Commun Biol March 2023 PMID 36997603

DDX3Y is likely the key spermatogenic factor in the AZFa region that contributes to human non-obstructive azoospermia.

Ann-Kristin Dicke, Adrian Pilatz, Margot J Wyrwoll, Margus Punab, Christian Ruckert, Liina Nagirnaja, Kenneth I Aston, Donald F Conrad, Sara Di Persio, Nina Neuhaus, Daniela Fietz, Maris Laan, Birgit Stallmeyer, Frank Tüttelmann

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Mentions

5
Peak: 2 in Apr 2023
across 2 sources since Mar 2023

Extended reach

4,353
potential audience

Total likes

0

Video views

29

Mentions per month

Mar 2023 – Aug 2023

Where it's discussed

  • X / Twitter4 posts
  • YouTube1 videos

AI synopsis

What people are saying

The discussions reflect a high level of agreement and interest, emphasizing the importance of DDX3Y in spermatogenesis and male infertility. Phrases like 'key gene' and mentions of genetic screening highlight the perceived importance, while references to funding and research context show engagement with the scientific process. The tone suggests that these findings could significantly influence future diagnostic approaches.

AgreementStrong agreement

Most discussions strongly agree with the publication's conclusion that DDX3Y is a key gene in spermatogenesis and male infertility, reinforcing its importance in the field.

InterestHigh interest

Highlighting the gene's role and potential for genetic screening demonstrates high interest among the audience interested in reproductive genetics.

EngagementModerate engagement

Several discussions delve into implications for diagnosis and treatment, indicating thoughtful engagement, although some comments are more superficial.

ImpactHigh impact

The consensus suggests significant impact, as the findings may influence future diagnostic practices and understanding of male infertility.

Abstract in brief

  • DDX3Y is identified as the crucial gene in the AZFa region responsible for human nonobstructive azoospermia, a severe male infertility condition caused by disrupted spermatogenesis.
  • Four likely pathogenic loss-of-function variants in DDX3Y were found in over 1600 infertile men, with some patients showing a Sertoli cell-only testicular phenotype and one variant being de novo.
  • The findings suggest that DDX3Y is the key gene for germ cell development in the AZFa region, and genetic screening for DDX3Y variants should be part of the infertility diagnostic process.]

Top posts

Most liked on X and Bluesky
Stigmabase | ORG
@StigmabaseO · X

TW : DDX3Y is likely the key spermatogenic factor in the AZFa region that contributes to human...: ...funded by National Institutes of Health of the United States of America grants R01HD078641 (D.F.C. and K.I.A) and... https://t.co/9TiHBoCnZY https://t.co/XepycOk6WM

Apr 1, 2023 · 4,145 followers View post →
jrt1201a
@jrt1201a · X

DDX3Y is likely the key spermatogenic factor in the AZFa region that contributes to human non-obstructive azoospermia https://t.co/9DrETi3J9a

Jun 16, 2023 · 75 followers View post →
Ftiliti
@Ftiliti · X

DDX3Y is likely the key spermatogenic factor in the AZFa region that ... - https://t.co/reOJMrQHS4 https://t.co/gihzsTj24g

Mar 31, 2023 · 73 followers View post →
ychrompapers
@ychrom_papers · X

DDX3Y is likely the key spermatogenic factor in the AZFa region that contributes to human non-obstructive azoospermia https://t.co/m2HH73IWDg https://t.co/RSxjHNZxl9

Apr 3, 2023 · 32 followers View post →

All mentions

jrt1201a
@jrt1201a · X

DDX3Y is likely the key spermatogenic factor in the AZFa region that contributes to human non-obstructive azoospermia https://t.co/9DrETi3J9a

Jun 16, 2023 · 75 followers View post →
ychrompapers
@ychrom_papers · X

DDX3Y is likely the key spermatogenic factor in the AZFa region that contributes to human non-obstructive azoospermia https://t.co/m2HH73IWDg https://t.co/RSxjHNZxl9

Apr 3, 2023 · 32 followers View post →
Stigmabase | ORG
@StigmabaseO · X

TW : DDX3Y is likely the key spermatogenic factor in the AZFa region that contributes to human...: ...funded by National Institutes of Health of the United States of America grants R01HD078641 (D.F.C. and K.I.A) and... https://t.co/9TiHBoCnZY https://t.co/XepycOk6WM

Apr 1, 2023 · 4,145 followers View post →
Ftiliti
@Ftiliti · X

DDX3Y is likely the key spermatogenic factor in the AZFa region that ... - https://t.co/reOJMrQHS4 https://t.co/gihzsTj24g

Mar 31, 2023 · 73 followers View post →