Nat Commun March 2023 PMID 36973268

Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma.

Yige Wu, Nadezhda V Terekhanova, Wagma Caravan, Nataly Naser Al Deen, Preet Lal, Siqi Chen, Chia-Kuei Mo, Song Cao, Yize Li, Alla Karpova, Ruiyang Liu, Yanyan Zhao, Andrew Shinkle, Ilya Strunilin, Cody Weimholt

Download social card

Mentions

Peak: 8 in Mar 2023

across 3 sources since Mar 2023

Extended reach

50,895

potential audience

Total likes

Video views

Mentions per month

Mar 2023 – Jul 2023

Where it's discussed

X / Twitter12 posts
Facebook2 posts
YouTube1 videos

AI synopsis

What people are saying

The discussions reflect a positive reception, emphasizing the study’s contributions to understanding ccRCC progression, with mentions of 'markers,' 'pathways,' and insights into tumor heterogeneity. Words like 'characterization' and 'essential' convey its scientific depth, while references to institutions further underscore the perceived importance of the research.

AgreementModerate agreement

Most discussions acknowledge the importance of the research, with some expressing support or endorsement of the findings.

InterestHigh interest

The discussions demonstrate high curiosity, showing substantial focus on understanding the molecular mechanisms and clinical relevance.

EngagementModerate engagement

Posts reference specific scientific concepts and mention involved institutions, indicating meaningful engagement.

ImpactModerate impact

The topics discussed suggest an appreciation of the study’s significance within cancer research and potential therapies.

Abstract in brief

The study uses advanced genomic techniques to analyze tumor samples from patients with clear cell renal cell carcinoma (ccRCC), identifying 20 tumor-specific markers and linking higher ceruloplasmin (CP) expression to poorer survival, suggesting its role in tumor progression.
Spatial and single-cell analyses highlight tumor heterogeneity, suggesting that inflammation and epithelial-mesenchymal transition (EMT) are key features of different tumor cell subpopulations, impacting tumor behavior and interactions with the surrounding tissue.
The research also finds that mutations in specific genes like BAP1 and PBRM1 significantly alter chromatin accessibility, with BAP1 mutations leading to widespread chromatin reduction and PBRM1 mutations increasing accessibility, which helps clarify the molecular mechanisms driving ccRCC development.]

Read the full abstract

All mentions

Epigenetic and Transcriptomic Markers in Clear Cell Renal Cell Carcinoma

This study utilizes advanced genomic techniques to analyze ccRCC tumor samples, identifying progression markers and pathways. Higher ceruloplasmin levels are linked to poorer survival, with tumor heterogeneity and key…

STEM RTCL TV · Jul 30, 2023 30 views

Manojit Swamynathan

@manojit_ms · X

RT @FrezzaLab: Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell c…

Apr 2, 2023 · 3 shares · 478 followers View post →

Heer Lab

@Heer_Lab · X

RT @FrezzaLab: Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell c…

Apr 2, 2023 · 3 shares · 1,617 followers View post →

Dr. Brad Reinfeld, MD PhD

@BReinfeld · X

RT @FrezzaLab: Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell c…

Apr 2, 2023 · 3 shares · 1,420 followers View post →

FrezzaLab

@FrezzaLab · X

Epigenetic and transcriptomic characterization reveals progression markers and essential pathways in clear cell renal cell carcinoma | Nature Communications https://t.co/G4j25KRCD5

Apr 2, 2023 · 13 likes · 3 shares · 26,994 followers View post →

Ben Humphreys

@HumphreysLab · X