HELLO DARKNESS MY OLD FRIEND
Downregulation of cardiac PIASy inhibits Cx43 SUMOylation and ameliorates ventricular arrhythmias in a rat model of myocardial ischemia/reperfusion injury.
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Apr 2023 – Nov 2025Where it's discussed
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Bluesky98 posts
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X / Twitter4 posts
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YouTube1 videos
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What people are saying
Most social discussions are superficial or tangential, with examples like casual comments about personal preferences, ongoing projects, or unrelated news, which demonstrate a lack of deep engagement with the scientific publication. The tone varies from dismissive to mildly curious, reflecting low participation in meaningful analysis or debate.
Generally, the collection shows neutral to slightly positive reactions, with some users expressing curiosity or acknowledgment of the study's significance, but no strong agreement or disagreement about its outcomes.
Most discussions seem disconnected or superficial, with little focused interest in the scientific content, typically mentioning unrelated topics or casual remarks.
Engagement is low; many messages are brief, dismissive, or merely referencing general topics without delving into the paper's methodology or implications.
The overall discussion appears to have negligible impact, as few comments are substantive or indicate influence on opinions or practices; it largely remains surface-level chatter.
Abstract in brief
- PIASy is an enzyme that modifies the protein Cx43 through a process called SUMOylation, which affects heart cell connections.
- Reducing PIASy levels in rats lessened the damage and irregular heartbeats caused by blood flow blockage and restoration (ischemia-reperfusion injury).
- Lowering PIASy decreased Cx43 SUMOylation, increased Cx43 phosphorylation and PKP2 levels, and ultimately improved heart rhythm during injury.]
Top posts
Most liked on X and BlueskyI have this tattooed on my arm. “And I love you. You’re the start of my soul and you’re the end.” -Mahmoud Darwish excerpt from the poem The Pigeons
Downregulation of cardiac PIASy inhibits Cx43 SUMOylation and ameliorates ventricular arrhythmias in a rat model of myocardial ischemia/reperfusion injury https://t.co/8lko0Iqsha
Downregulation of cardiac PIASy inhibits Cx43 SUMOylation... : Chinese Medical Journal Downregulation of cardiac PIASy inhibits Cx43 SUMOylation and ameliorates ventricular arrhythmias in a rat model of myocardial ischemia/reperfusion injury https://t.co/bYvK1MOehx
Downregulation of cardiac PIASy inhibits Cx43 SUMOylation and ameliorates ventricular arrhythmias in a rat model of myocardial ischemia/reperfusion injury https://t.co/YryelBCxW1
Downregulation of cardiac PIASy inhibits Cx43 SUMOylation and ameliorates ventricular arrhythmias in a rat model of myocardial ischemia/reperfusion injury https://t.co/hUWDSrW1wp https://t.co/EgNJdRJipq
All mentions
Cardiac PIASy Downregulation Reduces Arrhythmias Post-Myocardial Injury
Downregulation of cardiac PIASy inhibits Cx43 SUMOylation, reducing ventricular arrhythmias in a rat model of myocardial ischemia-reperfusion injury, thereby improving heart rhythm and reducing tissue damage.
What do you think my oc tastes like? (Rigel (left) has a pinkish undertone and blue gradient hair, while The Protagonist™ is tanned and brown reddish hair :3) #ocsky
Have some of you here already decline to co-author a paper? Can you explain the context and the reasons? How was it received/appreciate by the other people involved?
Baker rob how can I taste your
Curious? We thought you might be. Come explore what we can do for your school, drop us a line at learn@independentthinking.co.uk!
Uniparty pdf-files
im gonna be busy at work tomorrow, but won’t you leave a question (or maybe even anonymous confession
El Rey conmemora los 50 años de monarquía sin la presencia pública de Juan Carlos I. theobjective.com/espana/2025-...
Hi, our tent couldn’t withstand the storm again, and even 2 dollars helps us take a step toward safety.
you CAN eat a tree!
and shes still ugly
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No Hell No!
on dirait mon mari :)
全然お通夜ではなかったが 「こんなんハズビンホテルかサウスパークでしかみねぇよ!!!!」っていうレミゼパロで爆笑してた
Das blöde an Steinen die vor Erleichterung fallen, ist das Nächtliche analysieren dieser
すき家のジークアクスコラボに行こうと思ってスマホですき家のサイトにアクセスして神奈川県の店舗を見たのだが、市町村の並び順序が謎。
저 블락이 진짜 원래 머스크 이전의 트위터였는데... 하...
明日シティらしいけど実感わかんから弟子とポケカしてくる事に
Le problème à gauche c'est les traîtres @partisocialiste.bsky.social aucune alliance avec la clique @olivierfaure.bsky.social !! Aucune voix insoumis ira à eux quoiqu'il arrive me concernant !!
もうなんでもアリよww
Texas will have its day
@ernestoekaizer.bsky.social nos explica, con mucho tino, la mamarrachada de sentencia. Marchena logra una condena "simbólica", sin penas duras, para provocar la dimisión del fiscal general del Estado open.substack.com/pub/ernestoe...
I feel like January 6 was a testing ground. He wants to see how far he can push.
Writing Tip: When you focus too much on why your work is terrible, it can create a spiral where you no longer even want to look at your work. Remind yourself that there is value there. Value worth sharing. It might not be perfect, but it doesn't have to be to be good. #writing #writingtips #Booksky
次でかいセール来たら掃除機買い換えようかな
와 거지다 거지 저는 거지인데 돌리고 알거지되려고요!!
How different do you think pop culture would actually be? I grant a butterfly effect that shuffles the details is likely, but it obscures the movie’s premise if the entire canon of 60s music is swapped out for a similar-sounding but largely different set of songs and artists.
I said that 15hrs ago
I like the way you think.
지금까지 트위터 7년하면서 문제 생긴적이 있었기 때문에 미리 막는 거임
Cześć Jacek dziękuję bardzo
Mis cálculos diarios – Día 21 de noviembre - Número 211125 211125 es el total de cuatro sumas con sumandos anagramáticos entre sí: 211125=102093+109032 211125=102813+108312 211125=103587+107538 211125=105387+105738
I'm mostly just working on timings and getting a very simple loop going. From there I'll take another pass at the environment, then see if I can add more bespoke animations on top of the loop to spice it up.
Buenos días, Esther
Aussies slow going but should be aiming to keep England in the field for 100 overs if they can. It’s a five test series. #ashes
Hello dear, Every night my family lies on the cold ground
It’s gotta be one of the greatest catch 22 situations of all time.
Thank you for your steadfast support for Palestinian dignity and sovereignty. We need everyone in this fight. In solidarity, Team Ilhan Omar
I was gonna send a funny tweet about "Cygames should add Bubba to Umamusume" but Maybe let's try not to turn the pedophile's horse into any kind of pseudo glorified meme
그니까 인간들아 제발 마스크 써 지하철에서 노마스크로 기침할 거면 주둥이 쳐 가려 제발!!! 입이라고 불러주기도 싫어 내 얼굴에 대고 기침한 새끼 지난 2주간 최소 세 마리였다고
HELLO DARKNESS MY OLD FRIEND
えっと、はい……。ファンに、感謝祭の準備をしてる映像をプレゼントする事になったんです……
Thank you!
Especially on rainy nights like this, they would congregate under the bridge, all the boys from nowhere, the boys who lived nowhere, who had nowhere else to go.
Coming from man that tried to over throw election
Meiの旅/ あたしは、今、「Farnsfield」にいるの。目の前に次の施設が見えるわ。 1. ロビン・フッズ・ホイールゲート・パーク この公園は家族連れに人気があるアミューズメントセンターよ。様々なアトラクションがあって、一日中楽しめる場所なの。あたしは、子供と一緒に観覧車やゴーカートで遊ぶのが楽しみだわ。 2. Kindred White Post Nursery and Pre-School ここは、幼稚園と保育園が... (Powered Google map apis,llmjp3-13b-i-ggufq4,Nano-Banana,etc.)
“Asterix and Kafka” sounds intriguing.
With hybrid PC/consoles coming, do you see Sony not allow PC and go back to full exclusivity for timed exclusives? www.resetera.com/threads/13...
Asking Grok a question actually makes me feel inexplicably dirty. Its like getting a little bit too close to the sewer that is Musk's childish, unfunny little mind.
'Workers must demand a special conference of the TUC to instruct their leaders to call a general strike to bring down the Starmer government and bring in a workers government.'
IMPEACH POTUS!!! IMPEACH SCOTUS!!!
THIS is so important. THIS is why the goal of Net Zero matters - as a performance indicator it allows governments, businesses, individuals to see that progress is being made. It also produces competition!
これAI使っても馬鹿になるんじゃなくて既存の積み重ねが逝くだけだな。むしろ総合力は高くなるし全然忙しくもある
Tesla patented their innovative system of using industrial glue to weld togheter the frame of a car. This is the quintessential one-use-only idea applied to cars. While older (petrol) cars were made of rivets and joints and could be fixed these new models are "if it breaks you dump the whole thing".
WHY THE FUCK IS SO MUCH AI IMAGES HERE???????
Oh I just made the same point!
« you hear the twang, and you assume the song is racist but it's just what country music is like »
Been scream-crying into my pillow for over an hour now due to this abdominal pain
hi hello!
Oh you’ll use any excuse!
thing is, ive never been to a Round1... yet. ive been to Dave & Busters before but im hoping Round1 has Guitar Hero Arcade there
"confirmed"? The only country questioning Ukraine sovereignty is Russia. By the way, Crimea and Donetsk are Ukraine too.
I always thought DK and Pauline were dating, and Pauline cheated on him with Mario. So DK kidnapped Pauline, and Mario went looking for her and realized he had to save her, so DK was throwing barrels because he was mad at Mario for stealing his girlfriend.
Never.
www.tiktok.com/t/ZP8U84hNg/ @thebulwark.com @sykescharlie.bsky.social @jvl.bsky.social @thiswillhold.bsky.social @manasco.bsky.social @spoonamore.bsky.social @raylutz.bsky.social @hackingbutlegal.bsky.social @hartmannreport.com @gregpalast.bsky.social @denverr.bsky.social @aoc.bsky.social
I have this tattooed on my arm. “And I love you. You’re the start of my soul and you’re the end.” -Mahmoud Darwish excerpt from the poem The Pigeons
Frick off.
Venerdì
Heel interessant. Het kan altijd dienen tegen drones van waar ze ook mogen komen.
YEAH! Let's go, Billikens.
Rubber nipple boobie bonkers.
$660M
Raheem Sterling was the key player in England's Euro 20 run. He was messed around & forgotten about quickly after. Everything I've seen from Bellingham puts him in the Zidane category; make room for him because he'll win you a game. But the room does seem to feel a bit smaller when they aren't white
A Microsoft update killed 160 printers across our estate.
いいよー
感想が来ないからより自分が求められる方へジャンル移動するって人、根本的に二次創作に対するモチベが違いすぎないか…
お疲れ様です。 もう少しで私も完全体(?)になれますので頑張ります!!
It’s really a feeling that’s hard to recapture. Though Midnight might do it for all Blood Elf characters. Walking in to your first major city and seeing everyone from level 15s to 60s running around behind the gates of Org was amazing back in vanilla
그걸 인지하고 행하는 것도 완전 용기가 필요한 일이고 강단과 의지가 잇어야 하는 일인데 대화하셧다는 점에서 완죠니. 최고의 어른이라고 생각합니다 너무너무 멋진 대감님이야 짱짱 ~
Después de disfrutar ayer este hilo me puse a escuchar a The Rutles haciendo, al ppio, el ejercicio de adivinar la canción a la que copian/homenajean y lo que me sorprendió es que algunas son temazos más de allá de ser 'copias' como 'Eine Kleine Middle Music'. Maravilla descubrirlos con este hilo.
Wozu?
did bluesky change the colour blue on their app icon or has every colour just gotten 10x brighter to me recently (said scared)
Until he fails a bullshit purity test and it's decided that MAGA should win. It's only been happening for a decade. And then the Stay Homes were a generation before that.
www.rfi.fr/fr/afrique/2...
this clip sums up the experience perfectly:
スピーカーがリコールで回収されていったため、当分の間ファイナル無音ファンタジー14です
Downregulation of cardiac PIASy inhibits Cx43 SUMOylation... : Chinese Medical Journal Downregulation of cardiac PIASy inhibits Cx43 SUMOylation and ameliorates ventricular arrhythmias in a rat model of myocardial ischemia/reperfusion injury https://t.co/bYvK1MOehx
Downregulation of cardiac PIASy inhibits Cx43 SUMOylation and ameliorates ventricular arrhythmias in a rat model of myocardial ischemia/reperfusion injury https://t.co/hUWDSrW1wp https://t.co/EgNJdRJipq
Downregulation of cardiac PIASy inhibits Cx43 SUMOylation and ameliorates ventricular arrhythmias in a rat model of myocardial ischemia/reperfusion injury https://t.co/YryelBCxW1
Downregulation of cardiac PIASy inhibits Cx43 SUMOylation and ameliorates ventricular arrhythmias in a rat model of myocardial ischemia/reperfusion injury https://t.co/8lko0Iqsha
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