Genomic alterations in neuroendocrine prostate cancer: A systematic review and meta-analysis.

Abstract in brief

• This systematic review and meta-analysis examined the genetic changes in neuroendocrine prostate cancer (NEPC), a very aggressive form of prostate cancer, by analyzing data from 14 studies involving 449 patients to identify common gene mutations and copy number alterations (CNAs).
• The most frequently mutated gene in NEPC was 498, and common CNAs included gene losses and amplifications, with certain alterations like concurrent mutations being especially prevalent, especially in de novo NEPC compared to treatment-related cases.
• The study emphasizes the importance of genetic testing for personalized treatment options, highlights key genomic differences between NEPC types, and suggests further research to explore specific NEPC subtypes for better targeted therapies.]