Protective effect and mechanism insight of purified Antarctic kill phospholipids against mice ulcerative colitis combined with bioinformatics.

Abstract in brief

• The study investigated how Antarctic krill phospholipids (APL) might help treat ulcerative colitis (UC) by using bioinformatics to analyze gene functions and pathways involved in inflammation and cell signaling, and then confirmed the therapeutic effects through animal experiments.
• Bioinformatics analysis showed that genes affected by APL were involved in important processes like cell adhesion, signaling, and immune response, especially via the TNF signaling pathway and tight junction regulation, which are crucial in UC.
• Experiments with mice demonstrated that APL treatment improved UC symptoms, repaired intestinal barrier proteins (ZO1 and occludin), reduced inflammatory cytokines (IL6 and TNF), and positively altered gut microbiota and short-chain fatty acids, suggesting APL could be a beneficial dietary therapy for UC.]