J Nanobiotechnology March 2023 PMID 36978078

BBB-on-a-chip with integrated micro-TEER for permeability evaluation of multi-functionalized gold nanorods against Alzheimer's disease.

Sujey Palma-Florez, Adrián López-Canosa, Francisco Moralez-Zavala, Oscar Castaño, Marcelo J Kogan, Josep Samitier, Anna Lagunas, Mònica Mir

Full text PDF Download social card

Mentions

Peak: 11 in Mar 2023

across 3 sources since Sep 2022

Extended reach

189,980

potential audience

Total likes

Video views

Mentions per month

Sep 2022 – May 2024

Where it's discussed

X / Twitter23 posts
News9 articles
YouTube1 videos

AI synopsis

What people are saying

The discussions consistently praise the innovative BBB-on-a-chip platform and its potential to revolutionize Alzheimer's research, as evidenced by comments mentioning the device's ability to mimic the human neurovascular environment and its selection as a top article of the year. The tone is largely enthusiastic and supportive, reflecting a shared excitement about the technological and medical impact of this study.

AgreementStrong agreement

The majority of discussions express strong support and excitement for the advances in Alzheimer's research and the technical innovations of the BBB-on-a-chip platform.

InterestHigh interest

There is high interest, as reflected in enthusiastic comments, awards received, and sharing across multiple platforms, indicating a strong appeal within the scientific community.

EngagementModerate engagement

Most posts include detailed mentions of methodology and implications, with some participants actively sharing praise and explaining the significance of the research.

ImpactHigh impact

The discussions highlight that this research could significantly impact drug testing and neurodegenerative disease treatment, emphasizing its potential for animal-free, more accurate models.

Abstract in brief

The study introduces a novel BBB-on-a-chip platform with integrated TEER measurement, allowing for more accurate, animal-free testing of drug permeability and effects on the blood-brain barrier, specifically focusing on Alzheimer's disease.
Researchers developed and tested a special gold nanorod-based nanosystem (GNRPEGAng2D1) designed to cross the BBB and inhibit amyloid fibrillation, showing positive results in terms of safety (non-cytotoxicity) and permeability using the new chip.
The BBB-on-a-chip mimics key features of the human neurovascular environment, including tight junctions and a neurovascular network, providing a versatile, reproducible alternative to animal models for evaluating drug delivery systems for neurodegenerative diseases.]

Read the full abstract

All mentions

Innovative BBB-on-a-chip with TEER for Alzheimer's Drug Testing

This study introduces a novel BBB-on-a-chip platform with integrated TEER measurement, enabling accurate, animal-free testing of drug permeability and effects on the blood-brain barrier. It focuses on evaluating…

STEM RTCL TV · Jul 21, 2023 32 views

Michelle Buenrostro

@Mrs_Buenrostro_ · X

RT @IBECBarcelona: @UniBarcelona @UBDivulga @samitierjosep @PCB_UB @_BIST @iCERCA @CIBERBBN @uchile @FONDAP_ACCDiS @oscar_castano

May 23, 2024 · 3 shares · 22 followers View post →

IBEC

@IBECBarcelona · X

May 17, 2024 · 6 likes · 9,335 followers View post →

Oscar @oscar_castano@mstdn.social

@oscar_castano · X

RT @anna_jolene1: Very happy that our paper “BBB-on-a-chip with integrated micro-TEER for permeability evaluation of multi-functionalized g…

Apr 19, 2024 · 1 share · 165 followers View post →

Anna Lagunas

@anna_jolene1 · X

Apr 19, 2024 · 9 likes · 1 share · 204 followers View post →

IBEC

@IBECBarcelona · X

RT @SAOscience: .@anna_jolene1 and team at @IBECBarcelona are changing Alzheimer’s research by developing an #OoC to test the brain

Nov 14, 2023 · 3 shares · 9,335 followers View post →

FRESCI

@FRE_SCI · X

RT @SAOscience: .@anna_jolene1 and team at @IBECBarcelona are changing Alzheimer’s research by developing an #OoC to test the brain

Nov 14, 2023 · 3 shares · 261 followers View post →

Anna Lagunas

@anna_jolene1 · X

RT @SAOscience: .@anna_jolene1 and team at @IBECBarcelona are changing Alzheimer’s research by developing an #OoC to test the brain

Nov 13, 2023 · 3 shares · 204 followers View post →

Science Advancement and Outreach

@SAOscience · X

.@anna_jolene1 and team at @IBECBarcelona are changing Alzheimer’s research by developing an #OoC to test the brain

Nov 13, 2023 · 13 likes · 3 shares · 1,246 followers View post →

Journal of Nanobiotechnology

@JNanobiotech · X

RT @IBECBarcelona: @UniBarcelona @UBDivulga @samitierjosep @PCB_UB @_BIST @iCERCA @CIBERBBN @uchile @FONDAP_ACCDiS @oscar_castano

May 4, 2023 · 3 shares · 423 followers View post →

Josep Samitier

@samitierjosep · X

RT @IBECBarcelona: @UniBarcelona @UBDivulga @samitierjosep @PCB_UB @_BIST @iCERCA @CIBERBBN @uchile @FONDAP_ACCDiS @oscar_castano

Mar 30, 2023 · 3 shares · 651 followers View post →

IBEC

@IBECBarcelona · X

@UniBarcelona @UBDivulga @samitierjosep @PCB_UB @_BIST @iCERCA @CIBERBBN @uchile @FONDAP_ACCDiS @oscar_castano

Mar 30, 2023 · 4 likes · 3 shares · 9,335 followers View post →

Hammed Onilude (PhD)

@HammedOnilude · X

BBB-on-a-chip with integrated micro-TEER for permeability evaluation of multi-functionalized gold nanorods against Alzheimer’s disease https://t.co/BaEyLsDjlw

Mar 29, 2023 · 296 followers View post →

@Celestetoston

@celestetoston · X

RT @Investiga_SEA: Un estudio liderado por el Instituto de Bioingeniería de Cataluña (IBEC) describe el desarrollo de un órgano-en-un-chip…

Mar 29, 2023 · 3 shares · 509 followers View post →

Federacion Española de Proteccion Animal

@FEPAnimal · X

RT @Investiga_SEA: Un estudio liderado por el Instituto de Bioingeniería de Cataluña (IBEC) describe el desarrollo de un órgano-en-un-chip…

Mar 29, 2023 · 3 shares · 2,335 followers View post →

morris salswach

@morris_salswach · X

RT @Investiga_SEA: Un estudio liderado por el Instituto de Bioingeniería de Cataluña (IBEC) describe el desarrollo de un órgano-en-un-chip…

Mar 29, 2023 · 3 shares · 4,955 followers View post →

SinExperimentacionAnimal

@Investiga_SEA · X

Un estudio liderado por el Instituto de Bioingeniería de Cataluña (IBEC) describe el desarrollo de un órgano-en-un-chip del cerebro que funciona como modelo de la barrera hematoencefálica humana que permite estudiar fármacos contra el #Alzheimer https://t.co/6Ycnb1E9p2

Mar 29, 2023 · 3 likes · 3 shares · 779 followers View post →

IBEC

@IBECBarcelona · X

@UniBarcelona @CIBERBBN @PCB_UB @_BIST @iCERCA @samitierjosep @uchile @FONDAP_ACCDiS

Mar 29, 2023 · 2 likes · 9,335 followers View post →

Anna Lagunas

@anna_jolene1 · X

Mar 29, 2023 · 9 likes · 204 followers View post →

iBraiN Inserm Lab

@iBrain_Inserm · X

RT @bbbpapers: BBB-on-a-chip with integrated micro-TEER for permeability evaluation of multi-functionalized gold nanorods against Alzheimer…

Mar 29, 2023 · 1 share · 1,722 followers View post →

Blood brain barrier

@bbbpapers · X

BBB-on-a-chip with integrated micro-TEER for permeability evaluation of multi-functionalized gold nanorods against Alzheimer's disease https://t.co/HZUOvBvWQy

Mar 29, 2023 · 1 like · 1 share · 774 followers View post →

Anna Lagunas

@anna_jolene1 · X

Our preprint on BBB-oC with integrated TEER analysis for the study of drug efficacy is out

Sep 7, 2022 · 8 likes · 204 followers View post →

bioRxiv Bioengineering

@bioRxiv_bioE · X

BBB-on-a-chip with Integrated micro-TEER for permeability evaluation of multi-functionalized gold nanorods against Alzheimer's disease https://t.co/TJ0uppkPmp #biorxiv_bioE

Sep 6, 2022 · 208 followers View post →

bioRxiv

@biorxivpreprint · X

BBB-on-a-chip with Integrated micro-TEER for permeability evaluation of multi-functionalized gold nanorods against Alzheimer's disease https://t.co/viE2vOVtUa #bioRxiv

Sep 6, 2022 · 137,367 followers View post →

BBB-on-a-chip with integrated micro-TEER for permeability evaluation of multi-functionalized gold nanorods against Alzheimer's disease.

Mentions per month

Where it's discussed

What people are saying

Abstract in brief

Top posts

All mentions

Innovative BBB-on-a-chip with TEER for Alzheimer's Drug Testing