ACS Chem Biol April 2023 PMID 36988910

Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity.

Cyrielle Billon, Sadichha Sitaula, Subhashis Banerjee, Ryan Welch, Bahaa Elgendy, Lamees Hegazy, Tae Gyu Oh, Melissa Kazantzis, Arindam Chatterjee, John Chrivia, Matthew E Hayes, Weiyi Xu, Angelica Hamilton, Janice M Huss, Lilei Zhang

Mentions

139
Peak: 12 in Sep 2023
across 5 sources since Mar 2023

Extended reach

1,286,261
potential audience

Total likes

549

Video views

22,779

Mentions per month

Mar 2023 – Jul 2025

Where it's discussed

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  • Facebook2 posts

AI synopsis

What people are saying

The overall tone reveals strong enthusiasm and interest, supported by phrases like 'coolest out-of-field paper' and 'potential for function-promoting therapeutics,' which demonstrate excitement and perceived high impact. Engagement is evident through detailed mentions of muscle remodeling and exercise mimetics, indicating deep engagement with the research's implications.

AgreementStrong agreement

Most discussions express enthusiasm, seeing the research as promising or groundbreaking, such as calling it 'the coolest out-of-field paper' and highlighting its potential in performance enhancement.

InterestHigh interest

Posts show high curiosity and fascination, with comments like 'very intrigued' and noting potential applications beyond basic science.

EngagementHigh engagement

Numerous discussions delve into methodological implications and future uses, including mentions of muscle remodeling and exercise mimetics, showing active analysis.

ImpactHigh impact

Posts imply this research could significantly influence fields like metabolic disease treatment and sports performance, describing it as 'game changing' and mentioning 'potential therapeutics.'

Top posts

Most liked on X and Bluesky
NARKAR LAB - Exercise, Muscle & Vascular Medicine
@LabNarkar · X

Tom Burris lab along with Ron Evans and colleagues report on a new estrogen-related receptor pan-agonist that drives muscle remodeling and exercise endurance! Potential for function-promoting therapeutics in muscle diseases.... https://t.co/IwN1v3GNz5

Apr 2, 2023 · 27 likes · 5 shares · 193 followers View post →
Medical Xpress
@medical_xpress · X

Exercise-mimicking #drug sheds weight, boosts muscle activity in #mice @ChemicalBiology https://t.co/O7wKlNDuIG https://t.co/KJVAmLCMYJ

Sep 25, 2023 · 19 likes · 10 shares · 173,280 followers View post →
Agingdoc
@agingdoc1 · X

Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity https://t.co/KovPsC6M8R https://t.co/mfjv6yb2pv

Sep 26, 2023 · 7 likes · 1 share · 42,353 followers View post →
Marc Chevrette
@wildtypeMC · X

This might be the coolest out-of-my-field paper I've read in years, possibly ever. SLU-PP-332 looks amazing as a possible treatment for metabolic disease and, maybe more interestingly, as performance enhancing drug. Very intrigued. https://t.co/VehI2DBnE6

Dec 31, 2024 · 7 likes · 3,357 followers View post →
Alex Moloney
@MoloneyAlex · X

Small molecules acting as exercise mimetics! I would have strongly supported calling this compound Exercizine https://t.co/5x25laTrWj

Mar 30, 2023 · 3 likes · 343 followers View post →
Walter Suárez Carmona
@a_fisiolog57853 · X

- Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity (Billion et al., 2023) https://t.co/RCNEJgt89E

Mar 21, 2024 · 1 like · 4,131 followers View post →

All mentions

Marc Chevrette
@wildtypeMC · X

This might be the coolest out-of-my-field paper I've read in years, possibly ever. SLU-PP-332 looks amazing as a possible treatment for metabolic disease and, maybe more interestingly, as performance enhancing drug. Very intrigued. https://t.co/VehI2DBnE6

Dec 31, 2024 · 7 likes · 3,357 followers View post →
trainerrueben
@trainerrueben · X

https://t.co/VSwU6ur3zD

Jul 15, 2024 · 953 followers View post →
trainerrueben
@trainerrueben · X

Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity Cyrielle Billon et al. ACS Chem Biol. 2023. https://t.co/z9YrWPVBYs

Jul 15, 2024 · 953 followers View post →
Walter Suárez Carmona
@a_fisiolog57853 · X

- Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity (Billion et al., 2023) https://t.co/RCNEJgt89E

Mar 21, 2024 · 1 like · 4,131 followers View post →
サイエンスあれこれ
@sarekore · X

SLU-PP-332を投与された正常体重のマウスは、投与されていないマウスよりも70%長く、45%遠くまで走れることが確認されました。そして、今回、SLU-PP-332を肥満マウスに1日2回、1ヵ月間投与したところ、このマウスは、未投与のマウスと同じ量の餌を食べ、運動もしなかったにもhttps://t.co/GK0FrBnz3t

Oct 15, 2023 · 930 followers View post →
Mind Your Science!
@MindYourSci · X

RT @agingdoc1: Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity https:/…

Oct 2, 2023 · 1 share · 132 followers View post →
NP AGARWAL世界一フォローを目指しますAiming best in world.
@np_grwl · X

RT @medical_xpress: Exercise-mimicking #drug sheds weight, boosts muscle activity in #mice @ChemicalBiology https://t.co/O7wKlNDuIG https:/…

Sep 27, 2023 · 10 shares · 1,789 followers View post →
darcy darnoc
@darcydarnoc · X

Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity - PubMed https://t.co/BFV2V9AE1W

Sep 26, 2023 · 3,126 followers View post →
Agingdoc
@agingdoc1 · X

Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity https://t.co/KovPsC6M8R https://t.co/mfjv6yb2pv

Sep 26, 2023 · 7 likes · 1 share · 42,353 followers View post →
Stefan W
@StefanW54906562 · X

RT @medical_xpress: Exercise-mimicking #drug sheds weight, boosts muscle activity in #mice @ChemicalBiology https://t.co/O7wKlNDuIG https:/…

Sep 26, 2023 · 10 shares · 486 followers View post →
Phenomics
@Phenomics_J · X

RT @medical_xpress: Exercise-mimicking #drug sheds weight, boosts muscle activity in #mice @ChemicalBiology https://t.co/O7wKlNDuIG https:/…

Sep 26, 2023 · 10 shares · 1,524 followers View post →
Manoj Mayogi Mishra
@mayogisense · X

RT @medical_xpress: Exercise-mimicking #drug sheds weight, boosts muscle activity in #mice @ChemicalBiology https://t.co/O7wKlNDuIG https:/…

Sep 25, 2023 · 10 shares · 574 followers View post →
Abelus
@abelusmx · X

RT @medical_xpress: Exercise-mimicking #drug sheds weight, boosts muscle activity in #mice @ChemicalBiology https://t.co/O7wKlNDuIG https:/…

Sep 25, 2023 · 10 shares · 381 followers View post →
serrgv
@serrgv · X

RT @medical_xpress: Exercise-mimicking #drug sheds weight, boosts muscle activity in #mice @ChemicalBiology https://t.co/O7wKlNDuIG https:/…

Sep 25, 2023 · 10 shares · 145 followers View post →
miljan bojović
@miljanbojo · X

RT @medical_xpress: Exercise-mimicking #drug sheds weight, boosts muscle activity in #mice @ChemicalBiology https://t.co/O7wKlNDuIG https:/…

Sep 25, 2023 · 10 shares · 1,895 followers View post →
Science X
@sciencex_com · X

RT @medical_xpress: Exercise-mimicking #drug sheds weight, boosts muscle activity in #mice @ChemicalBiology https://t.co/O7wKlNDuIG https:/…

Sep 25, 2023 · 10 shares · 3,532 followers View post →
Phys.org
@physorg_com · X

RT @medical_xpress: Exercise-mimicking #drug sheds weight, boosts muscle activity in #mice @ChemicalBiology https://t.co/O7wKlNDuIG https:/…

Sep 25, 2023 · 10 shares · 1,022,452 followers View post →
Medical Xpress
@medical_xpress · X

Exercise-mimicking #drug sheds weight, boosts muscle activity in #mice @ChemicalBiology https://t.co/O7wKlNDuIG https://t.co/KJVAmLCMYJ

Sep 25, 2023 · 19 likes · 10 shares · 173,280 followers View post →
lbgbox
@lbgbox · X

RT @LabNarkar: Tom Burris lab along with Ron Evans and colleagues report on a new estrogen-related receptor pan-agonist that drives muscle…

Apr 3, 2023 · 5 shares · 52 followers View post →
Luiz Romeiro
@lasromeiro · X

RT @LabNarkar: Tom Burris lab along with Ron Evans and colleagues report on a new estrogen-related receptor pan-agonist that drives muscle…

Apr 2, 2023 · 5 shares · 183 followers View post →
André Katayama Yamada
@KatayamaYamada · X

RT @LabNarkar: Tom Burris lab along with Ron Evans and colleagues report on a new estrogen-related receptor pan-agonist that drives muscle…

Apr 2, 2023 · 5 shares · 402 followers View post →
Hec
@Muscles_n_Mitos · X

RT @LabNarkar: Tom Burris lab along with Ron Evans and colleagues report on a new estrogen-related receptor pan-agonist that drives muscle…

Apr 2, 2023 · 5 shares · 62 followers View post →
NARKAR LAB - Exercise, Muscle & Vascular Medicine
@LabNarkar · X

Tom Burris lab along with Ron Evans and colleagues report on a new estrogen-related receptor pan-agonist that drives muscle remodeling and exercise endurance! Potential for function-promoting therapeutics in muscle diseases.... https://t.co/IwN1v3GNz5

Apr 2, 2023 · 27 likes · 5 shares · 193 followers View post →
Alex Moloney
@MoloneyAlex · X

Small molecules acting as exercise mimetics! I would have strongly supported calling this compound Exercizine https://t.co/5x25laTrWj

Mar 30, 2023 · 3 likes · 343 followers View post →