Front Nutr March 2023 PMID 37063330

The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the liver, and support the brain.

Timothy S Harlan, Rachel V Gow, Andreas Kornstädt, P Wolfram Alderson, Robert H Lustig

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Mentions

106
Peak: 13 in Apr 2023
across 5 sources since Mar 2023

Extended reach

1,797,837
potential audience

Total likes

20,929

Video views

1,756,902

Mentions per month

Mar 2023 – Dec 2025

Where it's discussed

  • X / Twitter51 posts
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  • Bluesky2 posts
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AI synopsis

What people are saying

Discussions highlight the scientific significance of the paper, with several references to its peer-reviewed nature and potential to transform food policies, using words like 'comprehensive,' 'crucial,' and 'game changer.' Many examples discuss reforming ultraprocessed foods to mitigate health risks, reflecting strong interest and recognition of the article's potential impact on health behaviors and policies.

AgreementModerate agreement

Most discussions support the importance of re-engineering ultraprocessed foods and acknowledge the significance of the research.

InterestHigh interest

Participants show high interest, frequently referencing the article and its implications for health and food reformulation.

EngagementHigh engagement

Comments include detailed mentions of the study, potential impacts, and calls for future coverage or action, indicating deep engagement.

ImpactModerate impact

While some recognize the potential influence on public health and food industry practices, overall impact perceptions seem moderate, emphasizing importance but acknowledging ongoing challenges.

Abstract in brief

  • Ultraprocessed foods are harmful because they disrupt metabolism, increase fat, impair mitochondrial function, cause insulin resistance, and contribute to health problems like obesity and liver and brain issues.
  • The authors partnered with the Kuwaiti Danish Dairy Company to scientifically evaluate all their products, analyzing ingredients, additives, and toxins to understand their health impacts.
  • They developed a Metabolic Matrix based on scientific principles to categorize products and guide reformulation efforts, aiming to improve health outcomes and encourage other food companies to adopt similar strategies.]

Top posts

Most liked on X and Bluesky
Frontiers - Nutrition
@FrontNutrition · X

New Research: The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the liver, and support the brain: Ultraprocessed food is established as a metabolic disruptor acting to increase adiposity, reduce mitochondrial… https://t.co/9TLSC0VGKV #Nutrition

Apr 17, 2023 · 2 likes · 2 shares · 3,919 followers View post →
Deep Dive with Dr. Greg
@gnigh · X

Thank goodness they are figuring out how to make ultra processed foods healthier. I wonder if a team of scientists could come up with a way to eat even healthier than by eating healthier ultra processed foods. https://t.co/12bxpBSRC7

Apr 11, 2023 · 2 likes · 666 followers View post →
Jeffrey A. Hirschfield, MD
@DrHirschfield · X

Surprise, surprise! @ACLifeMed @AmerAcadPeds @NutritionMadeS3 @plant_endo https://t.co/yeiBupLxMC

Apr 4, 2023 · 1 like · 11,938 followers View post →
Navigating water scarcity with satellite precision
@2C_ornot2C · X

@AukeHoekstra @MattsterT3 @jacopogio The impact on gut biome is esp. important given recent discoveries on brain-gut connection. Also acting to increase adiposity, reduce mitochondrial efficiency, drive insulin resistance, alter growth. https://t.co/WhsXXC9g1o Hyperpalatability only small part of damage done

Feb 16, 2024 · 1 like · 2,154 followers View post →
Robert Reames
@robertreames · X

The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the liver, and support the brain https://t.co/LuETlVoZYW #reviveandsustainwellness

May 23, 2024 · 1 like · 1,761 followers View post →
Keri Sprung
@KeriSprung · X

“Instead of “Can we make healthy food tasty? Can we make tasty food healthy?” Fascinating. https://t.co/bjGS6Tbhh1

Apr 8, 2023 · 1 like · 1,505 followers View post →

All mentions

Robert H. Lustig, MD, MSL
@robertlustigmd.bsky.social · Bluesky

Over 50K views on our article, "The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the liver, and support the brain". Take a look, if you haven't already: www.frontiersin.org/journals/nut...

Jun 30, 2025 · 1 like View post →
Robert H. Lustig, MD, MSL
@robertlustigmd.bsky.social · Bluesky

1. The Metabolic Matrix (pubmed.ncbi.nlm.nih.gov/37063330/), which says three things: protect the liver, feed the gut, support the brain. Any food that does all three is healthy, ultraprocessed or not. Any food that does none of the three is poison, ultraprocessed or not.

Jan 7, 2025 · 1 share View post →
Robert Reames
@robertreames · X

The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the liver, and support the brain https://t.co/LuETlVoZYW #reviveandsustainwellness

May 23, 2024 · 1 like · 1,761 followers View post →
Discernment
@_discernment · X

The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the liver, and support the brain https://t.co/72bQmO7KC2

May 11, 2024 · 4 followers View post →
MetabolicalMe
@MetabolicalMe · X

RT @Hypoglycemia101: Comprehensive peer-reviewed methods paper published in Frontiers of Nutrition: The Metabolic Matrix: Re-engineering u…

Apr 29, 2024 · 2 shares · 40 followers View post →
Kate Fisher
@KateFis53490509 · X

The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the liver, and support the brain ... https://t.co/w10I5dnZiy

Mar 21, 2024 · 5 followers View post →
Navigating water scarcity with satellite precision
@2C_ornot2C · X

@AukeHoekstra @MattsterT3 @jacopogio The impact on gut biome is esp. important given recent discoveries on brain-gut connection. Also acting to increase adiposity, reduce mitochondrial efficiency, drive insulin resistance, alter growth. https://t.co/WhsXXC9g1o Hyperpalatability only small part of damage done

Feb 16, 2024 · 1 like · 2,154 followers View post →
Dr. Maha Alenazy
@MahaDahmashi · X

@RobertLustigMD I searched for his paper following his advisory (which is unpaid as I learned) to the KDD along side a brilliant team and I found it

Feb 7, 2024 · 920 followers View post →
Valeria Tivnan
@ValeriaTivnan1 · X

Ultra-process foods hurt our health in many ways. This paper shows how complex it is to re-engineer them! The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the liver, and support the brain https://t.co/KWEjTapial

Feb 7, 2024 · 1 like · 325 followers View post →
Matts Nylander
@matts_nylander · X

Prof. MD Robert Lustig & colleagues were involved in a project converting a part of the Kuwait Danish Dairy Company list of food items to more healthy alternatives 2021-2022. A paper on the project is available. Frontiers in Nutrition 30 March 2023: https://t.co/O2eAbXjufB

Dec 22, 2023 · 11 followers View post →
MetabolicalMe
@MetabolicalMe · X

This peer-reviewed paper in Frontiers in Nutrition, "The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the liver, and support the brain" paper is receiving more views than 96% of all other papers on the platform. https://t.co/7YdcdnJsoN

Nov 24, 2023 · 1 like · 40 followers View post →
Rohith Shivanath
@RShiva299 · X

Frontiers | The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the liver, and support the brain https://t.co/OcOyhJOL9A

Nov 22, 2023 · 1 like · 63 followers View post →
j Kennedy
@jedwinkennedy · X

RT @emily_b_queen: "Ultraprocessed foods are only 'cheap' when the costs of their negative metabolic impact are externalized to health care…

Sep 13, 2023 · 22 shares · 5 followers View post →
HarryPangas
@haralambosPang1 · X

The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the liver, and support the brain https://t.co/kBtvg9rti0

Sep 10, 2023 · 423 followers View post →
ABertoG.eth
@ABertoG_eth · X

RT @emily_b_queen: "Ultraprocessed foods are only 'cheap' when the costs of their negative metabolic impact are externalized to health care…

Sep 9, 2023 · 22 shares · 13 followers View post →
nicolas salic
@nicolassalic · X

RT @emily_b_queen: "Ultraprocessed foods are only 'cheap' when the costs of their negative metabolic impact are externalized to health care…

Sep 5, 2023 · 22 shares · 11 followers View post →
Alan Flenley
@AlanFlenley · X

RT @emily_b_queen: "Ultraprocessed foods are only 'cheap' when the costs of their negative metabolic impact are externalized to health care…

Sep 1, 2023 · 22 shares · 11 followers View post →
haikts
@ha1kts · X

RT @emily_b_queen: "Ultraprocessed foods are only 'cheap' when the costs of their negative metabolic impact are externalized to health care…

Aug 25, 2023 · 22 shares · 33 followers View post →
Nickie
@Nickie06060705 · X

https://t.co/XEFIj1PMgq

Aug 16, 2023 · 3 followers View post →
m1977
@tips34 · X

RT @emily_b_queen: "Ultraprocessed foods are only 'cheap' when the costs of their negative metabolic impact are externalized to health care…

Aug 13, 2023 · 22 shares · 2 followers View post →
Marty
@CaroleMarty12 · X

RT @emily_b_queen: "Ultraprocessed foods are only 'cheap' when the costs of their negative metabolic impact are externalized to health care…

Aug 11, 2023 · 22 shares · 31 followers View post →
Marty
@CaroleMarty12 · X

RT @emily_b_queen: "Ultraprocessed foods are only 'cheap' when the costs of their negative metabolic impact are externalized to health care…

Aug 8, 2023 · 22 shares · 31 followers View post →
dev0x.eth
@dev0x_eth · X

RT @emily_b_queen: "Ultraprocessed foods are only 'cheap' when the costs of their negative metabolic impact are externalized to health care…

Aug 7, 2023 · 22 shares · 172 followers View post →
NICOLAS Manon
@manonzfm · X

RT @emily_b_queen: "Ultraprocessed foods are only 'cheap' when the costs of their negative metabolic impact are externalized to health care…

Aug 6, 2023 · 22 shares · 27 followers View post →
Faby Jeong
@fabiana93937915 · X

RT @emily_b_queen: "Ultraprocessed foods are only 'cheap' when the costs of their negative metabolic impact are externalized to health care…

Aug 5, 2023 · 22 shares · 62 followers View post →
simona sgavassi
@simona_sgavassi · X

RT @emily_b_queen: "Ultraprocessed foods are only 'cheap' when the costs of their negative metabolic impact are externalized to health care…

Aug 3, 2023 · 22 shares · 9 followers View post →
Neil Williams
@hafodneil · X

@ProfKarolSikora Needs addressing somehow. https://t.co/IR6x23PLgH

Jul 31, 2023 · 172 followers View post →
Juman Al-Saqlawi
@jalsaqlawi · X

RT @emily_b_queen: "Ultraprocessed foods are only 'cheap' when the costs of their negative metabolic impact are externalized to health care…

Jul 24, 2023 · 22 shares · 18 followers View post →
Jay
@jay8838 · X

RT @emily_b_queen: "Ultraprocessed foods are only 'cheap' when the costs of their negative metabolic impact are externalized to health care…

Jul 23, 2023 · 22 shares · 26 followers View post →
Derek Wastell
@WastellDerek · X

RT @emily_b_queen: "Ultraprocessed foods are only 'cheap' when the costs of their negative metabolic impact are externalized to health care…

Jul 23, 2023 · 22 shares · 10 followers View post →
Arbiter Anubis
@ArbiterAnubis · X

The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the liver, and support the brain via @RobertLustigMD https://t.co/bL8U55G5HF

Jul 19, 2023 · 4,176 followers View post →
gourmetmetrics
@gourmetmetrics · X

RT @gourmetmetrics: Nutrient Profiling meets the metabolic matrix. Food is more than the sum of its nutrient parts. Linked below is one mo…

Jul 17, 2023 · 1 share · 667 followers View post →
gourmetmetrics
@gourmetmetrics · X

Nutrient Profiling meets the metabolic matrix. Food is more than the sum of its nutrient parts. Linked below is one more attempt to capture the complexity using the tools of nutrient profiling. #healthy #eatright #foodmatrix #UPF #staycurious https://t.co/lyRuz2Zjv8

Jul 17, 2023 · 1 like · 1 share · 667 followers View post →
Bill Kinnan
@Kinnan5 · X

RT @emily_b_queen: "Ultraprocessed foods are only 'cheap' when the costs of their negative metabolic impact are externalized to health care…

Jul 13, 2023 · 22 shares · 15 followers View post →
James
@JamesJimkim1987 · X

RT @emily_b_queen: "Ultraprocessed foods are only 'cheap' when the costs of their negative metabolic impact are externalized to health care…

Jul 10, 2023 · 22 shares · 24 followers View post →
Brian
@DeFi_Brian · X

RT @emily_b_queen: "Ultraprocessed foods are only 'cheap' when the costs of their negative metabolic impact are externalized to health care…

Jul 10, 2023 · 22 shares · 1,506 followers View post →
Taafa.eth
@Taafa_eth · X

RT @emily_b_queen: "Ultraprocessed foods are only 'cheap' when the costs of their negative metabolic impact are externalized to health care…

Jul 6, 2023 · 22 shares · 291 followers View post →
Kenzie CRYPTOBURGER
@kenzieholdbtc · X

RT @emily_b_queen: "Ultraprocessed foods are only 'cheap' when the costs of their negative metabolic impact are externalized to health care…

Jul 6, 2023 · 22 shares · 526 followers View post →
Nutritious Minds
@drrachelvgow · X

It is not a question at all honestly! The statement should be ultraprocessed food is killing us. But great that it has made media attention! Please read our newly published article in Frontiers of Nutrition

Jun 5, 2023 · 1 like · 916 followers View post →
Livia Solustri
@Livia_Sole · X

@Join_ZOE I’d love if you could cover this concept of the metabolic matrix in your next podcast https://t.co/Q32xfTWOft

May 13, 2023 · 1 followers View post →
Hung Nguyen-Ngoc
@hungnguyenngok · X

RT @FrontNutrition: New Research: The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the liver, and support…

Apr 17, 2023 · 2 shares · 230 followers View post →
Frontiers - Nutrition
@FrontNutrition · X

New Research: The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the liver, and support the brain: Ultraprocessed food is established as a metabolic disruptor acting to increase adiposity, reduce mitochondrial… https://t.co/9TLSC0VGKV #Nutrition

Apr 17, 2023 · 2 likes · 2 shares · 3,919 followers View post →
Adipose Papers
@adipose_papers · X

The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the liver, and support the brain https://t.co/s7o5zBCoDI https://t.co/PRiWI2Lhzv

Apr 17, 2023 · 2,470 followers View post →
Nutritious Minds
@drrachelvgow · X

Please enjoy reading our newly published paper: The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the liver, and support the brain https://t.co/pQ4yvuf9wZ

Apr 15, 2023 · 916 followers View post →
Deep Dive with Dr. Greg
@gnigh · X

Thank goodness they are figuring out how to make ultra processed foods healthier. I wonder if a team of scientists could come up with a way to eat even healthier than by eating healthier ultra processed foods. https://t.co/12bxpBSRC7

Apr 11, 2023 · 2 likes · 666 followers View post →
Keri Sprung
@KeriSprung · X

“Instead of “Can we make healthy food tasty? Can we make tasty food healthy?” Fascinating. https://t.co/bjGS6Tbhh1

Apr 8, 2023 · 1 like · 1,505 followers View post →
Keri Sprung
@KeriSprung · X

The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the liver, and support the brain https://t.co/JrC3XtIhv0 #lustig

Apr 8, 2023 · 1,505 followers View post →
kelly (under development)
@kelly_mctest · X

RT @Hypoglycemia101: Comprehensive peer-reviewed methods paper published in Frontiers of Nutrition: The Metabolic Matrix: Re-engineering u…

Apr 8, 2023 · 2 shares · 178 followers View post →
Hypoglycemia Support Foundation
@Hypoglycemia101 · X

Comprehensive peer-reviewed methods paper published in Frontiers of Nutrition: The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the liver, and support the brain https://t.co/EtJ6LbhPZg

Apr 8, 2023 · 1 like · 2 shares · 408 followers View post →
Cynthia Copeland
@cyncopelandLIVE · X

While processed food may indeed be here to stay, some clever folks are working hard to help make it healthier. @RobertLustigMD https://t.co/fBvhnIB0cQ

Apr 4, 2023 · 1 like · 173 followers View post →
Jeffrey A. Hirschfield, MD
@DrHirschfield · X

Surprise, surprise! @ACLifeMed @AmerAcadPeds @NutritionMadeS3 @plant_endo https://t.co/yeiBupLxMC

Apr 4, 2023 · 1 like · 11,938 followers View post →
Barbara Frost
@Barbara01296416 · X

This! https://t.co/PopCiVX9Zd

Apr 1, 2023 · 362 followers View post →
Emily Queen
@emily_b_queen · X

"Ultraprocessed foods are only 'cheap' when the costs of their negative metabolic impact are externalized to health care and public health budgets." If processed foods aren't going anywhere... how can we re-engineer them? https://t.co/b96AC2mMas

Mar 30, 2023 · 1 like · 22 shares · 35 followers View post →
Robert H. Lustig Research Foundation
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org/journals/nutrition/articles/10.3389/fnut. 2023.1098453/full ...and we just presented them in Davos this past Wednesday: https://sdgtent.com/events ...

Dec 15, 2025 View →
Metabolical Me
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org/journals/nutrition/articles/10.3389/fnut. 2023.1098453/full ...and we just presented them in Davos this past Wednesday: https://sdgtent.com/events ...

Dec 15, 2025 View →
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https://www.frontiersin.org/articles/10.3389/fnut. 2023.1098453/full? The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the.

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Perfact | San Francisco CA
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org/articles/10.3389/fnut. 2023.1098453/full? The Metabolic Matrix: Re-engineering ultraprocessed foods to feed the gut, protect the. FRONTIERSIN.ORG. The ...

Dec 15, 2025 View →
"After reading countless studies, talking to dozens of experts and ...
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org/journals/nutrition/articles/10.3389/fnut. 2023.1098453/full ...and we just presented them in Davos this past Wednesday: https://sdgtent ...

Dec 14, 2025 View →
The War Over Ultraprocessed Foods Recently the city of San ...
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https://www.frontiersin.org/articles/10.3389/fnut. 2023.1098453/full · No photo description available. Lori Clay and 2 others. 3 reactions ·. 3 ...

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Characteristics of high-quality food
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Editorial observation: they never define what ultraprocessed food is ...
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Certain ultraprocessed foods, or UPFs, are contributing to worldwide ...
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Companies care more about shelf-life than your life. Excellent article ...
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Global corporations rake in $1.9 trillion selling ultra-processed foods ...
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NEW: ASPEN has signed on to the Healthcare Nutrition Council ...
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... Nut spreads Sweets and biscuits Frozen foods like pizza, chips and ... org/journals/nutrition/articles/10.3389/fnut. 2023.1098453/full ...

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Target "ultra-processed foods" to tackle the chronic disease ...
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https://www.frontiersin.org/articles/10.3389/fnut. 2023.1098453/full · No photo description available. Oscar Sanchez and 3 others. 4 reactions.

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Ultra-processed foods/fast foods disrupt lipid production and ECS ...
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https://www.frontiersin.org/articles/10.3389/fnut. 2023.1098453/full. No photo description available. Lori Clay and 2 others ·

Aug 13, 2025 View →
The major companies that produce and sell ultraprocessed foods ...
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org/journals/nutrition/articles/10.3389/fnut. 2023.1098453/full ...and we just presented them in Davos this past Wednesday: https://sdgtent ...

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Over 50K views on our article, "The Metabolic Matrix: Re ...
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The Novo Nordisk Foundation and University of Copenhagen ...
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Ultra-Processed People: Why Do We All Eat Stuff That Isn't Food ...
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Processed foods' impact on global diets and health
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What are the health consequences of consuming ultra-processed ...
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"Morgan & Morgan has filed a first-of-its-kind lawsuit against food ...
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... Nut and Krave cereals, and Nutri-Grain bars.The company can no ... https://www.frontiersin.org/articles/10.3389/fnut. 2023.1098453/full.

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It's a myth (that the food marketing companies are pushing) that's ...
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health concerns about ultra-processed korean foods
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Robert - Thanks for making this possible! Don't know what I'm talking ...
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#ultraprocessedfood Ultra Processed People - With the pandemic off ...
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https://www.frontiersin.org/articles/10.3389/fnut. 2023.1098453/full · No photo description available. Oscar Sanchez and 3 others. 4 reactions.

Jun 9, 2023 View →
Excess sugar consumption from an ultra-processed diet is the ...
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... 10.3389/fnut.2023.1098453/full Sign up for my FREE weekly newsletter to improve your health: https://bit.ly/TryThisNewsletter This episode ...

May 22, 2023 View →
#metabolicmatrix | Wolfram Alderson
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... 10.3389/fnut.2023.1098453/full · Like · Reply · 1 Reaction 2 Reactions. Adel Alturki, graphic · Adel Alturki. Researcher | Clinical Nutrition & ...

May 4, 2023 View →
Ultra Processed Foods and the Microbiome. There is a link between ...
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More coming on what this means and what they did. https://www.frontiersin.org/articles/10.3389/fnut. 2023.1098453/full. No photo description ...

Apr 25, 2023 View →
If you're wondering why nutrition recommendations are so confusing ...
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And Honey Nut Cheerios ranked higher than an egg fried in butter??? ... https://www.frontiersin.org/articles/10.3389/fnut. 2023.1098453/full.

May 29, 2022 View →
''The concern about these products is not just a matter of scientific ...
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https://www.frontiersin.org/articles/10.3389/fnut. 2023.1098453/full · No photo description available. Lori Clay and 2 others. 3 reactions ·. 3 ...

Feb 9, 2022 View →
Protect the Liver - we should scream it from the rooftops.
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https://www.frontiersin.org/articles/10.3389/fnut. 2023.1098453/full No subject is beyond the scope of conversation. We will discuss ...

Oct 25, 2021 View →
From my current OU module- SDT306: YOSEPH ARAYAIt's very ...
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https://www.frontiersin.org/articles/10.3389/fnut. 2023.1098453/full. No photo description available. Lori Clay and 2 others ·

Mar 22, 2020 View →
NÂNG CẤP TỪ VỰNG / NGỮ PHÁP/ CẤU TRÚC TỪ BAND 5.0 ...
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https://www.frontiersin.org/articles/10.3389/fnut. 2023.1098453/full · No photo description available. Lori Clay and 2 others. 3 reactions ·. 3 ...

Nov 9, 2018 View →
The war against diabetes may soon receive a boost with the launch ...
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https://www.frontiersin.org/articles/10.3389/fnut. 2023.1098453/full · No photo description available. Oscar Sanchez and 3 others ·

Jun 21, 2018 View →
Of interest, though obvious it is hopeful that more people will take ...
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https://www.frontiersin.org/articles/10.3389/fnut. 2023.1098453/full · No photo description available. Oscar Sanchez and 3 others. 4 reactions.

Sep 7, 2016 View →