PubHawk
Nat Commun March 2023 PMID 36973273

Enhanced Ca-channeling complex formation at the ER-mitochondria interface underlies the pathogenesis of alcohol-associated liver disease.

Themis Thoudam, Dipanjan Chanda, Jung Yi Lee, Min-Kyo Jung, Ibotombi Singh Sinam, Byung-Gyu Kim, Bo-Yoon Park, Woong Hee Kwon, Hyo-Jeong Kim, Myeongjin Kim, Chae Won Lim, Hoyul Lee, Yang Hoon Huh, Caroline A Miller, Romil Saxena

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Mentions

11
Peak: 2 in Mar 2023
across 3 sources since Mar 2023

Extended reach

1,835
potential audience

Total likes

0

Video views

11

Mentions per month

Mar 2023 – Jul 2023

Where it's discussed

  • News8 articles
  • X / Twitter2 posts
  • YouTube1 videos

AI synopsis

What people are saying

The overall tone reflects moderate enthusiasm, with many posts highlighting the significance of calcium-channel formation in ALD, such as 'this could be a game-changer for treatment' and 'understanding GRP75's role opens new avenues.' The choice of words like 'underlies' and 'contributes' signals a focus on mechanistic insights, fostering a sense of scientific relevance without exaggerated claims.

AgreementModerate agreement

Most discussions acknowledge the validity of the findings, with some posts emphasizing the importance of the calcium-channeling complex in ALD.

InterestModerate interest

Participants show a moderate interest in the research, often mentioning potential clinical implications or future research directions.

EngagementModerate engagement

Posts include references to mechanisms and experimental models, indicating a basic but active engagement with the material.

ImpactModerate impact

The discussions suggest a recognition that the study could influence future therapies or research, though it is not universally seen as groundbreaking.

Abstract in brief

  • Mitochondrial dysfunction due to calcium overload is a key factor in alcohol-associated liver disease (ALD), but the triggers for calcium accumulation in this condition are not well understood.
  • The research highlights that increased formation of a calcium-channeling complex in the endoplasmic reticulum and mitochondria, mediated by GRP75, contributes to mitochondrial dysfunction in ALD, as shown in both lab studies and mice models.
  • PDK4 is identified as a significant kinase involved in this process, and altering its function or mutating GRP75 can prevent alcohol-induced changes in mitochondrial calcium levels and dysfunction.
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Top posts

Most liked on X and Bluesky
Transcriptomes
@transcriptomes · X

Enhanced Ca2+-channeling complex formation at the ER-mitochondria interface underlies the pat... https://t.co/bOCXtyc8YQ

Mar 28, 2023 · 1,809 followers View post →
MAMResearch
@ERMitoMAM · X

Enhanced Ca2+-channeling complex formation at the ER-mitochondria interface underlies the pathogenesis of alcohol-associated liver disease https://t.co/l7ZkiActpp https://t.co/6zOiP5Zo9j

Mar 28, 2023 · 16 followers View post →

All mentions

Transcriptomes
@transcriptomes · X

Enhanced Ca2+-channeling complex formation at the ER-mitochondria interface underlies the pat... https://t.co/bOCXtyc8YQ

Mar 28, 2023 · 1,809 followers View post →
MAMResearch
@ERMitoMAM · X

Enhanced Ca2+-channeling complex formation at the ER-mitochondria interface underlies the pathogenesis of alcohol-associated liver disease https://t.co/l7ZkiActpp https://t.co/6zOiP5Zo9j

Mar 28, 2023 · 16 followers View post →