J Extracell Vesicles April 2023 PMID 36973758

The glycoprotein CD147 defines miRNA-enriched extracellular vesicles that derive from cancer cells.

Song Yi Ko, WonJae Lee, Melanie Weigert, Eric Jonasch, Ernst Lengyel, Honami Naora

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Mentions

Peak: 2 in Oct 2023

across 3 sources since Mar 2023

Extended reach

8,095

potential audience

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Mar 2023 – Oct 2023

Where it's discussed

News4 articles
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What people are saying

Participants express strong interest by highlighting the role of CD147 in enriching cancer EVs, referring to upcoming meetings and encouraging further reading. The tone conveys enthusiasm about the clinical implications, especially with phrases like 'significant potential' and 'key discovery,' which underscore the research's importance and relevance in advancing cancer diagnostics.

AgreementModerate agreement

Most discussions acknowledge the significance of CD147 in identifying cancer-derived EVs, indicating general agreement on its potential utility.

InterestHigh interest

Participants show high curiosity and enthusiasm, especially with mentions of specific markers like CD147 and miRNA enrichment.

EngagementModerate engagement

Posts reference events like EVClub meetings and emphasize the importance of the findings, demonstrating moderate active engagement.

ImpactHigh impact

The discussions highlight the potential for this research to advance liquid biopsy techniques, suggesting a strong perceived impact on cancer diagnosis.

Abstract in brief

Extracellular vesicles (EVs) are promising candidates for liquid biopsy, but differentiating cancer cell-derived EVs from other types has been difficult.
Researchers discovered that the glycoproteins CD147 and CD98 can identify specific EV subpopulations with CD147 EVs showing higher microRNA (miRNA) content and a clear association with cancer cells.
In clinical studies, circulating CD147 EVs were found to be significantly elevated in ovarian and renal cancer patients compared to healthy individuals, suggesting that CD147 could serve as a useful target for isolating cancer-related miRNAs, enhancing liquid biopsy techniques.

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All mentions

CD147 Glycoprotein Identifies Cancer-Derived Extracellular Vesicles for Liquid Biopsy Enhancement

Extracellular vesicles are promising for liquid biopsy, but distinguishing cancer cell-derived EVs is challenging. This study shows that the glycoprotein CD147 defines miRNA-enriched EVs from cancer cells, with…

Social RTCL TV · Aug 4, 2023 47 views

Abdulwahab Teflischi

@Hoobie66751442 · X

RT @KennethWWitwer: Next #EVClub is with Honami Naora: CD147 defines #miRNA-enriched cancer #ExtracellularVesicles Wed 18 Oct 12 noon EDT/1…

Oct 18, 2023 · 1 share · 77 followers View post →

Kenneth W Witwer (he/him)

@KennethWWitwer · X

Oct 14, 2023 · 8 likes · 1 share · 4,986 followers View post →

ISEV-Journals

@ISEV_Journals · X

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Mar 29, 2023 · 1 like · 2,982 followers View post →