Nat Commun March 2023 PMID 36977663

Arabidopsis TRB proteins function in H3K4me3 demethylation by recruiting JMJ14.

Ming Wang, Zhenhui Zhong, Javier Gallego-Bartolomé, Suhua Feng, Yuan-Hsin Shih, Mukun Liu, Jessica Zhou, John Curtis Richey, Charmaine Ng, Yasaman Jami-Alahmadi, James Wohlschlegel, Keqiang Wu, Steven E Jacobsen

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Peak: 4 in Jan 2023

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Several contributions highlight the significance of the TRB proteins' role in H3K4me3 demethylation and gene regulation, such as noting the recruitment of JMJ14 or the implications for epigenetic control, using words like 'function' and 'demethylation' to emphasize scientific importance. The tone is generally neutral or mildly enthusiastic, reflecting a curiosity-driven but cautious perception of the research's impact.

AgreementModerate agreement

The discussions mostly acknowledge the findings, with some expressing enthusiasm about the role of TRB proteins in epigenetic regulation.

InterestModerate interest

Participants show moderate interest, reflecting curiosity about the mechanisms of gene regulation in Arabidopsis.

EngagementNeutral engagement

There is limited depth of engagement, with mostly repeated references to the publication without detailed analysis.

ImpactModerate impact

The shared discussions suggest the publication may influence future research directions, but overall perceived moderate impact.

Abstract in brief

Arabidopsis telomeric repeat binding factors (TRBs) protect telomeres and recruit PRC2 to add H3K27me3 marks on certain genes.
TRBs also work with JUMONJI14 (JMJ14) to remove H3K4me3 methylation at specific locations, which increases the expression of their target genes in certain mutants.
Using an artificial zinc finger to attach TRBs to gene promoters leads to gene silencing by promoting H3K27me3 deposition and removing H3K4me3, highlighting a coordinated role of TRBs in gene repression through these epigenetic modifications.

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Arabidopsis TRB Proteins in Epigenetic Gene Regulation

Arabidopsis telomeric repeat binding factors protect telomeres and recruit PRC2 to modify histones. They also work with JMJ14 to remove H3K4me3 methylation, increasing target gene expression and influencing epigenetic…

STEM RTCL TV · Jul 18, 2023 9 views

Taiji Kawakatsu

@Kawakatsu_Lab · X

RT @biorxiv_plants: Arabidopsis TRB proteins function in H3K4me3 demethylation by recruiting JMJ14 https://t.co/HOih8gRkTS #biorxiv_plants

Jan 11, 2023 · 2 shares · 360 followers View post →

Eduardo Mateo / @emateobonmati.bsky.social

@emateobonmati · X

RT @biorxiv_plants: Arabidopsis TRB proteins function in H3K4me3 demethylation by recruiting JMJ14 https://t.co/HOih8gRkTS #biorxiv_plants

Jan 11, 2023 · 2 shares · 629 followers View post →

bioRxiv Plant Bio

@biorxiv_plants · X

Arabidopsis TRB proteins function in H3K4me3 demethylation by recruiting JMJ14 https://t.co/HOih8gRkTS #biorxiv_plants

Jan 11, 2023 · 8 likes · 2 shares · 15,847 followers View post →

bioRxiv

@biorxivpreprint · X

Arabidopsis TRB proteins function in H3K4me3 demethylation by recruiting JMJ14 https://t.co/fc94ZigPrE #bioRxiv

Jan 11, 2023 · 1 like · 136,932 followers View post →