Signal Transduct Target Ther April 2023 PMID 37045827

Patient-derived xenograft models in cancer therapy: technologies and applications.

Yihan Liu, Wantao Wu, Changjing Cai, Hao Zhang, Hong Shen, Ying Han

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Peak: 1 in Apr 2023

across 4 sources since Apr 2023

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Apr 2023 – Aug 2023

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AI synopsis

What people are saying

Discussions highlight the importance of PDX models in capturing patient-specific tumor characteristics, with posts mentioning 'more accurate representation' and 'advancements in engraftment techniques.' The tone ranges from informative to cautiously optimistic, emphasizing the transformative potential of integrating new technologies for cancer research.

AgreementModerate agreement

Most discussions acknowledge the value of PDX models in improving cancer research and therapy, indicating general agreement with the article’s conclusions.

InterestModerate interest

The posts show moderate interest, with some expressing curiosity about technological advancements like multi-omics and deep learning in PDX applications.

EngagementModerate engagement

Conversations include specific references to the techniques and potential benefits, showing a moderate depth of engagement.

ImpactModerate impact

Participants recognize the significance of PDX models for personalized medicine and drug testing, suggesting the article’s moderate influence on current research discourse.

Abstract in brief

Patient-derived xenograft (PDX) models are created by implanting human tumor tissues into mice, providing a more accurate representation of cancer characteristics and preservation of patient-specific genomic features.
The advancement of PDX engraftment techniques and integration of technologies like multi-omics and deep learning allow for a detailed understanding of the molecular landscape of tumors, enhancing their application in cancer research.
This review outlines the history and establishment of PDX models, analyzes their pros and cons, and discusses their various applications in drug testing and cancer treatment strategies, including chemotherapy and immunotherapy.

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