Commun Biol March 2023 PMID 36959276

Integrated-gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease.

Jiandong Yang, Yoshikazu Hirai, Kei Iida, Shinji Ito, Marika Trumm, Shiho Terada, Risako Sakai, Toshiyuki Tsuchiya, Osamu Tabata, Ken-Ichiro Kamei

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Mentions

15
Peak: 6 in Apr 2023
across 2 sources since Jun 2020

Extended reach

155,669
potential audience

Total likes

31

Video views

27

Mentions per month

Jun 2020 – Jul 2023

Where it's discussed

  • X / Twitter14 posts
  • YouTube1 videos

AI synopsis

What people are saying

The overall social discussions are highly supportive and curious, highlighting phrases like 'new in research' and tags such as #NAFLD and #organsonachip, which indicate strong interest in advancements and implications. The tone reflects excitement about the platform's potential to advance disease modeling and replace animal testing, demonstrating both academic engagement and perceived high impact.

AgreementModerate agreement

Most discussions express positive acknowledgment and support for the significance of the research, indicating agreement with its value and potential.

InterestHigh interest

The discussions show high interest, with multiple posts mentioning the innovative platform, potential impact, and collaborations, demonstrating curiosity and engagement.

EngagementModerate engagement

Posts include references to the methodology, collaborations, and implications, reflecting moderate to high engagement levels, especially among researchers and academics.

ImpactHigh impact

The discussions suggest that the research could significantly influence future NAFLD studies and organ-on-a-chip technology, emphasizing its innovative approach and potential to replace animal testing.

Abstract in brief

  • Non-alcoholic fatty liver disease (NAFLD) affects many people, but effective treatments are lacking due to limitations in current research methods.
  • The study introduces an integrated-gut-liver-on-a-chip (iGLC) system that simulates human gut-liver interactions by co-culturing gut and liver cell lines in a microfluidic environment, allowing for observation of NAFLD development.
  • Results show that gut-liver co-cultured cells can protect against fat-induced cell death, while providing insights into lipid accumulation and gene expression changes linked to cellular stress, suggesting the iGLC platform could replace animal testing for studying NAFLD.

Top posts

Most liked on X and Bluesky
Science Advancement and Outreach
@SAOscience · X

New in @CommsBio from @ken1kamei & @KyotoU_News colleagues: "Integrated-gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease" https://t.co/8UL4a4pag8 #NAFLD #OOC #humanrelevantresearch

Mar 30, 2023 · 7 likes · 1,246 followers View post →
Ken-ichiro Kamei
@ken1kamei · X

We put our recent achievement in collaboration with Jiandong, Hirai sensei, and Iida sensei about Organs-on-a-Chip in bioRxiv! "Integrated gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease" #organsonachip #nafld https://t.co/wKnYRmHow1

Jun 12, 2020 · 6 likes · 1 share · 469 followers View post →
The Lipid Chronicles
@lipidchronicles · X

Integrated-gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease - Communications Biology https://t.co/xooYfW8QdK (@CommsBio)

Mar 31, 2023 · 4 likes · 1 share · 5,847 followers View post →
iCeMS, Kyoto Univ - International
@iCeMS_KU_INTL · X

@ken1kamei @Eng_Kyoto_Univ Paper “Integrated gut–liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease” https://t.co/KYgWpYGkAX @CommsBio

Apr 7, 2023 · 3 likes · 1 share · 2,062 followers View post →
NMSLab Kyoto Univ
@NMSLabKyotoUniv · X

Paper Published. https://t.co/4f54EHREty

Mar 24, 2023 · 3 likes · 58 followers View post →
bioRxiv
@biorxivpreprint · X

Integrated gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease https://t.co/3gwyal7baV #bioRxiv

Jun 12, 2020 · 2 likes · 137,373 followers View post →

All mentions

Satoshi Endo
@biochemer · X

Integrated-gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease https://t.co/RuIdAE1a7o

Apr 10, 2023 · 1 like · 192 followers View post →
Ordo Fraterna Fibonacci
@OrdoFibonacci · X

Integrated-gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease | Communications Biology https://t.co/BRUI8Bw7rl

Apr 7, 2023 · 2 likes · 2,568 followers View post →
京都大学 平井研究室 / Hirai Lab., Kyoto Univ.
@mdde_kyoto · X

RT @iCeMS_KU: @ken1kamei @Eng_Kyoto_Univ 論文:“Integrated gut–liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty live…

Apr 7, 2023 · 1 share · 110 followers View post →
Ken-ichiro Kamei
@ken1kamei · X

RT @iCeMS_KU_INTL: @ken1kamei @Eng_Kyoto_Univ Paper “Integrated gut–liver-on-a-chip platform as an in vitro human model of non-alcoholic fa…

Apr 7, 2023 · 1 share · 469 followers View post →
iCeMS, Kyoto Univ - International
@iCeMS_KU_INTL · X

@ken1kamei @Eng_Kyoto_Univ Paper “Integrated gut–liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease” https://t.co/KYgWpYGkAX @CommsBio

Apr 7, 2023 · 3 likes · 1 share · 2,062 followers View post →
iCeMS, Kyoto Univ
@iCeMS_KU · X

@ken1kamei @Eng_Kyoto_Univ 論文:“Integrated gut–liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease” https://t.co/fRutFphd2W @CommsBio

Apr 7, 2023 · 2 likes · 1 share · 2,089 followers View post →
The Lipid Chronicles
@lipidchronicles · X

Integrated-gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease - Communications Biology https://t.co/xooYfW8QdK (@CommsBio)

Mar 31, 2023 · 4 likes · 1 share · 5,847 followers View post →
Science Advancement and Outreach
@SAOscience · X

New in @CommsBio from @ken1kamei & @KyotoU_News colleagues: "Integrated-gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease" https://t.co/8UL4a4pag8 #NAFLD #OOC #humanrelevantresearch

Mar 30, 2023 · 7 likes · 1,246 followers View post →
NMSLab Kyoto Univ
@NMSLabKyotoUniv · X

Paper Published. https://t.co/4f54EHREty

Mar 24, 2023 · 3 likes · 58 followers View post →
LUKMAN AFOLABI
@saintlukman · X

Integrated-gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease https://t.co/tK5hfKGdrR

Mar 23, 2023 · 1 like · 922 followers View post →
iCeMS, Kyoto Univ
@iCeMS_KU · X

RT @ken1kamei: We put our recent achievement in collaboration with Jiandong, Hirai sensei, and Iida sensei about Organs-on-a-Chip in bioRxi…

Jun 15, 2020 · 1 share · 2,089 followers View post →
CuMicrobioPapers
@BiolCopper · X

Integrated gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease https://t.co/queTzFU1C5

Jun 12, 2020 · 134 followers View post →
Ken-ichiro Kamei
@ken1kamei · X

We put our recent achievement in collaboration with Jiandong, Hirai sensei, and Iida sensei about Organs-on-a-Chip in bioRxiv! "Integrated gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease" #organsonachip #nafld https://t.co/wKnYRmHow1

Jun 12, 2020 · 6 likes · 1 share · 469 followers View post →
bioRxiv
@biorxivpreprint · X

Integrated gut-liver-on-a-chip platform as an in vitro human model of non-alcoholic fatty liver disease https://t.co/3gwyal7baV #bioRxiv

Jun 12, 2020 · 2 likes · 137,373 followers View post →