Transl Psychiatry March 2023 PMID 37002202

Kynurenine aminotransferase II inhibition promotes sleep and rescues impairments induced by neurodevelopmental insult.

Snezana Milosavljevic, Andrew K Smith, Courtney J Wright, Homayoun Valafar, Ana Pocivavsek

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Mentions

Peak: 5 in Sep 2022

across 3 sources since Sep 2022

Extended reach

216,103

potential audience

Total likes

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Mentions per month

Sep 2022 – Aug 2023

Where it's discussed

X / Twitter8 posts
Facebook2 posts
YouTube1 videos

AI synopsis

What people are saying

The overall tone showcases strong agreement and recognition of the study’s significance, exemplified by phrases like 'promotes sleep and rescues impairments,' indicating support for the findings. Words like 'therapeutic' and hashtags such as '#bioRxiv' suggest recognition of the potential impact on future neurodevelopmental treatments, although engagement remains somewhat surface-level with limited critical analysis.

AgreementStrong agreement

Most discussions strongly agree with the publication's findings, highlighting its significance for sleep research and neurodevelopmental studies.

InterestModerate interest

There is moderate interest, with users emphasizing the therapeutic potential and neurobiological implications, but some posts lack detailed curiosity or exploration.

EngagementModerate engagement

Posts demonstrate some level of engagement by referencing implications and basic results, but few delve into detailed mechanisms or critiques.

ImpactHigh impact

The discussions reflect a high potential impact by suggesting new therapeutic avenues and emphasizing the importance of targeting KYNA pathways in neuropsychological disorders.

Abstract in brief

Elevated levels of kynurenic acid (KYNA) in the brain, associated with neuropsychiatric disorders like schizophrenia and bipolar disorder, may contribute to sleep problems by inhibiting key neurotransmitter systems.
The study used a rat model where KYNA levels were increased during fetal development, then tested a drug (PF04859989) that inhibits KAT II to lower KYNA in adulthood, which improved sleep quality and architecture.
Administering the KAT II inhibitor helped restore normal sleep patterns, particularly when given at specific times, and showed benefits such as increased NREM sleep quality, suggesting that targeting KYNA production could be a therapeutic strategy for sleep impairments linked to neurodevelopmental issues.

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All mentions

Inhibition of Kynurenine Aminotransferase II Enhances Sleep Quality and Rescues Impairments

Social RTCL TV · Aug 3, 2023 32 views

DTHSTR

@CDADeathStar · X

Kynurenine aminotransferase II inhibition promotes sleep and rescues impairments induced null https://t.co/yUfQmpZOKB #DTHSTR

Apr 1, 2023 · 113 followers View post →

Sleep Research

@SleepResearch_ · X

Kynurenine aminotransferase II inhibition promotes sleep and rescues impairments induced by neurodevelopmental insult https://t.co/romO9DdeV6

Apr 1, 2023 · 7,257 followers View post →

Sleep Research

@SleepResearch_ · X

Kynurenine aminotransferase II inhibition promotes sleep and rescues impairments induced by neurodevelopmental insult https://t.co/7sgv2Q7I8X

Apr 1, 2023 · 3 likes · 7,257 followers View post →

Biorxiv Reddit

@BiorxivReddit · X

Kynurenine aminotransferase II inhibition promotes sleep and rescues impairments induced by neurodevelopmental insult https://t.co/yGbY4jWOf2

Sep 22, 2022 · 1 like · 39 followers View post →

Rene Sugar

@renesugar · X

Kynurenine aminotransferase II inhibition promotes sleep and rescues impairments induced by neurodevelopmental insult https://t.co/Y25cJ6rBN5

Sep 22, 2022 · 1 like · 3,970 followers View post →

Unreadable Preprint Bot

@UnReadBot · X

Kynurenine aminotransferase II inhibition promotes sleep and rescues impairments induced by neurodevelopmental insult FK grade 18

Sep 22, 2022 · 16 followers View post →

bioRxiv Neuroscience

@biorxiv_neursci · X

Kynurenine aminotransferase II inhibition promotes sleep and rescues impairments induced by neurodevelopmental insult https://t.co/grKqQ2IrtG #biorxiv_neursci

Sep 22, 2022 · 60,056 followers View post →

bioRxiv

@biorxivpreprint · X

Kynurenine aminotransferase II inhibition promotes sleep and rescues impairments induced by neurodevelopmental insult https://t.co/Yjt19H5bOw #bioRxiv

Sep 22, 2022 · 2 likes · 137,364 followers View post →