase1L3 and double-stranded DNA (dsDNA), and these antibodies are more damaging than those targeting only dsDNA.
  • These antibodies can be divided into two groups based on their genetic origins: one arises from germline-encoded precursors and gains crossreactivity to dsDNA after mutation, while the other originates from diverse gene segments with varying affinity after maturation.
  • Overall, the research suggests that DNase1L3 is a primary target of these pathogenic antibodies, shedding light on their diverse origins and roles in disease development.]

Top posts

Most liked on X and Bluesky
Waggoner Lab
@LabWaggoner · X

Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in SLE @NatureComms #Andrade https://t.co/7C3Rv6id1u

Mar 20, 2023 · 24 likes · 3 shares · 11,306 followers View post →
Jamil Jubrail
@Jamil_Jubrail · X

RT @LabWaggoner: Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in SLE @NatureComms #Andrad…

Mar 21, 2023 · 3 shares · 397 followers View post →

All mentions

Anastasia Shebanova
@StasyaS · X

RT @LabWaggoner: Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in SLE @NatureComms #Andrad…

Mar 22, 2023 · 3 shares · 65 followers View post →
Jamil Jubrail
@Jamil_Jubrail · X

RT @LabWaggoner: Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in SLE @NatureComms #Andrad…

Mar 21, 2023 · 3 shares · 397 followers View post →
Waggoner Lab
@LabWaggoner · X

Affinity maturation generates pathogenic antibodies with dual reactivity to DNase1L3 and dsDNA in SLE @NatureComms #Andrade https://t.co/7C3Rv6id1u

Mar 20, 2023 · 24 likes · 3 shares · 11,306 followers View post →