Nat Commun March 2023 PMID 36949142

Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer's disease.

Annamaria Lia, Gabriele Sansevero, Angela Chiavegato, Miriana Sbrissa, Diana Pendin, Letizia Mariotti, Tullio Pozzan, Nicoletta Berardi, Giorgio Carmignoto, Cristina Fasolato, Micaela Zonta

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Mentions

22
Peak: 9 in Mar 2023
across 4 sources since Mar 2023

Extended reach

283,072
potential audience

Total likes

44

Video views

26

Mentions per month

Mar 2023 – Jun 2023

Where it's discussed

  • X / Twitter15 posts
  • News3 articles
  • Blogs3 articles
  • YouTube1 videos

AI synopsis

What people are saying

The discussions convey excitement about the research’s implications, with phrases like 'restores long-term synaptic plasticity' and mentions of improving reproducibility through RRIDs. The tone suggests a recognition of the study's potential to influence future therapeutic strategies, supported by details emphasizing the importance of calcium signaling in astrocytes and the experimental focus on female mice models.

AgreementModerate agreement

Most discussions emphasize the significance of the research findings, reflecting strong support for the potential of targeting STIM1 in Alzheimer's treatment.

InterestHigh interest

Posts demonstrate high curiosity and enthusiasm, with mentions of the innovative approach and implications for future therapies.

EngagementModerate engagement

Users actively discuss the scientific methods and importance, indicating moderate to deep engagement, such as referring to RRIDs and the restoration of calcium signaling.

ImpactHigh impact

Conversations highlight the potential for meaningful impact on Alzheimer's treatment and scientific reproducibility, stressing its promise for future research and clinical applications.

Abstract in brief

  • The study shows that in female mice with Alzheimer's disease, astrocytes (supportive brain cells) have reduced calcium signaling, which is linked to memory problems, and this occurs early when plaques first form in the brain.
  • The researchers found that boosting the levels of a calcium sensor protein called STIM1 in astrocytes can fully restore both calcium activity and long-term synaptic plasticity, leading to improvements in memory function.
  • This research suggests that astrocyte calcium hypoactivity is an early sign of Alzheimer's in the brain, and targeting STIM1 could be a promising approach to prevent or reverse memory loss in the disease.

Top posts

Most liked on X and Bluesky
New neuroscience papers in Nature Communications
@NeuroPaperBot · X

Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer’s disease https://t.co/ikZpqO7HfI

Mar 22, 2023 · 24 likes · 6 shares · 1,956 followers View post →
Nature Communications
@NatureComms · X

Work by @AnnamariaLia, @zontamicaela & colleagues shows that rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer’s disease. @CNRsocial_, @PhD_DSB_UniPD. https://t.co/8xBuZRSTQh

Apr 20, 2023 · 18 likes · 5 shares · 248,490 followers View post →
RRID Robot
@RobotRrid · X

RRIDs were included in the Nature Communications paper "Rescue of astrocyte activity by the calcium sensor…" (https://t.co/6lQutMJZQM). RRIDs like this improve reproducibility in scientific research. #accelerateopenscience #reproducibility

Mar 27, 2023 · 1 like · 161 followers View post →
CNR Consiglio Nazionale delle Ricerche
@CNRsocial_ · X

RT @NatureComms: Work by @AnnamariaLia, @zontamicaela & colleagues shows that rescue of astrocyte activity by the calcium sensor STIM1 rest…

Apr 20, 2023 · 5 shares · 22,471 followers View post →
PurPurPurkinje
@tak_yamm · X

RT @NatureComms: Work by @AnnamariaLia, @zontamicaela & colleagues shows that rescue of astrocyte activity by the calcium sensor STIM1 rest…

Apr 20, 2023 · 5 shares · 2,780 followers View post →
Victor V. Lobanenkov
@boris_ctcf · X

Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer’s disease. Nat Commun 14, 1590 (03-22-2023) https://t.co/lunyr8M2cO

Mar 23, 2023 · 2,046 followers View post →

All mentions

PhD in Biomedical Sciences - UNIPD
@PhD_DSB_UniPD · X

RT @NatureComms: Work by @AnnamariaLia, @zontamicaela & colleagues shows that rescue of astrocyte activity by the calcium sensor STIM1 rest…

Apr 20, 2023 · 5 shares · 591 followers View post →
Rothstein Lab
@Rothstein_Lab · X

RT @NatureComms: Work by @AnnamariaLia, @zontamicaela & colleagues shows that rescue of astrocyte activity by the calcium sensor STIM1 rest…

Apr 20, 2023 · 5 shares · 1,289 followers View post →
Massimo Chiaramonte
@MassimoChiaram7 · X

RT @NatureComms: Work by @AnnamariaLia, @zontamicaela & colleagues shows that rescue of astrocyte activity by the calcium sensor STIM1 rest…

Apr 20, 2023 · 5 shares · 842 followers View post →
CNR Consiglio Nazionale delle Ricerche
@CNRsocial_ · X

RT @NatureComms: Work by @AnnamariaLia, @zontamicaela & colleagues shows that rescue of astrocyte activity by the calcium sensor STIM1 rest…

Apr 20, 2023 · 5 shares · 22,471 followers View post →
PurPurPurkinje
@tak_yamm · X

RT @NatureComms: Work by @AnnamariaLia, @zontamicaela & colleagues shows that rescue of astrocyte activity by the calcium sensor STIM1 rest…

Apr 20, 2023 · 5 shares · 2,780 followers View post →
Nature Communications
@NatureComms · X

Work by @AnnamariaLia, @zontamicaela & colleagues shows that rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer’s disease. @CNRsocial_, @PhD_DSB_UniPD. https://t.co/8xBuZRSTQh

Apr 20, 2023 · 18 likes · 5 shares · 248,490 followers View post →
RRID Robot
@RobotRrid · X

RRIDs were included in the Nature Communications paper "Rescue of astrocyte activity by the calcium sensor…" (https://t.co/6lQutMJZQM). RRIDs like this improve reproducibility in scientific research. #accelerateopenscience #reproducibility

Mar 27, 2023 · 1 like · 161 followers View post →
Tau Neurodiscovery
@NeuroprotectLab · X

RT @NeuroPaperBot: Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling…

Mar 23, 2023 · 6 shares · 239 followers View post →
Victor V. Lobanenkov
@boris_ctcf · X

Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer’s disease. Nat Commun 14, 1590 (03-22-2023) https://t.co/lunyr8M2cO

Mar 23, 2023 · 2,046 followers View post →
Bataveljic
@BataveljicD · X

RT @NeuroPaperBot: Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling…

Mar 23, 2023 · 6 shares · 130 followers View post →
Seunghwan Choi, MD, PhD
@neuronchoi · X

RT @NeuroPaperBot: Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling…

Mar 23, 2023 · 6 shares · 57 followers View post →
AbizaidAlfie
@AbizaidAlfie · X

RT @NeuroPaperBot: Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling…

Mar 22, 2023 · 6 shares · 1,587 followers View post →
Mónica López Hidalgo
@LopezHidalgo_M · X

RT @NeuroPaperBot: Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling…

Mar 22, 2023 · 6 shares · 257 followers View post →
simaxiaoer
@Simao70053701 · X

RT @NeuroPaperBot: Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling…

Mar 22, 2023 · 6 shares · 7 followers View post →
New neuroscience papers in Nature Communications
@NeuroPaperBot · X

Rescue of astrocyte activity by the calcium sensor STIM1 restores long-term synaptic plasticity in female mice modelling Alzheimer’s disease https://t.co/ikZpqO7HfI

Mar 22, 2023 · 24 likes · 6 shares · 1,956 followers View post →