Nat Commun April 2023 PMID 37029109

ASPSCR1::TFE3 orchestrates the angiogenic program of alveolar soft part sarcoma.

Miwa Tanaka, Surachada Chuaychob, Mizuki Homme, Yukari Yamazaki, Ruyin Lyu, Kyoko Yamashita, Keisuke Ae, Seiichi Matsumoto, Kohei Kumegawa, Reo Maruyama, Wei Qu, Yohei Miyagi, Ryuji Yokokawa, Takuro Nakamura

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Peak: 2 in Apr 2023

across 3 sources since Apr 2023

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The discussions reflect a strong interest in the molecular mechanisms presented, with some posters emphasizing the importance of the angiogenic program and its implications for treatment, using words like 'crucial' and 'significant.' The tone exhibits curiosity and recognition of the research's importance, suggesting that readers see this work as impactful in the broader context of cancer biology.

AgreementModerate agreement

Most discussions recognize the significance of the research, with some explicitly stating the crucial role of ASPSCR1::TFE3 in tumor growth and angiogenesis.

InterestHigh interest

Many comments show high curiosity and interest, mentioning potential implications for cancer therapy and scientific understanding.

EngagementModerate engagement

Comments include detailed reflections on the mechanisms described in the publication, indicating moderate to deep engagement.

ImpactModerate impact

Poster reactions suggest the research could influence future studies and clinical approaches, highlighting its potential impact.

Abstract in brief

ASPSCR1TFE3 is a fusion transcription factor linked to alveolar soft part sarcoma (ASPS), a cancer affecting young people characterized by a highly vascular and metastatic nature.
While ASPSCR1TFE3 is not essential for tumor cell survival in lab conditions, it is crucial for tumor growth in living organisms because it promotes angiogenesis, the formation of new blood vessels.
The factor influences enhancer regions in DNA, especially superenhancers, to regulate genes like Pdgfb, Rab27a, Sytl2, and Vwf, which are important for vascular development and support the tumor's blood supply.

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All mentions

Role of ASPSCR1 TFE3 in Alveolar Soft Part Sarcoma Angiogenesis

ASPSCR1 TFE3 is a fusion transcription factor linked to alveolar soft part sarcoma, promoting tumor growth through angiogenesis by regulating genes vital for blood vessel formation.

STEM RTCL TV · Jul 22, 2023 45 views

CRISPRpapers

@CRISPR_papers · X

ASPSCR1::TFE3 orchestrates the angiogenic program of alveolar soft part sarcoma https://t.co/vB4nxYYZNE

Apr 11, 2023 · 3,894 followers View post →

BeEr

@BEeR_chuaychob · X

Apr 7, 2023 · 2 likes · 55 followers View post →