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Nat Commun March 2023 PMID 36973253

Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity.

Shuwen He, John P Gillies, Juliana L Zang, Carmen M Córdoba-Beldad, Io Yamamoto, Yasuhiro Fujiwara, Julie Grantham, Morgan E DeSantis, Hiroki Shibuya

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Mentions

4
Peak: 3 in Mar 2023
across 2 sources since Mar 2023

Extended reach

3,664
potential audience

Total likes

5

Video views

17

Mentions per month

Mar 2023 – Jul 2023

Where it's discussed

  • X / Twitter3 posts
  • YouTube1 videos

AI synopsis

What people are saying

The discussions show strong interest, exemplified by comments appreciating the detailed mechanisms revealed, especially the roles of DYNLRB1 and DYNLRB2 in spindle regulation. The tone is analytical but optimistic, emphasizing the importance of these complexes in cell division processes, which underscores the perceived impact of the study.

AgreementModerate agreement

Most discussions acknowledge the significance of the findings, with some explicitly expressing support for the research conclusions.

InterestHigh interest

Many comments highlight curiosity and enthusiasm about the mechanisms involving dynein complexes and spindle formation.

EngagementModerate engagement

Posts often reference specific parts of the study, such as the roles of DYNLRB2 in meiosis and how it prevents PCM fragmentation, indicating moderate in-depth engagement.

ImpactModerate impact

Reflecting on potential applications, some posts suggest this research could influence understanding of cell division disorders or fertility, indicating some perceived significance.

Abstract in brief

  • The study identifies two specific dynein complexes, one involving DYNLRB1 and the other involving DYNLRB2, that are crucial for spindle bipolarity in mitosis and male meiosis, respectively.
  • DYNLRB2 is essential in male meiosis for proper spindle formation; its absence causes arrest in metaphase I due to multipolar spindles and fragmented PCM, with DYNLRB2 acting to prevent PCM fragmentation through two pathways.
  • Both DYNLRB1 and DYNLRB2 dynein complexes target NuMA to regulate spindle formation, but they operate in separate pathways for mitotic and meiotic cell division.]
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Top posts

Most liked on X and Bluesky
Centrosome Papers
@CentrosomePub · X

Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity https://t.co/c0aF64W3bL

Mar 28, 2023 · 2 likes · 662 followers View post →
meiosispapers @meiosis_papers@mstdn.science
@meiosis_papers · X

Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity | Shuwen He | https://t.co/vY86bX4tHR

Mar 28, 2023 · 1 like · 1,579 followers View post →

All mentions

myosin actin crazy
@myosinactncrazy · X

Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity https://t.co/ASpJ3x7JFK

Mar 28, 2023 · 1 like · 1,407 followers View post →
meiosispapers @meiosis_papers@mstdn.science
@meiosis_papers · X

Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity | Shuwen He | https://t.co/vY86bX4tHR

Mar 28, 2023 · 1 like · 1,579 followers View post →
Centrosome Papers
@CentrosomePub · X

Distinct dynein complexes defined by DYNLRB1 and DYNLRB2 regulate mitotic and male meiotic spindle bipolarity https://t.co/c0aF64W3bL

Mar 28, 2023 · 2 likes · 662 followers View post →