Nat Commun April 2023 PMID 37005422

Sialidases and fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria.

Bashar Shuoker, Michael J Pichler, Chunsheng Jin, Hiroka Sakanaka, Haiyang Wu, Ana Martínez Gascueña, Jining Liu, Tine Sofie Nielsen, Jan Holgersson, Eva Nordberg Karlsson, Nathalie Juge, Sebastian Meier, Jens Preben Morth, Niclas G Karlsson, Maher Abou Hachem

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Mentions

16
Peak: 5 in Sep 2022
across 4 sources since Sep 2022

Extended reach

149,886
potential audience

Total likes

10

Video views

63

Mentions per month

Sep 2022 – Jul 2023

Where it's discussed

  • X / Twitter10 posts
  • Facebook3 posts
  • Blogs2 articles
  • YouTube1 videos

AI synopsis

What people are saying

This collection of discussions reveals a high level of enthusiasm and curiosity about the enzyme functions in A. muciniphila, as seen in expressions like 'unprecedented insight' and mentions of nutrient sharing mechanisms. The tone is technical yet enthusiastic, emphasizing the importance of understanding mucin-degrading enzymes and their potential impact on gut health.

AgreementStrong agreement

Most discussions acknowledge the significance of the research in elucidating enzyme functions and their role in microbial interactions, showing strong support.

InterestHigh interest

The posts demonstrate high engagement with phrases like 'unprecedented mechanistic insight' and highlight the relevance of mucin degradation, indicating high interest.

EngagementHigh engagement

Many discussions reference specific enzymes and their effects on gut bacteria, suggesting deep engagement and scientific curiosity.

ImpactHigh impact

The emphasis on nutrient sharing, enzyme roles, and implications for gut health reflect perceived high impact within microbiome research and health sciences.

Abstract in brief

  • Akkermansia muciniphila is important for breaking down mucin in the gut and sharing nutrients with other mucus-associated bacteria.
  • The study identifies specific enzymes called sialidases and fucosidases that remove protective sugar caps from mucin, revealing novel enzyme structures and their role in mucin degradation.
  • Removing these sugar caps doesn't directly help A. muciniphila grow, but it encourages the production of butyrate by neighboring bacteria, which is beneficial for gut health.]

Top posts

Most liked on X and Bluesky
Yuta Sugiyama
@GNTocr3 · X

Sialidases and Fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria https://t.co/oAanEJMUpU

Sep 14, 2022 · 7 likes · 1 share · 128 followers View post →
bioRxiv
@biorxivpreprint · X

Sialidases and Fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria https://t.co/yBHifQPqG5 #bioRxiv

Sep 11, 2022 · 1 like · 1 share · 136,933 followers View post →
Rene Sugar
@renesugar · X

https://t.co/wBlWG5rOnt "This study brings unprecedented mechanistic insight into the initiation of mucin O-glycan degradation by A. muciniphila and nutrient sharing between mucus-associated bacteria."

Apr 4, 2023 · 3,951 followers View post →
Rene Sugar
@renesugar · X

Sialidases and fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria https://t.co/wBlWG5rOnt

Apr 4, 2023 · 3,951 followers View post →
Rene Sugar
@renesugar · X

https://t.co/wBlWG5rOnt "Remarkably, neither the sialic acid nor fucose contributed to A. muciniphila growth, but instead promoted butyrate production by co-cultured Clostridia."

Apr 4, 2023 · 3,951 followers View post →
Takatsugu Miyazaki
@taka_enzyme · X

RT @GNTocr3: Sialidases and Fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associat…

Sep 15, 2022 · 1 share · 378 followers View post →

All mentions

Rene Sugar
@renesugar · X

https://t.co/wBlWG5rOnt "This study brings unprecedented mechanistic insight into the initiation of mucin O-glycan degradation by A. muciniphila and nutrient sharing between mucus-associated bacteria."

Apr 4, 2023 · 3,951 followers View post →
Rene Sugar
@renesugar · X

https://t.co/wBlWG5rOnt "Remarkably, neither the sialic acid nor fucose contributed to A. muciniphila growth, but instead promoted butyrate production by co-cultured Clostridia."

Apr 4, 2023 · 3,951 followers View post →
Rene Sugar
@renesugar · X

Sialidases and fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria https://t.co/wBlWG5rOnt

Apr 4, 2023 · 3,951 followers View post →
micropapers
@micro_papers · X

Sialidases and fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria https://t.co/8Ut2Uz50JF

Apr 3, 2023 · 332 followers View post →
Empyrean Protocol
@empyreanprotoc1 · X

Sialidases and fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria:https://t.co/SqmeEDVf60 #dark_web

Apr 2, 2023 · 58 followers View post →
Takatsugu Miyazaki
@taka_enzyme · X

RT @GNTocr3: Sialidases and Fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associat…

Sep 15, 2022 · 1 share · 378 followers View post →
Yuta Sugiyama
@GNTocr3 · X

Sialidases and Fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria https://t.co/oAanEJMUpU

Sep 14, 2022 · 7 likes · 1 share · 128 followers View post →
Hector Oreliana
@Hector_OFF · X

RT @biorxivpreprint: Sialidases and Fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-…

Sep 11, 2022 · 1 share · 94 followers View post →
Biorxiv Reddit
@BiorxivReddit · X

Sialidases and Fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria https://t.co/Ri0kwgcnmN

Sep 11, 2022 · 39 followers View post →
bioRxiv
@biorxivpreprint · X

Sialidases and Fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria https://t.co/yBHifQPqG5 #bioRxiv

Sep 11, 2022 · 1 like · 1 share · 136,933 followers View post →