Nat Commun March 2023 PMID 36990995

Self assembling nanoparticle enzyme clusters provide access to substrate channeling in multienzymatic cascades.

Joyce C Breger, James N Vranish, Eunkeu Oh, Michael H Stewart, Kimihiro Susumu, Guillermo Lasarte-Aragonés, Gregory A Ellis, Scott A Walper, Sebastián A Díaz, Shelby L Hooe, William P Klein, Meghna Thakur, Mario G Ancona, Igor L Medintz

Mentions

10
Peak: 5 in Mar 2023
across 3 sources since Mar 2023

Extended reach

4,890
potential audience

Total likes

6

Video views

27

Mentions per month

Mar 2023 – Jul 2023

Where it's discussed

  • X / Twitter7 posts
  • Blogs2 articles
  • YouTube1 videos

AI synopsis

What people are saying

The collection of discussions revolves around the core idea that nanoparticle enzyme clusters enable substrate channeling, with repeated references to its benefits in catalysis and synthetic biology. Words like 'provide access' and hashtags like '#DTH' suggest a focus on highlighting the technique's novelty and potential, though the tone remains generally supportive and straightforward without extensive analysis.

AgreementModerate agreement

Most discussions acknowledge and support the significance of the research, often echoing its potential benefits.

InterestModerate interest

Participants show a moderate level of curiosity, primarily through recognition rather than detailed critique or exploration.

EngagementNeutral engagement

The posts tend to be brief and repetitive, indicating some acknowledgment but limited in-depth dialogue.

ImpactModerate impact

The discussions emphasize the promising nature of the work and imply it holds meaningful scientific potential.

Abstract in brief

  • This study shows that enzymes in a cascade can self-assemble on nanoparticle scaffolds, creating nanoclusters that significantly enhance substrate channeling and catalytic efficiency.
  • By optimizing factors like enzyme proportion, nanoparticle shape, and enzyme arrangement, the researchers achieved several-fold improvements in enzyme performance for complex biocatalytic processes.
  • The approach is versatile and can be extended to different types of nanoparticles, offering promising advances for building minimal cell-free systems in synthetic biology.

Top posts

Most liked on X and Bluesky
Ryo Yokoyama
@yokoyama_ryo · X

Self assembling nanoparticle enzyme clusters provide access to substrate channeling in multienzymatic cascades https://t.co/GXTfXuXh0N @NatureComms

Mar 30, 2023 · 6 likes · 3 shares · 1,934 followers View post →
Juan Camilo Moreno Beltran
@JuanCa_rotenoid · X

RT @yokoyama_ryo: Self assembling nanoparticle enzyme clusters provide access to substrate channeling in multienzymatic cascades https://t.…

Mar 30, 2023 · 3 shares · 937 followers View post →
Guillermo Lasarte #SinCienciaNOhayFuturo
@LasarteG · X

RT @yokoyama_ryo: Self assembling nanoparticle enzyme clusters provide access to substrate channeling in multienzymatic cascades https://t.…

Apr 18, 2023 · 3 shares · 472 followers View post →
Guillermo Lasarte #SinCienciaNOhayFuturo
@LasarteG · X

RT @CDADeathStar: Self assembling nanoparticle enzyme clusters provide access to substrate channeling in null https://t.co/1cDhKQbhfW #DTH…

Apr 1, 2023 · 1 share · 472 followers View post →
Guillermo Lasarte #SinCienciaNOhayFuturo
@LasarteG · X

RT @EKL_Batteries: Self assembling nanoparticle enzyme clusters provide access to substrate channeling in multienzymatic cascades https://t…

Mar 30, 2023 · 1 share · 472 followers View post →
EKL_Batteries
@EKL_Batteries · X

Self assembling nanoparticle enzyme clusters provide access to substrate channeling in multienzymatic cascades https://t.co/b0ZoNKYr55

Mar 30, 2023 · 1 share · 437 followers View post →

All mentions

Guillermo Lasarte #SinCienciaNOhayFuturo
@LasarteG · X

RT @yokoyama_ryo: Self assembling nanoparticle enzyme clusters provide access to substrate channeling in multienzymatic cascades https://t.…

Apr 18, 2023 · 3 shares · 472 followers View post →
Guillermo Lasarte #SinCienciaNOhayFuturo
@LasarteG · X

RT @CDADeathStar: Self assembling nanoparticle enzyme clusters provide access to substrate channeling in null https://t.co/1cDhKQbhfW #DTH…

Apr 1, 2023 · 1 share · 472 followers View post →
DTHSTR
@CDADeathStar · X

Self assembling nanoparticle enzyme clusters provide access to substrate channeling in null https://t.co/1cDhKQbhfW #DTHSTR

Mar 30, 2023 · 1 share · 113 followers View post →
Juan Camilo Moreno Beltran
@JuanCa_rotenoid · X

RT @yokoyama_ryo: Self assembling nanoparticle enzyme clusters provide access to substrate channeling in multienzymatic cascades https://t.…

Mar 30, 2023 · 3 shares · 937 followers View post →
Ryo Yokoyama
@yokoyama_ryo · X

Self assembling nanoparticle enzyme clusters provide access to substrate channeling in multienzymatic cascades https://t.co/GXTfXuXh0N @NatureComms

Mar 30, 2023 · 6 likes · 3 shares · 1,934 followers View post →
Guillermo Lasarte #SinCienciaNOhayFuturo
@LasarteG · X

RT @EKL_Batteries: Self assembling nanoparticle enzyme clusters provide access to substrate channeling in multienzymatic cascades https://t…

Mar 30, 2023 · 1 share · 472 followers View post →
EKL_Batteries
@EKL_Batteries · X

Self assembling nanoparticle enzyme clusters provide access to substrate channeling in multienzymatic cascades https://t.co/b0ZoNKYr55

Mar 30, 2023 · 1 share · 437 followers View post →