Nat Commun April 2023 PMID 37045843

The RNA-binding protein landscapes differ between mammalian organs and cultured cells.

Joel I Perez-Perri, Dunja Ferring-Appel, Ina Huppertz, Thomas Schwarzl, Sudeep Sahadevan, Frank Stein, Mandy Rettel, Bruno Galy, Matthias W Hentze

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Peak: 6 in Feb 2022

across 2 sources since Feb 2022

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Feb 2022 – Jul 2023

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The collective discussions underscore the importance of the study by referencing its use of innovative methods like eRIC and highlighting findings such as organ-specific RNA-binding profiles; the tone emphasizes the groundbreaking nature of the research and its implications for understanding metabolism and gene regulation.

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All discussions strongly support the significance of the findings, highlighting the novelty and relevance of the research.

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The discussions demonstrate high curiosity, emphasizing the technological advances and biological implications of the study.

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Posts delve into methodological details, mentioning resources like eRIC and specific organ differences, indicating deep engagement.

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Participants recognize the potential influence on future research, especially in understanding organ-specific gene regulation and RNA-protein interactions.

Abstract in brief

The study introduces a method called ex vivo enhanced RNA interactome capture (eRIC) to identify RNA-binding proteins in mammalian organs like brain, kidney, and liver, revealing over 1300 RBPs, including many not found in cultured cells, such as metabolic enzymes.
RBP activity varies between different organs and is not just dependent on protein abundance, indicating organ-specific regulatory mechanisms; notably, enzymes involved in metabolism show significant RNA-binding activity.
The findings highlight a close relationship between gene expression and metabolism, especially through enzymes that use nucleotide cofactors, and demonstrate that organ tissues have distinct RNA-binding profiles compared to cultured cells, providing a valuable resource for future research.]

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Divergence in RNA-binding Proteins Between Mammalian Organs and Cultured Cells

This study introduces ex vivo enhanced RNA interactome capture (eRIC) to identify RNA-binding proteins in mammalian organs like brain, kidney, and liver, revealing over 1300 RBPs. Organ-specific regulatory mechanisms…

STEM RTCL TV · Jul 18, 2023 95 views

RRID Robot

@RobotRrid · X

.@ChromoTekGmbH your resource, https://t.co/2Ec4rzZhnN, was just reported to be used in "The RNA-binding protein landscapes differ between…": https://t.co/8Sglfn5ADT (https://t.co/biilzsNCe0). Thank you for making your #methodsmatter. #RRID

Apr 19, 2023 · 161 followers View post →

Catarina Cunha

@clemoscatarina · X

The RNA-binding protein landscapes differ between mammalian organs and cultured cells https://t.co/ogoe594yyE

Apr 13, 2023 · 1,767 followers View post →

The Secretome

@TheSecretome · X

The RNA-binding protein landscapes differ between mammalian organs and cultured cells ⁦@biorxivpreprint⁩ ⁦@HentzeTeam⁩ #RBP #metabolism #eRIC https://t.co/tR66KsmEvb

Feb 16, 2022 · 3 likes · 888 followers View post →

備忘録

@bibourokuabc · X

RT @biorxivpreprint: The RNA-binding protein landscapes differ between mammalian organs and cultured cells https://t.co/AbtDqX6DVh #bioRxiv

Feb 11, 2022 · 4 shares · 227 followers View post →

Martin Smith

@Trevor87Smith · X

RT @biorxivpreprint: The RNA-binding protein landscapes differ between mammalian organs and cultured cells https://t.co/AbtDqX6DVh #bioRxiv

Feb 11, 2022 · 4 shares · 276 followers View post →

De-en Sun

@DeenSun3 · X

RT @biorxivpreprint: The RNA-binding protein landscapes differ between mammalian organs and cultured cells https://t.co/AbtDqX6DVh #bioRxiv

Feb 11, 2022 · 4 shares · 419 followers View post →

Krysta Coyle, PhD

@molecularkrysta · X

RT @biorxivpreprint: The RNA-binding protein landscapes differ between mammalian organs and cultured cells https://t.co/AbtDqX6DVh #bioRxiv

Feb 10, 2022 · 4 shares · 2,458 followers View post →

bioRxiv

@biorxivpreprint · X

The RNA-binding protein landscapes differ between mammalian organs and cultured cells https://t.co/AbtDqX6DVh #bioRxiv

Feb 10, 2022 · 27 likes · 4 shares · 136,940 followers View post →

The RNA-binding protein landscapes differ between mammalian organs and cultured cells.

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Divergence in RNA-binding Proteins Between Mammalian Organs and Cultured Cells