Nat Commun March 2023 PMID 36949070

Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer.

Kelsy C Cotto, Yang-Yang Feng, Avinash Ramu, Megan Richters, Sharon L Freshour, Zachary L Skidmore, Huiming Xia, Joshua F McMichael, Jason Kunisaki, Katie M Campbell, Timothy Hung-Po Chen, Emily B Rozycki, Douglas Adkins, Siddhartha Devarakonda, Sumithra Sankararaman

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Peak: 48 in Mar 2023

across 2 sources since Jan 2021

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What people are saying

Many discussions emphasize the importance of the publication's results, with phrases like 'nice resource paper' and mentions of specific tools such as RegTools highlighting the innovation in analyzing splice variants. The tone, characterized by expressions of enthusiasm and acknowledgment of the research's relevance, contributes to the overall positive sentiment stating that the findings can advance understanding in cancer genomics.

AgreementModerate agreement

While some posts express general support, there is a notable lack of critical engagement or disagreement with the publication's findings.

InterestHigh interest

The majority of discussions indicate high curiosity and relevance to the topic of cancer genomics, reflected in the frequent mentions of splice-associated variants.

EngagementModerate engagement

Posts mainly reference the publication and its authors, with limited deep analysis or personal insights.

ImpactHigh impact

Users generally perceive the findings to have significant implications for cancer research and treatment, especially regarding the identification of splice-associated variants.

Abstract in brief

Somatic mutations in non-coding regions and exons can have hidden regulatory effects that are often missed in genetic analysis.
RegTools is a free, open-source software that links somatic variants from genomic data to splice junctions, helping identify variants that may lead to abnormal splicing, applied in over 9000 tumor samples.
The tool discovered over 235,000 splicing events related to specific junctions, with the ability to analyze variants in key cancer genes like TP53 and CDKN2A, showcasing its effectiveness compared to other analysis methods.

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Discovering Splice-Associated Variants in Cancer Genomics

This video discusses the integrated analysis of genomic and transcriptomic data to discover splice-associated variants in cancer. It highlights the use of RegTools software to link somatic variants to splice junctions…

STEM RTCL TV · Jun 14, 2023 30 views

Providence Swedish Cancer Institute Research

@ProvSwedCancRes · X

Dr. Sid Devarakonda @ProvSwedish publishes in @NatureComms on new tools for analyzing cancer #genomic data to identify key events in #lungcancer https://t.co/oKcXS5RNCg

Jun 1, 2023 · 94 followers View post →

fuzzyLife

@animesh1977 · X

RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 30, 2023 · 40 shares · 1,738 followers View post →

CancerLinks 

@CancerLinks · X

RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 28, 2023 · 40 shares · 97 followers View post →

Takashi Kohno@Natl Cancer Ctr, Japan

@TakashiKohno2 · X

RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 25, 2023 · 40 shares · 596 followers View post →

ddhb

@ddhb80180543 · X

RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 25, 2023 · 40 shares · 15 followers View post →

Rene Sugar

@renesugar · X

Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer https://t.co/hB5OH4GvAx

Mar 25, 2023 · 3,951 followers View post →

filippo masini

@filimasini · X

RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 25, 2023 · 40 shares · 769 followers View post →

houruiyan

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RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 24, 2023 · 40 shares · 28 followers View post →

Transcriptomes

@transcriptomes · X

Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated... https://t.co/ljfbTrCXt6

Mar 24, 2023 · 1,808 followers View post →

Scott Stelpflug

@scott_stelpflug · X

RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 24, 2023 · 40 shares · 2,237 followers View post →

Srikanth S. Manda

@srithegreat143 · X

RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 24, 2023 · 40 shares · 174 followers View post →

Sherri Y Sorkhabi

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RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

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Fábio Fonseca

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RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

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Nature Reviews Methods Primers

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RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

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Zulfikar Azam

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RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 24, 2023 · 40 shares · 201 followers View post →

Humoud Adnan Y. Al-Shayji

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RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 24, 2023 · 40 shares · 197 followers View post →

Pat Adams

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RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 24, 2023 · 40 shares · 1,511 followers View post →

Ming "Tommy" Tang

@tangming2005 · X

RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 24, 2023 · 40 shares · 40,948 followers View post →

John Kenten

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RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 24, 2023 · 40 shares · 577 followers View post →

Andres F. Cardona

@AndresFCardonaZ · X

RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 24, 2023 · 40 shares · 8,821 followers View post →

Kristel Gonzalez

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RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 24, 2023 · 40 shares · 1,277 followers View post →

RARE-MED

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RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 24, 2023 · 40 shares · 514 followers View post →

Gaurav Jain

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RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 24, 2023 · 40 shares · 649 followers View post →

Espoir Kabanga (김희망)

@espoir_kabanga · X

RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 24, 2023 · 40 shares · 359 followers View post →

kato masaki

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RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 23, 2023 · 40 shares · 135 followers View post →

Tariq Nadeem

@Tariqbiotech27 · X

RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 23, 2023 · 40 shares · 620 followers View post →

Lum Lab

@lum_lab · X

RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 23, 2023 · 40 shares · 1,209 followers View post →

Artem Nedoluzhko

@nedoluzhko · X

RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 23, 2023 · 40 shares · 125 followers View post →

felix

@felixlee0608 · X

RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 23, 2023 · 40 shares · 28 followers View post →

Seungho Oh @seunghooh@genomic.social

@dancewithsun · X

RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 23, 2023 · 40 shares · 98 followers View post →

Alan Mejía Maza MSc, PhD

@alanmej55130600 · X

RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 23, 2023 · 40 shares · 627 followers View post →

Amit Rupani

@IAnalyzeGenomes · X

RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 23, 2023 · 40 shares · 362 followers View post →

ProgRET

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RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 23, 2023 · 40 shares · 298 followers View post →

Sehbanul Islam

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RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 23, 2023 · 40 shares · 644 followers View post →

Elfride De Baere

@elfridedebaere · X

RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 23, 2023 · 40 shares · 1,652 followers View post →

Luis Ferrández Peral

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RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 23, 2023 · 40 shares · 210 followers View post →

CancerLinks 

@CancerLinks · X

RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 23, 2023 · 40 shares · 97 followers View post →

Guillermo Parada

@ge_parada · X

RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 23, 2023 · 40 shares · 661 followers View post →

Bioinformatics Trends 

@BinfoTrends · X

RT @jsantoyo: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVari…

Mar 23, 2023 · 40 shares · 8,159 followers View post →

Javier Santoyo

@jsantoyo · X

Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer. #SpliceVariants #CancerGenomics @NatureComms https://t.co/kqqVc4urSx

Mar 23, 2023 · 116 likes · 40 shares · 6,100 followers View post →

Rene Sugar

@renesugar · X

RT @Loose_Lab_Rat: Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer https:/…

Mar 23, 2023 · 1 share · 3,951 followers View post →

Kelly A. Hogan Ph.D.

@Loose_Lab_Rat · X

Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer https://t.co/efmi5Lda1g

Mar 23, 2023 · 1 share · 2,240 followers View post →

minnlab_litbot

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Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer https://t.co/w9AQxzYOIU https://t.co/gIDdp5sdnJ

Mar 23, 2023 · 72 followers View post →

Eytan Ruppin, MD, PhD

@EytanRuppin · X

RT @Aiims1742: Nice resource paper in @NatureComms from Drs. @malachigriffith & @obigriffith Integrated analysis of genomic and transcript…

Mar 23, 2023 · 6 shares · 5,054 followers View post →

Andres F. Cardona

@AndresFCardonaZ · X

RT @Aiims1742: Nice resource paper in @NatureComms from Drs. @malachigriffith & @obigriffith Integrated analysis of genomic and transcript…

Mar 22, 2023 · 6 shares · 8,821 followers View post →

S. George Barreto

@sgeorgebarreto · X

RT @Aiims1742: Nice resource paper in @NatureComms from Drs. @malachigriffith & @obigriffith Integrated analysis of genomic and transcript…

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Federico Nichetti

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RT @Aiims1742: Nice resource paper in @NatureComms from Drs. @malachigriffith & @obigriffith Integrated analysis of genomic and transcript…

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Victoria Hendry

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RT @Aiims1742: Nice resource paper in @NatureComms from Drs. @malachigriffith & @obigriffith Integrated analysis of genomic and transcript…

Mar 22, 2023 · 6 shares · 1,319 followers View post →

Anirban Maitra

@Aiims1742 · X

Mar 22, 2023 · 21 likes · 6 shares · 31,228 followers View post →

GenomeResearch

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Jan 9, 2023 · 1 like · 4,086 followers View post →

Sagnik Banerjee

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RT @SeqComplete: #BioIT #BioInformatics RegTools: Integrated analysis of genomic and transcriptomic data for the discovery of splicing vari…

Apr 9, 2021 · 2 shares · 385 followers View post →

CompChemBio Bot

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RT @SeqComplete: #BioIT #BioInformatics RegTools: Integrated analysis of genomic and transcriptomic data for the discovery of splicing vari…

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SeqComplete

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#BioIT #BioInformatics RegTools: Integrated analysis of genomic and transcriptomic data for the discovery of splicing variants in cancer [NEW RESULTS] https://t.co/G2vfvIkuED

Apr 9, 2021 · 2 likes · 2 shares · 4,411 followers View post →

CompChemBio Bot

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RT @SeqComplete: #BioIT #BioInformatics RegTools: Integrated analysis of genomic and transcriptomic data for the discovery of splicing vari…

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SeqComplete

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#BioIT #BioInformatics RegTools: Integrated analysis of genomic and transcriptomic data for the discovery of splicing variants in cancer [NEW RESULTS] https://t.co/wqJXnn69Ay

Jan 6, 2021 · 1 like · 1 share · 4,411 followers View post →

Integrated analysis of genomic and transcriptomic data for the discovery of splice-associated variants in cancer.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Discovering Splice-Associated Variants in Cancer Genomics