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PLoS Pathog April 2023 PMID 37018380

Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range.

Dongchun Ni, Priscilla Turelli, Bertrand Beckert, Sergey Nazarov, Emiko Uchikawa, Alexander Myasnikov, Florence Pojer, Didier Trono, Henning Stahlberg, Kelvin Lau

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Mentions

3
Peak: 1 in Feb 2023
across 2 sources since Feb 2023

Extended reach

4,059
potential audience

Total likes

5

Video views

20

Mentions per month

Feb 2023 – Aug 2023

Where it's discussed

  • X / Twitter2 posts
  • YouTube1 videos

AI synopsis

What people are saying

Many discussions focus on how the structural insights into ACE2 binding relate to the virus's ability to infect new hosts, using phrases like 'mutations enabling immune escape' and 'expand host range,' which convey the significance and potential implications of the findings. The tone balances technical detail with recognition of the study’s importance, reflecting moderate but meaningful engagement.

AgreementModerate agreement

Most discussions recognize the importance of the research findings, showing general agreement with its conclusions about host range and mutations.

InterestModerate interest

The participants show moderate interest, highlighting the relevance for understanding virus evolution and implications for public health.

EngagementModerate engagement

Comments include references to the methodology and potential consequences, indicating a reasonable level of engagement.

ImpactModerate impact

The discussions acknowledge that the research could influence future studies or strategies related to virus tracking and control, but do not suggest immediate drastic changes.

Abstract in brief

  • The study investigated how different SARS-CoV-2 variants of concern (VOCs), including Beta and various Omicron subvariants, interact with the mouse ACE2 receptor using cryo-electron microscopy, revealing that certain mutations in the Spike protein allow the virus to bind to mouse cells.
  • The structural analysis shows that a combination of specific Spike mutations is necessary for the virus to effectively attach to mouse ACE2, which could mean the virus might infect a broader range of hosts.
  • Understanding these interactions helps assess the potential risk of the virus jumping to new animal species, which could impact future spillover or spillback events between humans and animals.]
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Top posts

Most liked on X and Bluesky
Akio Adachi
@RQpdPyjf1VbJKTe · X

#PLOSPathogens: Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indi ... https://t.co/knkJen9XGb

Apr 5, 2023 · 4 likes · 2,664 followers View post →
Outbreak Science
@outbreaksci · X

New preprint: Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range https://t.co/rS6OVpX1Bs #coronavirus #COVID19

Feb 3, 2023 · 1,376 followers View post →

All mentions

Akio Adachi
@RQpdPyjf1VbJKTe · X

#PLOSPathogens: Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indi ... https://t.co/knkJen9XGb

Apr 5, 2023 · 4 likes · 2,664 followers View post →
Outbreak Science
@outbreaksci · X

New preprint: Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range https://t.co/rS6OVpX1Bs #coronavirus #COVID19

Feb 3, 2023 · 1,376 followers View post →