PubHawk
Intensive Care Med May 2023 PMID 36943442

Is the U-shaped curve still of relevance to oxygenation of critically ill patients?

Daniel Martin, Audrey de Jong, Peter Radermacher

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Mentions

46
Peak: 42 in Mar 2023
across 3 sources since Mar 2023

Extended reach

293,038
potential audience

Total likes

143

Video views

449

Mentions per month

Mar 2023 – Apr 2023

Where it's discussed

  • X / Twitter41 posts
  • Facebook3 posts
  • YouTube2 videos

AI synopsis

What people are saying

Several discussions emphasize questions about whether the U-shaped curve remains applicable, with users expressing curiosity and skepticism, such as 'Inconclusive results' and references to the 'methods to establish O2/mortality relationship.' The tone reflects cautious engagement, with some posts exploring the complexity and current uncertainties around oxygen management in critically ill patients, indicating an active but mixed-level interest in the topic's practical implications.

AgreementNeither agree nor disagree

The discussions show mixed reactions; some posts question the continued relevance of the U-shaped curve, while others imply ongoing debate, leading to a neutral overall stance.

InterestHigh interest

Posts exhibit high curiosity, with multiple questions about the significance and application of the concept, indicating strong engagement with the topic.

EngagementModerate engagement

Most posts reference the core debate, such as the relevance of the U-shaped curve, and include comments about the complexity and current inconclusive evidence, highlighting thoughtful consideration.

ImpactNeutral impact

The discussions suggest that while the topic is intriguing, there is no consensus on its impact; some posts hint at implications for clinical practice, but overall, the perceived impact appears moderate.

Abstract in brief

  • The U-shaped curve in oxygenation refers to the idea that both too little and too much oxygen can be harmful to critically ill patients, emphasizing the importance of maintaining optimal oxygen levels.
  • Recent research questions whether this traditional concept still applies, given new evidence and advanced medical practices that might alter the balance between hypoxia (low oxygen) and hyperoxia (high oxygen).
  • The debate suggests that understanding the precise oxygen targets remains crucial for improving patient outcomes, but the relevance of the U-shaped curve in current clinical settings is still under investigation.]
Read the full abstract

Top posts

Most liked on X and Bluesky
Intensive Care Medicine
@yourICM · X

O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distribution: methods to establish O2/mortality relationship rely on accurate/reliable data. Current results? Inconclusive! #FOAMcc

Mar 22, 2023 · 83 likes · 34 shares · 75,397 followers View post →
集中治療クラブ
@intensivecare_c · X

酸素化と死亡率の関係。 酸素分圧は低すぎても高すぎてもダメで、死亡率はU字型になるというのは本当か？ https://t.co/U5jewEdTIY https://t.co/WcmIYG3zG1

Mar 24, 2023 · 41 likes · 4 shares · 13,500 followers View post →
ESICM
@ESICM · X

2/

Mar 24, 2023 · 16 likes · 10 shares · 42,466 followers View post →
Intensive Care Medicine
@yourICM · X

RT @ESICM: 2/

Mar 28, 2023 · 10 shares · 75,397 followers View post →
Fede Gordo-Vidal
@ventilacionmeca · X

RT @yourICM: O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distr…

Mar 22, 2023 · 34 shares · 24,650 followers View post →
M Velia Antonini
@FOAMecmo · X

RT @yourICM: O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distr…

Mar 22, 2023 · 34 shares · 14,657 followers View post →

All mentions

Syed Shahrul Naz
@drshahrul80 · X

RT @ESICM: 2/

Apr 3, 2023 · 10 shares · 6,926 followers View post →
Ghonchu Ram
@GhonchuR · X

RT @ESICM: 2/

Mar 29, 2023 · 10 shares · 3 followers View post →
Marden Junio
@MardenJunio1 · X

RT @ESICM: 2/

Mar 28, 2023 · 10 shares · 143 followers View post →
Intensive Care Medicine
@yourICM · X

RT @ESICM: 2/

Mar 28, 2023 · 10 shares · 75,397 followers View post →
Romain Batton, MD, MSc
@romain_bttn · X

RT @ESICM: 2/

Mar 27, 2023 · 10 shares · 36 followers View post →
Girardis Massimo
@maxdulac · X

RT @ESICM: 2/

Mar 26, 2023 · 10 shares · 305 followers View post →
ハンバーグ太郎
@karaagelove06 · X

RT @intensivecare_c: 酸素化と死亡率の関係。 酸素分圧は低すぎても高すぎてもダメで、死亡率はU字型になるというのは本当か？ https://t.co/U5jewEdTIY https://t.co/WcmIYG3zG1

Mar 25, 2023 · 4 shares · 144 followers View post →
Matthieu Evrard
@MatthieuEvrard3 · X

RT @ESICM: 2/

Mar 25, 2023 · 10 shares · 191 followers View post →
おれんじ色
@orangeiro7 · X

RT @intensivecare_c: 酸素化と死亡率の関係。 酸素分圧は低すぎても高すぎてもダメで、死亡率はU字型になるというのは本当か？ https://t.co/U5jewEdTIY https://t.co/WcmIYG3zG1

Mar 25, 2023 · 4 shares · 1,802 followers View post →
かぜっぴき
@shiozyake · X

RT @intensivecare_c: 酸素化と死亡率の関係。 酸素分圧は低すぎても高すぎてもダメで、死亡率はU字型になるというのは本当か？ https://t.co/U5jewEdTIY https://t.co/WcmIYG3zG1

Mar 24, 2023 · 4 shares · 222 followers View post →
［C.I.M］corrupto ingeniero maquinaria（旧ろっとん）
@machineryMPS · X

RT @intensivecare_c: 酸素化と死亡率の関係。 酸素分圧は低すぎても高すぎてもダメで、死亡率はU字型になるというのは本当か？ https://t.co/U5jewEdTIY https://t.co/WcmIYG3zG1

Mar 24, 2023 · 4 shares · 628 followers View post →
集中治療クラブ
@intensivecare_c · X

酸素化と死亡率の関係。 酸素分圧は低すぎても高すぎてもダメで、死亡率はU字型になるというのは本当か？ https://t.co/U5jewEdTIY https://t.co/WcmIYG3zG1

Mar 24, 2023 · 41 likes · 4 shares · 13,500 followers View post →
Dr. Chacón-Lozsán F .'.
@franciscojlk · X

RT @ESICM: 2/

Mar 24, 2023 · 10 shares · 763 followers View post →
sunil
@sillisuni · X

RT @ESICM: 2/

Mar 24, 2023 · 10 shares · 20 followers View post →
Katia Donadello
@KatiaDonadello · X

RT @ESICM: 2/

Mar 24, 2023 · 10 shares · 1,201 followers View post →
ESICM
@ESICM · X

2/

Mar 24, 2023 · 16 likes · 10 shares · 42,466 followers View post →
ppick
@ppick19 · X

RT @yourICM: O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distr…

Mar 22, 2023 · 34 shares · 12 followers View post →
Vale (V.B.)
@vaivale · X

RT @yourICM: O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distr…

Mar 22, 2023 · 34 shares · 75 followers View post →
INTERNAL MEDICINE
@medicinterna · X

RT @yourICM: O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distr…

Mar 22, 2023 · 34 shares · 2,456 followers View post →
Ingridlly
@Ingridlly · X

RT @yourICM: O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distr…

Mar 22, 2023 · 34 shares · 187 followers View post →
Iván Bajaña
@IvanReneBajana · X

RT @yourICM: O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distr…

Mar 22, 2023 · 34 shares · 152 followers View post →
M Velia Antonini
@FOAMecmo · X

RT @yourICM: O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distr…

Mar 22, 2023 · 34 shares · 14,657 followers View post →
Ricardo Treml MD, DESAIC.
@TremlRicardo · X

RT @yourICM: O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distr…

Mar 22, 2023 · 34 shares · 14 followers View post →
Marden Junio
@MardenJunio1 · X

RT @yourICM: O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distr…

Mar 22, 2023 · 34 shares · 143 followers View post →
Dr. Awuor Ondeng (MBChB)
@AwuorOndeng · X

RT @yourICM: O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distr…

Mar 22, 2023 · 34 shares · 1,425 followers View post →
Scuola ARTID Firenze UNIFI
@UnifiArtid · X

RT @yourICM: O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distr…

Mar 22, 2023 · 34 shares · 25 followers View post →
Fabio Varon MD. MsC. PhD.
@FABIOVARON · X

RT @yourICM: O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distr…

Mar 22, 2023 · 34 shares · 3,052 followers View post →
#intensivistadeguardia
@intensivoonfire · X

RT @yourICM: O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distr…

Mar 22, 2023 · 34 shares · 5,892 followers View post →
Villahermosa se vistió de fiesta con la primavera
@Gust_1971 · X

RT @yourICM: O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distr…

Mar 22, 2023 · 34 shares · 490 followers View post →
Medicina Crítica Mex
@MedCriticaMex · X

RT @yourICM: O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distr…

Mar 22, 2023 · 34 shares · 2,978 followers View post →
bruno guimaraes
@brunoguimaraesp · X

RT @yourICM: O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distr…

Mar 22, 2023 · 34 shares · 91 followers View post →
Fede Gordo-Vidal
@ventilacionmeca · X

RT @yourICM: O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distr…

Mar 22, 2023 · 34 shares · 24,650 followers View post →
Audrey De Jong
@audreydejongMD · X

RT @yourICM: O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distr…

Mar 22, 2023 · 34 shares · 1,300 followers View post →
SECIP
@lasecip · X

Is the U-shaped curve still of relevance to oxygenation of critically ill patients? https://t.co/0MPYlAmyKm #IntCareMed

Mar 22, 2023 · 5,612 followers View post →
JOSE URCIA VAZALLO
@JOSEURCIA · X

RT @yourICM: O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distr…

Mar 22, 2023 · 34 shares · 305 followers View post →
Francisco Mandiola A
@FrMandiola · X

RT @yourICM: O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distr…

Mar 22, 2023 · 34 shares · 167 followers View post →
Skyperson 2.0
@skyperson · X

RT @yourICM: O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distr…

Mar 22, 2023 · 34 shares · 3,530 followers View post →
Libert Nicolas
@dr_Libert_N · X

RT @yourICM: O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distr…

Mar 22, 2023 · 34 shares · 54 followers View post →
Silvio A. Ñamendys-Silva
@snamendys · X

RT @yourICM: O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distr…

Mar 22, 2023 · 34 shares · 3,696 followers View post →
Cardiac Arrest Center - Ospedale San Raffaele
@SRCardiacArrest · X

RT @yourICM: O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distr…

Mar 22, 2023 · 34 shares · 591 followers View post →
Intensive Care Medicine
@yourICM · X

O2 in #ICU? ➡️ every drug has effective/toxic dose: O2 no exception... but ➡️ any U-shaped curve is derived from bimodal distribution: methods to establish O2/mortality relationship rely on accurate/reliable data. Current results? Inconclusive! #FOAMcc

Mar 22, 2023 · 83 likes · 34 shares · 75,397 followers View post →