Genome Med April 2023 PMID 37020259

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19.

Daniela Matuozzo, Estelle Talouarn, Astrid Marchal, Peng Zhang, Jeremy Manry, Yoann Seeleuthner, Yu Zhang, Alexandre Bolze, Matthieu Chaldebas, Baptiste Milisavljevic, Adrian Gervais, Paul Bastard, Takaki Asano, Lucy Bizien, Federica Barzaghi

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Mentions

105

Peak: 78 in Apr 2023

across 3 sources since Oct 2022

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560,028

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Oct 2022 – Feb 2025

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AI synopsis

What people are saying

Several posts highlight specific aspects of the study, such as the role of TLR3 and TLR7 variants and their link to severe COVID-19, with phrases like 'at-risk variants' and 'genetic basis for why some people get super sick' illustrating a deep understanding of the subject matter. The tone is often enthusiastic and curious, with words like 'thrilled' and 'finally' conveying excitement about advancements in medical research related to COVID-19.

AgreementModerate agreement

Most posts express agreement with the study's findings regarding genetic factors in severe COVID-19 cases.

InterestHigh interest

A significant number of posts show high interest, as participants frequently reference the publication and its implications.

EngagementHigh engagement

Many discussions delve into specific genetic mechanisms and potential outcomes, indicating a high level of engagement with the material.

ImpactHigh impact

Users overwhelmingly perceive the findings as highly impactful in understanding COVID-19 susceptibility and severity.

Abstract in brief

The study identifies that 15-20% of severe COVID-19 cases in unvaccinated patients are linked to impaired type I interferon (IFN) activity due to genetic factors or autoantibodies.
A genome-wide analysis of 3269 unvaccinated severe COVID-19 patients revealed significant associations with rare variants in the TLR7 gene, which may increase susceptibility to life-threatening COVID-19.
Findings suggest that rare genetic variants related to TLR3 and TLR7 play a major role in severe COVID-19 risk, especially in younger patients under 60 years of age, indicating potential areas for further research and understanding of COVID-19 severity.

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Genetic Variants in Type I IFN Genes Linked to Severe COVID-19

This study reveals that 15-20% of severe COVID-19 cases in unvaccinated patients are associated with impaired type I interferon (IFN) activity due to genetic factors. It highlights significant links to rare variants in…

Medicine RTCL TV · Jul 17, 2023 56 views

Gerda Kappert

@KappertGerda · X

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 | Genome Medicine | Full Text https://t.co/wSCp5VVokg

Feb 4, 2025 · 417 followers View post →

Dr L Boominathan PhD

@DrLBoominathan · X

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 https://t.co/DPKotWPFKK How does a p53 activator protect against COVID-19? TP53 activator->

Sep 26, 2024 · 876 followers View post →

Nick #RespiratorsFilterPathogens

@NickAnderegg · X

@x3r0gxx For example, this study found a rare combination of genes can lead to a specific immune deficiency that leads to more severe covid: https://t.co/urMK58ciGJ

Mar 23, 2024 · 1 like · 7,156 followers View post →

the paper link

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Trend up+23: Matuozzo D, ..., Cobat A (Genome Med) __Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19__ https://t.co/W5DdBmYV4G

Jan 16, 2024 · 136 followers View post →

Stigmabase | NORTH

@StigmabaseN · X

TW : Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated...: ...Brussels, Belgium. 93 Nuffield Department of Medicine, Ludwig Institute for Cancer Research, Oxford University, Oxford, UK. 94 Department of… https://t.co/kVkUl1jfBF

Jan 8, 2024 · 1,745 followers View post →

Biblioteca HUCA

@BibliotecaHUCA · X

PubMed-https://t.co/sC3GMyWvLn Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 @HUCA_Asturias #publiHUCA @ASIV_Asturias #Immunology @ralonsoarias #Covid_19 https://t.co/41rE7k4de2

Jan 8, 2024 · 2 likes · 1,700 followers View post →

the paper link

@the_paper_link · X

Trend up+188: Matuozzo D, ..., Cobat A (Genome Med) __Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19__ https://t.co/W5DdBmYV4G

Jan 8, 2024 · 136 followers View post →

I am a science bot

@hot_sci_summer · X

Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 https://t.co/MlXinDQ9aP

Jan 7, 2024 · 8 followers View post →

NDMPapers

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Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 https://t.co/VPnQ7TR0ET

Jan 7, 2024 · 344 followers View post →

Center for Military Precision Health (CMPH)

@theCMPH · X

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 ... https://t.co/LWaALH0Z3W

Aug 31, 2023 · 7 followers View post →

Vince Beltran, Ph.D.

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RT @casanova_lab: 1/ We are thrilled to share our latest paper published in @GenomeMedicine

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Genome Medicine

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UGent Bibliography

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PubMed Trending

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Trending on PubMed: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19. https://t.co/ngFjTwQ8Y8

Apr 20, 2023 · 1 like · 5,155 followers View post →

BMC

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RT @casanova_lab: 1/ We are thrilled to share our latest paper published in @GenomeMedicine

Apr 18, 2023 · 37 shares · 82 followers View post →

Ashish Marwaha BMBCh, MA, PhD, FABMGG,FCCMG, FRCPC

@DrAshM2 · X

RT @naomiattar: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 https:/…

Apr 16, 2023 · 2 shares · 1,480 followers View post →

CFlores-Lab

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Florence Tubach

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Naomi Attar

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Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 https://t.co/HtqksSK5dn

Apr 14, 2023 · 9 likes · 2 shares · 1,241 followers View post →

Maria da Glória

@glosousa1 · X

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Irish Immunology

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Philippa says pay NHS workers fairly

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Yoni - יוני (and Rebecca too)

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Ivan Zanoni

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Don Vinh

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imran tipu

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Dervis Salih

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Julian Rojas

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Casanova Lab

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1/ We are thrilled to share our latest paper published in @GenomeMedicine

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CFlores-Lab

@LabCflores · X

RT @GenomeMedicine: New #COVID19 research from @AurelieCobat @casanova_lab & co. @RockefellerUniv highlighting how rare variants of TLR3- a…

Apr 12, 2023 · 9 shares · 608 followers View post →

Stuart Tangye

@stutangye · X

RT @GenomeMedicine: New #COVID19 research from @AurelieCobat @casanova_lab & co. @RockefellerUniv highlighting how rare variants of TLR3- a…

Apr 12, 2023 · 9 shares · 2,081 followers View post →

Rockefeller University

@RockefellerUniv · X

RT @GenomeMedicine: New #COVID19 research from @AurelieCobat @casanova_lab & co. @RockefellerUniv highlighting how rare variants of TLR3- a…

Apr 12, 2023 · 9 shares · 20,522 followers View post →

Maresurfer {...}

@maresurfer · X

RT @GenomeMedicine: New #COVID19 research from @AurelieCobat @casanova_lab & co. @RockefellerUniv highlighting how rare variants of TLR3- a…

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Casanova Lab

@casanova_lab · X

RT @GenomeMedicine: New #COVID19 research from @AurelieCobat @casanova_lab & co. @RockefellerUniv highlighting how rare variants of TLR3- a…

Apr 12, 2023 · 9 shares · 10,040 followers View post →

Genome Medicine

@GenomeMedicine · X

Apr 12, 2023 · 21 likes · 9 shares · 24,734 followers View post →

MedicalTwit

@MedicalTwitAcct · X

RT @exosome: Finally we are getting closer to establishing a genetic basis for why some people get super sick from covid19 and others dont…

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fon

@alfondotnet · X

RT @exosome: Finally we are getting closer to establishing a genetic basis for why some people get super sick from covid19 and others dont…

Apr 10, 2023 · 29 shares · 791 followers View post →

Biblioteca HUCA

@BibliotecaHUCA · X

PubMed- https://t.co/nWsx8asfTH Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 @HUCA_Asturias #publiHUCA #Immunology #Covid_19

Apr 10, 2023 · 1 like · 1,700 followers View post →

BlueChipFuego

@JackKnifeJockey · X

RT @exosome: Finally we are getting closer to establishing a genetic basis for why some people get super sick from covid19 and others dont…

Apr 9, 2023 · 29 shares · 1,060 followers View post →

Lonnie R Marcum, PT, BSHCA

@LonnieRhea · X

RT @exosome: Finally we are getting closer to establishing a genetic basis for why some people get super sick from covid19 and others dont…

Apr 8, 2023 · 29 shares · 3,808 followers View post →

Europe PMC articles

@EuropePMC · X

New from #ERC_Research https://t.co/NvTDcIx2vp Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19.

Apr 8, 2023 · 1,552 followers View post →

815wrldtrvlr

@815wrldtrvlr · X

RT @exosome: Finally we are getting closer to establishing a genetic basis for why some people get super sick from covid19 and others dont…

Apr 8, 2023 · 29 shares · 36,605 followers View post →

Eve.S.

@yeeseak · X

RT @exosome: Finally we are getting closer to establishing a genetic basis for why some people get super sick from covid19 and others dont…

Apr 8, 2023 · 29 shares · 867 followers View post →

satoshi

@satoshi84570237 · X

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 | Genome Medicine | Full Text (https://t.co/84DXW1TTV0)

Apr 8, 2023 · 50 followers View post →

Ramona G

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RT @exosome: Finally we are getting closer to establishing a genetic basis for why some people get super sick from covid19 and others dont…

Apr 8, 2023 · 29 shares · 654 followers View post →

Ofer Neiman #StopArmingIsrael

@ofer_n · X

RT @exosome: Finally we are getting closer to establishing a genetic basis for why some people get super sick from covid19 and others dont…

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#Justice4Hepzi:Justice4Sharyn:Justice4Leighanne

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RT @exosome: Finally we are getting closer to establishing a genetic basis for why some people get super sick from covid19 and others dont…

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♠️magz©️

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RT @exosome: Finally we are getting closer to establishing a genetic basis for why some people get super sick from covid19 and others dont…

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Bettina Struff #Woke #FBPE #FBPR #NHS #RejoinEU

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RT @exosome: Finally we are getting closer to establishing a genetic basis for why some people get super sick from covid19 and others dont…

Apr 8, 2023 · 29 shares · 4,066 followers View post →

KayLKelley

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RT @exosome: Finally we are getting closer to establishing a genetic basis for why some people get super sick from covid19 and others dont…

Apr 7, 2023 · 29 shares · 705 followers View post →

RA Watt

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RT @exosome: Finally we are getting closer to establishing a genetic basis for why some people get super sick from covid19 and others dont…

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dixonsgtusmc@yahoo.com

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RT @exosome: Finally we are getting closer to establishing a genetic basis for why some people get super sick from covid19 and others dont…

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B Hanson

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RT @exosome: Finally we are getting closer to establishing a genetic basis for why some people get super sick from covid19 and others dont…

Apr 7, 2023 · 29 shares · 2,702 followers View post →

AmericanEgoist

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RT @exosome: Finally we are getting closer to establishing a genetic basis for why some people get super sick from covid19 and others dont…

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RINO Rooter

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Dr Martin

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Marlene Robin

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Apr 7, 2023 · 29 shares · 594 followers View post →

NEMANI Mona PhD, MBA

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https://t.co/0hv3msZQaD

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Smallthrottledaccount

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RT @exosome: Finally we are getting closer to establishing a genetic basis for why some people get super sick from covid19 and others dont…

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lord “Spike Protein”

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RT @exosome: Finally we are getting closer to establishing a genetic basis for why some people get super sick from covid19 and others dont…

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Nick Melia

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Rev. Kate Morgan, GAOTU/M.A.

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Dr. Philip Eckardt, MD

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RT @exosome: Finally we are getting closer to establishing a genetic basis for why some people get super sick from covid19 and others dont…

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ACHS Research

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New NUTRITION Research Available. Click Here to Access Article(s): https://t.co/92loNdmAkp

Apr 7, 2023 · 44 followers View post →

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Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19. https://t.co/6dCE64nby1

Apr 7, 2023 · 21 followers View post →

StandWithArmenia

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RT @mekinian2: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19. https:/…

Apr 6, 2023 · 1 share · 453 followers View post →

Arsene Mekinian

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Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19. https://t.co/UOxHw4ZiDM

Apr 6, 2023 · 1 share · 1,046 followers View post →

Cristel 70

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RT @NovelliGnovelli: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 ht…

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Selene Cipri

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RT @NovelliGnovelli: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 ht…

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Giuseppe novelli

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Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 https://t.co/OXWTaXvd0v

Nov 1, 2022 · 1 like · 2 shares · 3,655 followers View post →

COVID-19_arXiv

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Oct 28, 2022 · 1 share · 4,520 followers View post →

Outbreak Science

@outbreaksci · X

New preprint: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19 https://t.co/BKQILAvDO0 #influenza #COVID19

Oct 28, 2022 · 1,376 followers View post →

SeqComplete

@SeqComplete · X

Top story: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with critical COVID-19 | medRxiv https://t.co/10H4LsUcFT, see more https://t.co/bYYQsXi8Go

Oct 27, 2022 · 4,411 followers View post →

BibliotecaHUVH

@BibliotecaHUVH · X

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with critical COVID-19 https://t.co/0TcgImwkFB [Preprint] @medrxivpreprint

Oct 27, 2022 · 2,314 followers View post →

Prof. Dr. Sanjeev Bagai

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Oct 26, 2022 · 2 likes · 34,750 followers View post →

medRxiv

@medrxivpreprint · X

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with critical COVID-19 https://t.co/V3TM9o6zg1 #medRxiv

Oct 25, 2022 · 17,465 followers View post →

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19.

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Genetic Variants in Type I IFN Genes Linked to Severe COVID-19